Human Gene ADRA1B (ENST00000306675.5_6) from GENCODE V47lift37
  Description: adrenoceptor alpha 1B (from RefSeq NM_000679.4)
Gencode Transcript: ENST00000306675.5_6
Gencode Gene: ENSG00000170214.5_10
Transcript (Including UTRs)
   Position: hg19 chr5:159,343,489-159,400,019 Size: 56,531 Total Exon Count: 2 Strand: +
Coding Region
   Position: hg19 chr5:159,343,913-159,399,499 Size: 55,587 Coding Exon Count: 2 

Page IndexSequence and LinksUniProtKB CommentsPrimersCTDGene Alleles
RNA-Seq ExpressionMicroarray ExpressionRNA StructureProtein StructureOther SpeciesGO Annotations
mRNA DescriptionsPathwaysOther NamesModel InformationMethods
Data last updated at UCSC: 2024-08-22 23:36:26

-  Sequence and Links to Tools and Databases
 
Genomic Sequence (chr5:159,343,489-159,400,019)mRNA (may differ from genome)Protein (520 aa)
Gene SorterGenome BrowserOther Species FASTAVisiGeneGene interactionsTable Schema
AlphaFoldBioGPSEnsemblEntrez GeneExonPrimerGeneCards
HGNCMGIOMIMPubMedReactomeUniProtKB
WikipediaBioGrid CRISPR DB

-  Comments and Description Text from UniProtKB
  ID: ADA1B_HUMAN
DESCRIPTION: RecName: Full=Alpha-1B adrenergic receptor; AltName: Full=Alpha-1B adrenoreceptor; Short=Alpha-1B adrenoceptor;
FUNCTION: This alpha-adrenergic receptor mediates its action by association with G proteins that activate a phosphatidylinositol- calcium second messenger system. Its effect is mediated by G(q) and G(11) proteins. Nuclear ADRA1A-ADRA1B heterooligomers regulate phenylephrine (PE)-stimulated ERK signaling in cardiac myocytes.
SUBUNIT: Homo- and heterooligomer. Heterooligomerizes with ADRA1B homooligomers in cardiac myocytes.
SUBCELLULAR LOCATION: Nucleus membrane; Multi-pass membrane protein. Cell membrane; Multi-pass membrane protein. Note=Location at the nuclear membrane facilitates heterooligomerization and regulates ERK-mediated signaling in cardiac myocytes. signaling in cardiac myocytes. Colocalizes with GNAQ, PLCB1 as well as LAP2 at the nuclear membrane of cardiac myocytes.
SIMILARITY: Belongs to the G-protein coupled receptor 1 family. Adrenergic receptor subfamily. ADRA1B sub-subfamily.

-  Primer design for this transcript
 

Primer3Plus can design qPCR Primers that straddle exon-exon-junctions, which amplify only cDNA, not genomic DNA.
Click here to load the transcript sequence and exon structure into Primer3Plus

Exonprimer can design one pair of Sanger sequencing primers around every exon, located in non-genic sequence.
Click here to open Exonprimer with this transcript

To design primers for a non-coding sequence, zoom to a region of interest and select from the drop-down menu: View > In External Tools > Primer3


-  Comparative Toxicogenomics Database (CTD)
  The following chemicals interact with this gene           more ... click here to view the complete list

+  Common Gene Haplotype Alleles
  Press "+" in the title bar above to open this section.

-  RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
  Highest median expression: 13.31 RPKM in Artery - Aorta
Total median expression: 93.86 RPKM



View in GTEx track of Genome Browser    View at GTEx portal     View GTEx Body Map

+  Microarray Expression Data
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-  mRNA Secondary Structure of 3' and 5' UTRs
 
RegionFold EnergyBasesEnergy/Base
Display As
5' UTR -190.90424-0.450 Picture PostScript Text
3' UTR -231.60520-0.445 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Protein Domain and Structure Information
  InterPro Domains: Graphical view of domain structure
IPR000276 - 7TM_GPCR_Rhodpsn
IPR001115 - Adrene_rcpt_A1B
IPR002233 - Adrnrgc_rcpt
IPR017452 - GPCR_Rhodpsn_supfam

Pfam Domains:
PF00001 - 7 transmembrane receptor (rhodopsin family)
PF10320 - Serpentine type 7TM GPCR chemoreceptor Srsx

