Human Gene ADAP1 (ENST00000265846.10_8) from GENCODE V47lift37 |
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 Sequence and Links to Tools and Databases
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Comments and Description Text from UniProtKB
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ID: ADAP1_HUMAN
DESCRIPTION: RecName: Full=Arf-GAP with dual PH domain-containing protein 1; AltName: Full=Centaurin-alpha-1; Short=Cnt-a1; AltName: Full=Putative MAPK-activating protein PM25;
FUNCTION: GTPase-activating protein for the ADP ribosylation factor family (Probable). Binds phosphatidylinositol 3,4,5- trisphosphate (PtdInsP3) and inositol 1,3,4,5-tetrakisphosphate (InsP4).
SUBUNIT: Interacts with PRKCA, PRKCI and PRKCZ. Interacts with the N-terminal region of PRKD1.
SUBCELLULAR LOCATION: Nucleus. Cytoplasm. Note=Recruited to the plasma membrane upon epidermal growth factor-dependent activation of phosphatidylinositol 4,5-diphosphate (PtdInsP2) 3-kinase.
TISSUE SPECIFICITY: Expressed at highest levels in brain and at lower levels in peripheral blood leukocytes.
PTM: Phosphorylated by PRKCA, PRKCI, PRKCZ and PRKD1 in vitro.
SIMILARITY: Contains 1 Arf-GAP domain.
SIMILARITY: Contains 2 PH domains.
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Primer design for this transcript
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Comparative Toxicogenomics Database (CTD)
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The following chemicals interact with this gene
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 Common Gene Haplotype Alleles
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RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
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Microarray Expression Data
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Press "+" in the title bar above to open this section.
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mRNA Secondary Structure of 3' and 5' UTRs
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The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
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Protein Domain and Structure Information
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InterPro Domains: Graphical view of domain structure
IPR001164 - ArfGAP
IPR011993 - PH_like_dom
IPR001849 - Pleckstrin_homology
Pfam Domains:
PF00169 - PH domain
PF01412 - Putative GTPase activating protein for Arf
SCOP Domains:
50729 - PH domain-like
56281 - Metallo-hydrolase/oxidoreductase
57863 - ArfGap/RecO-like zinc finger
Protein Data Bank (PDB) 3-D Structure
ModBase Predicted Comparative 3D Structure on O75689
The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.
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Orthologous Genes in Other Species
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Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
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Gene Ontology (GO) Annotations with Structured Vocabulary
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Descriptions from all associated GenBank mRNAs
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BC033747 - Homo sapiens ArfGAP with dual PH domains 1, mRNA (cDNA clone MGC:45165 IMAGE:5195416), complete cds.
AB097049 - Homo sapiens mRNA for putative MAPK activating protein, complete cds, clone: PM25.
AF082324 - Homo sapiens phosphatidylinositol(3,4,5)trisphosphate binding protein p42IP4 mRNA, complete cds.
AK092471 - Homo sapiens cDNA FLJ35152 fis, clone PLACE6010732, highly similar to Centaurin-alpha 1.
AK124979 - Homo sapiens cDNA FLJ42989 fis, clone BRTHA2009803, highly similar to Centaurin-alpha 1.
JD255396 - Sequence 236420 from Patent EP1572962.
JD127953 - Sequence 108977 from Patent EP1572962.
JD418383 - Sequence 399407 from Patent EP1572962.
JD192493 - Sequence 173517 from Patent EP1572962.
JD559085 - Sequence 540109 from Patent EP1572962.
JD299789 - Sequence 280813 from Patent EP1572962.
JD402085 - Sequence 383109 from Patent EP1572962.
JD422468 - Sequence 403492 from Patent EP1572962.
JD390893 - Sequence 371917 from Patent EP1572962.
JD125336 - Sequence 106360 from Patent EP1572962.
JD191227 - Sequence 172251 from Patent EP1572962.
AK300644 - Homo sapiens cDNA FLJ54163 complete cds, highly similar to Centaurin-alpha 1.
JD394456 - Sequence 375480 from Patent EP1572962.
AK300859 - Homo sapiens cDNA FLJ54168 complete cds, highly similar to Centaurin-alpha 1.
JD335743 - Sequence 316767 from Patent EP1572962.
JD122302 - Sequence 103326 from Patent EP1572962.
JD403789 - Sequence 384813 from Patent EP1572962.
JD127260 - Sequence 108284 from Patent EP1572962.
AJ006422 - Homo sapiens mRNA for centaurin-alpha.
AK300999 - Homo sapiens cDNA FLJ59765 complete cds, highly similar to Centaurin-alpha 1.
JD074916 - Sequence 55940 from Patent EP1572962.
JD412455 - Sequence 393479 from Patent EP1572962.
JD207240 - Sequence 188264 from Patent EP1572962.
JD444725 - Sequence 425749 from Patent EP1572962.
AK290517 - Homo sapiens cDNA FLJ77789 complete cds.
JD210171 - Sequence 191195 from Patent EP1572962.
JD421613 - Sequence 402637 from Patent EP1572962.
JD560032 - Sequence 541056 from Patent EP1572962.
JD318786 - Sequence 299810 from Patent EP1572962.
KJ898337 - Synthetic construct Homo sapiens clone ccsbBroadEn_07731 ADAP1 gene, encodes complete protein.
AB587419 - Synthetic construct DNA, clone: pF1KB6565, Homo sapiens ADAP1 gene for ArfGAP with dual PH domains 1, without stop codon, in Flexi system.
JD140449 - Sequence 121473 from Patent EP1572962.
JD478325 - Sequence 459349 from Patent EP1572962.
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Other Names for This Gene
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Alternate Gene Symbols: A4D2Q2, ADAP1_HUMAN, B3KRZ4, B4DVA6, CENTA1, ENST00000265846.1, ENST00000265846.2, ENST00000265846.3, ENST00000265846.4, ENST00000265846.5, ENST00000265846.6, ENST00000265846.7, ENST00000265846.8, ENST00000265846.9, F6XZ68, H7C2Q4, NM_006869, O75689, uc317iep.1, uc317iep.2
UCSC ID: ENST00000265846.10_8
RefSeq Accession: NM_006869.4
Protein: O75689
(aka ADAP1_HUMAN)
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Gene Model Information
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for a detailed description of the fields of the table above.
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Methods, Credits, and Use Restrictions
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for details on how this gene model was made and data restrictions if any.
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US Server
