Human Gene AHR (ENST00000242057.9_7) from GENCODE V47lift37
  Description: aryl hydrocarbon receptor (from RefSeq NM_001621.5)
Gencode Transcript: ENST00000242057.9_7
Gencode Gene: ENSG00000106546.14_13
Transcript (Including UTRs)
   Position: hg19 chr7:17,338,276-17,385,771 Size: 47,496 Total Exon Count: 11 Strand: +
Coding Region
   Position: hg19 chr7:17,338,889-17,382,688 Size: 43,800 Coding Exon Count: 11 

Page IndexSequence and LinksUniProtKB CommentsPrimersMalaCardsCTD
Gene AllelesRNA-Seq ExpressionMicroarray ExpressionRNA StructureProtein StructureOther Species
GO AnnotationsmRNA DescriptionsPathwaysOther NamesModel InformationMethods
Data last updated at UCSC: 2024-08-22 23:36:26

-  Sequence and Links to Tools and Databases
 
Genomic Sequence (chr7:17,338,276-17,385,771)mRNA (may differ from genome)Protein (848 aa)
Gene SorterGenome BrowserOther Species FASTAVisiGeneGene interactionsTable Schema
AlphaFoldBioGPSEnsemblEntrez GeneExonPrimerGeneCards
HGNCMalacardsMGIOMIMPubMedReactome
UniProtKBWikipediaBioGrid CRISPR DB

-  Comments and Description Text from UniProtKB
  ID: AHR_HUMAN
DESCRIPTION: RecName: Full=Aryl hydrocarbon receptor; Short=Ah receptor; Short=AhR; AltName: Full=Class E basic helix-loop-helix protein 76; Short=bHLHe76; Flags: Precursor;
FUNCTION: Ligand-activated transcriptional activator. Binds to the XRE promoter region of genes it activates. Activates the expression of multiple phase I and II xenobiotic chemical metabolizing enzyme genes (such as the CYP1A1 gene). Mediates biochemical and toxic effects of halogenated aromatic hydrocarbons. Involved in cell-cycle regulation. Likely to play an important role in the development and maturation of many tissues.
SUBUNIT: Binds MYBBP1A (By similarity). Efficient DNA binding requires dimerization with another bHLH protein. In the nucleus, heterodimer of AHR and ARNT. Interacts with coactivators including SRC-1, RIP140 and NOCA7, and with the corepressor SMRT. Interacts with NEDD8 and IVNS1ABP.
INTERACTION: P27540:ARNT; NbExp=5; IntAct=EBI-80780, EBI-80809; P12977:EBNA3 (xeno); NbExp=5; IntAct=EBI-80780, EBI-993115; Q8NI08:NCOA7; NbExp=2; IntAct=EBI-80780, EBI-80799; Q9Y618:NCOR2; NbExp=2; IntAct=EBI-80780, EBI-80830;
SUBCELLULAR LOCATION: Cytoplasm. Nucleus. Note=Initially cytoplasmic; upon binding with ligand and interaction with a HSP90, it translocates to the nucleus.
TISSUE SPECIFICITY: Expressed in all tissues tested including blood, brain, heart, kidney, liver, lung, pancreas and skeletal muscle.
INDUCTION: Induced or repressed by TGFB1 and dioxin in a cell-type specific fashion. Repressed by cAMP, retinoic acid, and 12-O- tetradecanoyl phorbol-13 acetate (TPA).
SIMILARITY: Contains 1 bHLH (basic helix-loop-helix) domain.
SIMILARITY: Contains 1 PAC (PAS-associated C-terminal) domain.
SIMILARITY: Contains 2 PAS (PER-ARNT-SIM) domains.

-  Primer design for this transcript
 

Primer3Plus can design qPCR Primers that straddle exon-exon-junctions, which amplify only cDNA, not genomic DNA.
Click here to load the transcript sequence and exon structure into Primer3Plus

Exonprimer can design one pair of Sanger sequencing primers around every exon, located in non-genic sequence.
Click here to open Exonprimer with this transcript

To design primers for a non-coding sequence, zoom to a region of interest and select from the drop-down menu: View > In External Tools > Primer3


-  MalaCards Disease Associations
  MalaCards Gene Search: AHR
Diseases sorted by gene-association score: eosinophilic fasciitis (18), seborrheic dermatitis (10), toxic oil syndrome (8), peanut allergy (6), penis agenesis (5), breast cancer (3)

-  Comparative Toxicogenomics Database (CTD)
  The following chemicals interact with this gene

+  Common Gene Haplotype Alleles
  Press "+" in the title bar above to open this section.