SCOP Domains:
81321 - Family A G protein-coupled receptor-like

ModBase Predicted Comparative 3D Structure on P35368
FrontTopSide
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-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
MouseRatZebrafishD. melanogasterC. elegansS. cerevisiae
No orthologNo orthologNo orthologNo orthologNo orthologNo ortholog
Gene DetailsGene Details    
Gene SorterGene Sorter    
 RGDEnsembl   
      
      

-  Gene Ontology (GO) Annotations with Structured Vocabulary
  Molecular Function:
GO:0004871 signal transducer activity
GO:0004930 G-protein coupled receptor activity
GO:0004935 adrenergic receptor activity
GO:0004937 alpha1-adrenergic receptor activity
GO:0005515 protein binding
GO:0046982 protein heterodimerization activity

Biological Process:
GO:0001994 norepinephrine-epinephrine vasoconstriction involved in regulation of systemic arterial blood pressure
GO:0006937 regulation of muscle contraction
GO:0007165 signal transduction
GO:0007186 G-protein coupled receptor signaling pathway
GO:0007188 adenylate cyclase-modulating G-protein coupled receptor signaling pathway
GO:0007200 phospholipase C-activating G-protein coupled receptor signaling pathway
GO:0007204 positive regulation of cytosolic calcium ion concentration
GO:0007267 cell-cell signaling
GO:0007275 multicellular organism development
GO:0008283 cell proliferation
GO:0019229 regulation of vasoconstriction
GO:0035556 intracellular signal transduction
GO:0042593 glucose homeostasis
GO:0043410 positive regulation of MAPK cascade
GO:0045907 positive regulation of vasoconstriction
GO:0045987 positive regulation of smooth muscle contraction
GO:0055117 regulation of cardiac muscle contraction
GO:0071880 adenylate cyclase-activating adrenergic receptor signaling pathway

Cellular Component:
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0005886 plasma membrane
GO:0005887 integral component of plasma membrane
GO:0005901 caveola
GO:0016020 membrane
GO:0016021 integral component of membrane
GO:0031965 nuclear membrane


-  Descriptions from all associated GenBank mRNAs
  U03865 - Human adrenergic alpha-1b receptor protein mRNA, complete cds.
BC136568 - Homo sapiens adrenergic, alpha-1B-, receptor, mRNA (cDNA clone MGC:168181 IMAGE:9020558), complete cds.
BC136569 - Homo sapiens adrenergic, alpha-1B-, receptor, mRNA (cDNA clone MGC:168182 IMAGE:9020559), complete cds.
L31773 - Human alpha-1B-adrenergic receptor mRNA, complete cds.
AK309989 - Homo sapiens cDNA, FLJ17031.
JD523176 - Sequence 504200 from Patent EP1572962.

-  Biochemical and Signaling Pathways
  BioCarta from NCI Cancer Genome Anatomy Project
h_plcdPathway - Phospholipase C d1 in phospholipid associated cell signaling

Reactome (by CSHL, EBI, and GO)

Protein P35368 (Reactome details) participates in the following event(s):

R-HSA-390641 Alpha-1 adrenoceptors bind catecholamines
R-HSA-749452 The Ligand:GPCR:Gq complex dissociates
R-HSA-751019 The Ligand:GPCR:G12/13 complex dissociates
R-HSA-749448 Liganded Gq-activating GPCRs bind inactive heterotrimeric Gq
R-HSA-751027 Liganded G12/13-activating GPCRs bind inactive heterotrimeric G-protein G12/13
R-HSA-379048 Liganded Gq/11-activating GPCRs act as GEFs for Gq/11
R-HSA-751029 Liganded G12/13-activating GPCR acts as a GEF for G12/13
R-HSA-390696 Adrenoceptors
R-HSA-416476 G alpha (q) signalling events
R-HSA-416482 G alpha (12/13) signalling events
R-HSA-375280 Amine ligand-binding receptors
R-HSA-388396 GPCR downstream signalling
R-HSA-373076 Class A/1 (Rhodopsin-like receptors)
R-HSA-372790 Signaling by GPCR
R-HSA-500792 GPCR ligand binding
R-HSA-162582 Signal Transduction

-  Other Names for This Gene
  Alternate Gene Symbols: ADA1B_HUMAN, B0LPE1, ENST00000306675.1, ENST00000306675.2, ENST00000306675.3, ENST00000306675.4, NM_000679, P35368, uc317nxb.1, uc317nxb.2
UCSC ID: ENST00000306675.5_6
RefSeq Accession: NM_000679.4
Protein: P35368 (aka ADA1B_HUMAN or A1AB_HUMAN)

-  Gene Model Information
  Click here for a detailed description of the fields of the table above.

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.