ID:AHR_HUMAN DESCRIPTION: RecName: Full=Aryl hydrocarbon receptor; Short=Ah receptor; Short=AhR; AltName: Full=Class E basic helix-loop-helix protein 76; Short=bHLHe76; Flags: Precursor; FUNCTION: Ligand-activated transcriptional activator. Binds to the XRE promoter region of genes it activates. Activates the expression of multiple phase I and II xenobiotic chemical metabolizing enzyme genes (such as the CYP1A1 gene). Mediates biochemical and toxic effects of halogenated aromatic hydrocarbons. Involved in cell-cycle regulation. Likely to play an important role in the development and maturation of many tissues. SUBUNIT: Binds MYBBP1A (By similarity). Efficient DNA binding requires dimerization with another bHLH protein. In the nucleus, heterodimer of AHR and ARNT. Interacts with coactivators including SRC-1, RIP140 and NOCA7, and with the corepressor SMRT. Interacts with NEDD8 and IVNS1ABP. INTERACTION: P27540:ARNT; NbExp=5; IntAct=EBI-80780, EBI-80809; P12977:EBNA3 (xeno); NbExp=5; IntAct=EBI-80780, EBI-993115; Q8NI08:NCOA7; NbExp=2; IntAct=EBI-80780, EBI-80799; Q9Y618:NCOR2; NbExp=2; IntAct=EBI-80780, EBI-80830; SUBCELLULAR LOCATION: Cytoplasm. Nucleus. Note=Initially cytoplasmic; upon binding with ligand and interaction with a HSP90, it translocates to the nucleus. TISSUE SPECIFICITY: Expressed in all tissues tested including blood, brain, heart, kidney, liver, lung, pancreas and skeletal muscle. INDUCTION: Induced or repressed by TGFB1 and dioxin in a cell-type specific fashion. Repressed by cAMP, retinoic acid, and 12-O- tetradecanoyl phorbol-13 acetate (TPA). SIMILARITY: Contains 1 bHLH (basic helix-loop-helix) domain. SIMILARITY: Contains 1 PAC (PAS-associated C-terminal) domain. SIMILARITY: Contains 2 PAS (PER-ARNT-SIM) domains.
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
ModBase Predicted Comparative 3D Structure on P35869
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
Gene Ontology (GO) Annotations with Structured Vocabulary
Molecular Function: GO:0000981 RNA polymerase II transcription factor activity, sequence-specific DNA binding GO:0001094 TFIID-class transcription factor binding GO:0001223 transcription coactivator binding GO:0003677 DNA binding GO:0003700 transcription factor activity, sequence-specific DNA binding GO:0004874 aryl hydrocarbon receptor activity GO:0004879 RNA polymerase II transcription factor activity, ligand-activated sequence-specific DNA binding GO:0005515 protein binding GO:0008134 transcription factor binding GO:0017025 TBP-class protein binding GO:0035326 enhancer binding GO:0044212 transcription regulatory region DNA binding GO:0046982 protein heterodimerization activity GO:0046983 protein dimerization activity GO:0051879 Hsp90 protein binding GO:0070888 E-box binding
Biological Process: GO:0001568 blood vessel development GO:0006351 transcription, DNA-templated GO:0006355 regulation of transcription, DNA-templated GO:0006357 regulation of transcription from RNA polymerase II promoter GO:0006366 transcription from RNA polymerase II promoter GO:0006805 xenobiotic metabolic process GO:0006915 apoptotic process GO:0007049 cell cycle GO:0009410 response to xenobiotic stimulus GO:0009636 response to toxic substance GO:0010468 regulation of gene expression GO:0019933 cAMP-mediated signaling GO:0030522 intracellular receptor signaling pathway GO:0030888 regulation of B cell proliferation GO:0032922 circadian regulation of gene expression GO:0045892 negative regulation of transcription, DNA-templated GO:0045893 positive regulation of transcription, DNA-templated GO:0045944 positive regulation of transcription from RNA polymerase II promoter GO:0048511 rhythmic process GO:0071320 cellular response to cAMP GO:1904322 cellular response to forskolin GO:1904613 cellular response to 2,3,7,8-tetrachlorodibenzodioxine
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Sequence and Links to Tools and Databases 
Common Gene Haplotype Alleles 