-  RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
  Highest median expression: 40.66 RPKM in Nerve - Tibial
Total median expression: 382.40 RPKM



View in GTEx track of Genome Browser    View at GTEx portal     View GTEx Body Map

+  Microarray Expression Data
  Press "+" in the title bar above to open this section.

-  mRNA Secondary Structure of 3' and 5' UTRs
 
RegionFold EnergyBasesEnergy/Base
Display As
5' UTR -337.20613-0.550 Picture PostScript Text
3' UTR -914.203083-0.297 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Protein Domain and Structure Information
  InterPro Domains: Graphical view of domain structure
IPR011598 - HLH_dom
IPR001610 - PAC
IPR000014 - PAS
IPR013767 - PAS_fold
IPR013655 - PAS_fold_3

Pfam Domains:
PF00010 - Helix-loop-helix DNA-binding domain
PF00989 - PAS fold
PF08447 - PAS fold
PF13426 - PAS domain
PF14598 - PAS domain

SCOP Domains:
47459 - HLH, helix-loop-helix DNA-binding domain
55785 - PYP-like sensor domain (PAS domain)
54427 - NTF2-like

ModBase Predicted Comparative 3D Structure on P35869
FrontTopSide
The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
MouseRatZebrafishD. melanogasterC. elegansS. cerevisiae
No orthologNo orthologNo orthologNo orthologNo orthologNo ortholog
Gene DetailsGene Details    
Gene SorterGene Sorter    
 RGD    
      
      

-  Gene Ontology (GO) Annotations with Structured Vocabulary
  Molecular Function:
GO:0000981 RNA polymerase II transcription factor activity, sequence-specific DNA binding
GO:0001094 TFIID-class transcription factor binding
GO:0001223 transcription coactivator binding
GO:0003677 DNA binding
GO:0003700 transcription factor activity, sequence-specific DNA binding
GO:0004874 aryl hydrocarbon receptor activity
GO:0004879 RNA polymerase II transcription factor activity, ligand-activated sequence-specific DNA binding
GO:0005515 protein binding
GO:0008134 transcription factor binding
GO:0017025 TBP-class protein binding
GO:0035326 enhancer binding
GO:0044212 transcription regulatory region DNA binding
GO:0046982 protein heterodimerization activity
GO:0046983 protein dimerization activity
GO:0051879 Hsp90 protein binding
GO:0070888 E-box binding

Biological Process:
GO:0001568 blood vessel development
GO:0006351 transcription, DNA-templated
GO:0006355 regulation of transcription, DNA-templated
GO:0006357 regulation of transcription from RNA polymerase II promoter
GO:0006366 transcription from RNA polymerase II promoter
GO:0006805 xenobiotic metabolic process
GO:0006915 apoptotic process
GO:0007049 cell cycle
GO:0009410 response to xenobiotic stimulus
GO:0009636 response to toxic substance
GO:0010468 regulation of gene expression
GO:0019933 cAMP-mediated signaling
GO:0030522 intracellular receptor signaling pathway
GO:0030888 regulation of B cell proliferation
GO:0032922 circadian regulation of gene expression
GO:0045892 negative regulation of transcription, DNA-templated
GO:0045893 positive regulation of transcription, DNA-templated
GO:0045944 positive regulation of transcription from RNA polymerase II promoter
GO:0048511 rhythmic process
GO:0071320 cellular response to cAMP
GO:1904322 cellular response to forskolin
GO:1904613 cellular response to 2,3,7,8-tetrachlorodibenzodioxine

Cellular Component:
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0005667 transcription factor complex
GO:0005737 cytoplasm
GO:0005829 cytosol
GO:0032991 macromolecular complex
GO:0034751 aryl hydrocarbon receptor complex
GO:0034752 cytosolic aryl hydrocarbon receptor complex
GO:0034753 nuclear aryl hydrocarbon receptor complex


