ID:PACR_HUMAN DESCRIPTION: RecName: Full=Pituitary adenylate cyclase-activating polypeptide type I receptor; Short=PACAP type I receptor; Short=PACAP-R-1; Short=PACAP-R1; Flags: Precursor; FUNCTION: This is a receptor for PACAP-27 and PACAP-38. The activity of this receptor is mediated by G proteins which activate adenylyl cyclase. May regulate the release of adrenocorticotropin, luteinizing hormone, growth hormone, prolactin, epinephrine, and catecholamine. May play a role in spermatogenesis and sperm motility. Causes smooth muscle relaxation and secretion in the gastrointestinal tract. SUBUNIT: Interacts (via N-terminal extracellular domain) with ADCYAP1. SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein. TISSUE SPECIFICITY: Most abundant in the brain, low expression in the lung, liver, thymus, spleen, pancreas and placenta. SIMILARITY: Belongs to the G-protein coupled receptor 2 family. SEQUENCE CAUTION: Sequence=BAA04466.1; Type=Erroneous initiation;
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
ModBase Predicted Comparative 3D Structure on P41586
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
Biological Process: GO:0007165 signal transduction GO:0007166 cell surface receptor signaling pathway GO:0007186 G-protein coupled receptor signaling pathway GO:0007202 activation of phospholipase C activity GO:0007275 multicellular organism development GO:0007283 spermatogenesis GO:0010524 positive regulation of calcium ion transport into cytosol GO:0019933 cAMP-mediated signaling GO:0030154 cell differentiation GO:0032355 response to estradiol GO:0033555 multicellular organismal response to stress GO:0042493 response to drug GO:0043950 positive regulation of cAMP-mediated signaling GO:0045471 response to ethanol GO:0046545 development of primary female sexual characteristics GO:0051057 positive regulation of small GTPase mediated signal transduction GO:0060548 negative regulation of cell death GO:0060732 positive regulation of inositol phosphate biosynthetic process
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Sequence and Links to Tools and Databases 
Common Gene Haplotype Alleles 
