Human Gene ACOT9 (ENST00000379303.10_9) from GENCODE V47lift37

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Description: acyl-CoA thioesterase 9, transcript variant 1 (from RefSeq NM_001037171.2)
Gencode Transcript: ENST00000379303.10_9
Gencode Gene: ENSG00000123130.17_14
Transcript (Including UTRs)
Position: hg19 chrX:23,719,172-23,761,393 Size: 42,222 Total Exon Count: 16 Strand: -
Coding Region
Position: hg19 chrX:23,722,011-23,761,261 Size: 39,251 Coding Exon Count: 16

Page Index	Sequence and Links	UniProtKB Comments	Primers	MalaCards	CTD
Gene Alleles	RNA-Seq Expression	Microarray Expression	RNA Structure	Protein Structure	Other Species
GO Annotations	mRNA Descriptions	Pathways	Other Names	Model Information	Methods

Data last updated at UCSC: 2024-08-22 23:36:26

Sequence and Links to Tools and Databases

Genomic Sequence (chrX:23,719,172-23,761,393)			mRNA (may differ from genome)		Protein (448 aa)
Gene Sorter	Genome Browser	Other Species FASTA	VisiGene	Gene interactions	Table Schema
AlphaFold	BioGPS	Ensembl	Entrez Gene	ExonPrimer	GeneCards
HGNC	Malacards	MGI	OMIM	PubMed	Reactome
UniProtKB	Wikipedia	BioGrid CRISPR DB

Comments and Description Text from UniProtKB


	ID: ACOT9_HUMAN DESCRIPTION: RecName: Full=Acyl-coenzyme A thioesterase 9, mitochondrial; Short=Acyl-CoA thioesterase 9; EC=3.1.2.-; AltName: Full=Acyl-CoA thioester hydrolase 9; Flags: Precursor; FUNCTION: Acyl-CoA thioesterases are a group of enzymes that catalyze the hydrolysis of acyl-CoAs to the free fatty acid and coenzyme A (CoASH), providing the potential to regulate intracellular levels of acyl-CoAs, free fatty acids and CoASH. Active on long chain acyl-CoAs. SUBUNIT: Interacts with NYAP1, NYAP2 and MYO16 (By similarity). SUBCELLULAR LOCATION: Mitochondrion (By similarity). SIMILARITY: Belongs to the acyl coenzyme A hydrolase family.

Primer design for this transcript

Primer3Plus can design qPCR Primers that straddle exon-exon-junctions, which amplify only cDNA, not genomic DNA.
Click here to load the transcript sequence and exon structure into Primer3Plus

Exonprimer can design one pair of Sanger sequencing primers around every exon, located in non-genic sequence.
Click here to open Exonprimer with this transcript

To design primers for a non-coding sequence, zoom to a region of interest and select from the drop-down menu: View > In External Tools > Primer3

MalaCards Disease Associations


	MalaCards Gene Search: ACOT9 Diseases sorted by gene-association score: kabuki syndrome 1 (2)

Comparative Toxicogenomics Database (CTD)


	The following chemicals interact with this gene D003993 Dibutyl Phthalate C111118 2',3,3',4',5-pentachloro-4-hydroxybiphenyl C014211 2,3,7,8-tetrachlorodibenzofuran D015073 2-Acetylaminofluorene C009505 4,4'-diaminodiphenylmethane D015123 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide D000082 Acetaminophen D001554 Benzene D002251 Carbon Tetrachloride D002509 Cephaloridine more ... click here to view the complete list

Common Gene Haplotype Alleles


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RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)


	Highest median expression: 12.86 RPKM in Lung Total median expression: 387.84 RPKM View in GTEx track of Genome Browser View at GTEx portal View GTEx Body Map

Microarray Expression Data


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mRNA Secondary Structure of 3' and 5' UTRs

Region	Fold Energy	Bases	Energy/Base	Display As
5' UTR	-51.70	132	-0.392	Picture	PostScript	Text
3' UTR	-1168.30	2839	-0.412	Picture	PostScript	Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

Protein Domain and Structure Information

InterPro Domains: Graphical view of domain structure
IPR006683 - Thioestr_supf

SCOP Domains:
54637 - Thioesterase/thiol ester dehydrase-isomerase

ModBase Predicted Comparative 3D Structure on Q9Y305


Front	Top	Side

The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

Orthologous Genes in Other Species

Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.

Mouse	Rat	Zebrafish	D. melanogaster	C. elegans	S. cerevisiae
No ortholog	No ortholog	No ortholog	No ortholog	No ortholog	No ortholog
Gene Details	Gene Details
Gene Sorter	Gene Sorter
	RGD	Ensembl

Gene Ontology (GO) Annotations with Structured Vocabulary


	Molecular Function: GO:0003986 acetyl-CoA hydrolase activity GO:0016787 hydrolase activity GO:0047617 acyl-CoA hydrolase activity GO:0052689 carboxylic ester hydrolase activity Biological Process: GO:0006637 acyl-CoA metabolic process Cellular Component: GO:0005739 mitochondrion GO:0005759 mitochondrial matrix

Descriptions from all associated GenBank mRNAs


	AF132950 - Homo sapiens CGI-16 protein mRNA, complete cds. BX648512 - Homo sapiens mRNA; cDNA DKFZp686K1372 (from clone DKFZp686K1372). AK000659 - Homo sapiens cDNA FLJ20652 fis, clone KAT01774, highly similar to AF132950 Homo sapiens CGI-16 protein mRNA. AF241787 - Homo sapiens CGI16-iso mRNA, complete cds. AK024337 - Homo sapiens cDNA FLJ14275 fis, clone PLACE1005052, highly similar to Acyl-coenzyme A thioesterase 9 (EC 3.1.2.-). BC136671 - Homo sapiens acyl-CoA thioesterase 9, mRNA (cDNA clone MGC:168284 IMAGE:9020661), complete cds. BC144360 - Homo sapiens acyl-CoA thioesterase 9, mRNA (cDNA clone MGC:177898 IMAGE:9052881), complete cds. BC144370 - Homo sapiens cDNA clone IMAGE:9052891. AB528567 - Synthetic construct DNA, clone: pF1KB5521, Homo sapiens ACOT9 gene for acyl-CoA thioesterase 9, without stop codon, in Flexi system. JD366835 - Sequence 347859 from Patent EP1572962. JD518790 - Sequence 499814 from Patent EP1572962. JD189795 - Sequence 170819 from Patent EP1572962. JD269654 - Sequence 250678 from Patent EP1572962. JD354047 - Sequence 335071 from Patent EP1572962. JD378008 - Sequence 359032 from Patent EP1572962. JD249562 - Sequence 230586 from Patent EP1572962. JD458080 - Sequence 439104 from Patent EP1572962. JD226890 - Sequence 207914 from Patent EP1572962. JD079796 - Sequence 60820 from Patent EP1572962. JD181601 - Sequence 162625 from Patent EP1572962. JD180626 - Sequence 161650 from Patent EP1572962. JD472600 - Sequence 453624 from Patent EP1572962. JD185887 - Sequence 166911 from Patent EP1572962. JD136279 - Sequence 117303 from Patent EP1572962. JD534644 - Sequence 515668 from Patent EP1572962. JD243509 - Sequence 224533 from Patent EP1572962. JD441900 - Sequence 422924 from Patent EP1572962. JD532117 - Sequence 513141 from Patent EP1572962. JD088198 - Sequence 69222 from Patent EP1572962. JD377502 - Sequence 358526 from Patent EP1572962. JD454926 - Sequence 435950 from Patent EP1572962. JD475702 - Sequence 456726 from Patent EP1572962. JD365086 - Sequence 346110 from Patent EP1572962. JD053999 - Sequence 35023 from Patent EP1572962. JD517844 - Sequence 498868 from Patent EP1572962. JD366633 - Sequence 347657 from Patent EP1572962. JD366634 - Sequence 347658 from Patent EP1572962. JD144599 - Sequence 125623 from Patent EP1572962. JD425806 - Sequence 406830 from Patent EP1572962. JD112119 - Sequence 93143 from Patent EP1572962. JD112118 - Sequence 93142 from Patent EP1572962. JD179346 - Sequence 160370 from Patent EP1572962. JD433932 - Sequence 414956 from Patent EP1572962. JD098761 - Sequence 79785 from Patent EP1572962. JD417522 - Sequence 398546 from Patent EP1572962. BC012573 - Homo sapiens acyl-CoA thioesterase 9, mRNA (cDNA clone IMAGE:3827798), complete cds. JF432454 - Synthetic construct Homo sapiens clone IMAGE:100073665 acyl-CoA thioesterase 9 (ACOT9) gene, encodes complete protein. KJ904697 - Synthetic construct Homo sapiens clone ccsbBroadEn_14091 ACOT9 gene, encodes complete protein. JD173879 - Sequence 154903 from Patent EP1572962.

Biochemical and Signaling Pathways


	BioCyc Knowledge Library PWY-5148 - acyl-CoA hydrolysis PWY-5972 - stearate biosynthesis PWY-5994 - palmitate biosynthesis (cytoplasm) PWY-5996 - oleate biosynthesis PWY-8042 - acylceramide biosynthesis Reactome (by CSHL, EBI, and GO) Protein Q9Y305 (Reactome details) participates in the following event(s): R-HSA-5690066 ACOT2,9,THEM4,5 hydrolyse MCFA-CoA, LCFA-CoA R-HSA-77289 Mitochondrial Fatty Acid Beta-Oxidation R-HSA-8978868 Fatty acid metabolism R-HSA-556833 Metabolism of lipids R-HSA-1430728 Metabolism

Other Names for This Gene


	Alternate Gene Symbols: ACOT9_HUMAN, B3KNC9, B7ZM94, CGI-16, ENST00000379303.1, ENST00000379303.2, ENST00000379303.3, ENST00000379303.4, ENST00000379303.5, ENST00000379303.6, ENST00000379303.7, ENST00000379303.8, ENST00000379303.9, NM_001037171, Q9Y305, uc318owt.1, uc318owt.2 UCSC ID: ENST00000379303.10_9 RefSeq Accession: NM_001037171.2 Protein: Q9Y305 (aka ACOT9_HUMAN)

Gene Model Information


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Methods, Credits, and Use Restrictions


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