-  Descriptions from all associated GenBank mRNAs
  AK307495 - Homo sapiens cDNA, FLJ97443.
D16354 - Homo sapiens mRNA for Ah receptor, complete cds.
BC070080 - Homo sapiens aryl hydrocarbon receptor, mRNA (cDNA clone MGC:87401 IMAGE:30342582), complete cds.
JD565638 - Sequence 546662 from Patent EP1572962.
JD226622 - Sequence 207646 from Patent EP1572962.
JD075457 - Sequence 56481 from Patent EP1572962.
L19872 - Human AH-receptor mRNA, complete cds.
JD413849 - Sequence 394873 from Patent EP1572962.
JD280481 - Sequence 261505 from Patent EP1572962.
JD070950 - Sequence 51974 from Patent EP1572962.
BC069390 - Homo sapiens aryl hydrocarbon receptor, mRNA (cDNA clone MGC:97140 IMAGE:7262381), complete cds.
AB384754 - Synthetic construct DNA, clone: pF1KB3118, Homo sapiens AHR gene for aryl hydrocarbon receptor precursor, complete cds, without stop codon, in Flexi system.
JD021420 - Sequence 2444 from Patent EP1572962.
JD033054 - Sequence 14078 from Patent EP1572962.
JD357351 - Sequence 338375 from Patent EP1572962.
JD239011 - Sequence 220035 from Patent EP1572962.
BC021696 - Homo sapiens, clone IMAGE:4050637, mRNA.
JD181197 - Sequence 162221 from Patent EP1572962.
JD181868 - Sequence 162892 from Patent EP1572962.
JD555568 - Sequence 536592 from Patent EP1572962.
JD454487 - Sequence 435511 from Patent EP1572962.
JD299237 - Sequence 280261 from Patent EP1572962.
JD526379 - Sequence 507403 from Patent EP1572962.
JD233870 - Sequence 214894 from Patent EP1572962.
JD182240 - Sequence 163264 from Patent EP1572962.
AK130815 - Homo sapiens cDNA FLJ27305 fis, clone TMS05628.
JD566862 - Sequence 547886 from Patent EP1572962.
JD266272 - Sequence 247296 from Patent EP1572962.
JD325723 - Sequence 306747 from Patent EP1572962.
JD419385 - Sequence 400409 from Patent EP1572962.
JD419386 - Sequence 400410 from Patent EP1572962.
JD422334 - Sequence 403358 from Patent EP1572962.
JD422335 - Sequence 403359 from Patent EP1572962.
JD271267 - Sequence 252291 from Patent EP1572962.
JD271268 - Sequence 252292 from Patent EP1572962.
JD128660 - Sequence 109684 from Patent EP1572962.
JD087079 - Sequence 68103 from Patent EP1572962.
JD262082 - Sequence 243106 from Patent EP1572962.
JD165235 - Sequence 146259 from Patent EP1572962.
JD560958 - Sequence 541982 from Patent EP1572962.
JD542923 - Sequence 523947 from Patent EP1572962.
JD213091 - Sequence 194115 from Patent EP1572962.
JD152254 - Sequence 133278 from Patent EP1572962.
JD256790 - Sequence 237814 from Patent EP1572962.
JD407580 - Sequence 388604 from Patent EP1572962.
JD213093 - Sequence 194117 from Patent EP1572962.
JD337597 - Sequence 318621 from Patent EP1572962.
JD463117 - Sequence 444141 from Patent EP1572962.
JD514449 - Sequence 495473 from Patent EP1572962.
JD371287 - Sequence 352311 from Patent EP1572962.
JD337598 - Sequence 318622 from Patent EP1572962.
JD463119 - Sequence 444143 from Patent EP1572962.
JD367506 - Sequence 348530 from Patent EP1572962.
JD533858 - Sequence 514882 from Patent EP1572962.
JD376783 - Sequence 357807 from Patent EP1572962.
JD417718 - Sequence 398742 from Patent EP1572962.
JD279077 - Sequence 260101 from Patent EP1572962.
JD257008 - Sequence 238032 from Patent EP1572962.
JD421449 - Sequence 402473 from Patent EP1572962.
JD179067 - Sequence 160091 from Patent EP1572962.
JD133672 - Sequence 114696 from Patent EP1572962.
JD170143 - Sequence 151167 from Patent EP1572962.
JD322883 - Sequence 303907 from Patent EP1572962.
JD401451 - Sequence 382475 from Patent EP1572962.
JD188742 - Sequence 169766 from Patent EP1572962.
JD096420 - Sequence 77444 from Patent EP1572962.
JD096419 - Sequence 77443 from Patent EP1572962.
JD308892 - Sequence 289916 from Patent EP1572962.
JD308891 - Sequence 289915 from Patent EP1572962.
JD523111 - Sequence 504135 from Patent EP1572962.
JD405669 - Sequence 386693 from Patent EP1572962.
JD181437 - Sequence 162461 from Patent EP1572962.
JD091331 - Sequence 72355 from Patent EP1572962.

-  Biochemical and Signaling Pathways
  BioCarta from NCI Cancer Genome Anatomy Project
h_acrPathway - Ahr Signal Transduction Pathway

Reactome (by CSHL, EBI, and GO)

Protein P35869 (Reactome details) participates in the following event(s):

R-HSA-8936849 AHR:2xHSP90:AIP:PTGES3 binds TCDD
R-HSA-8937177 AHR:TCDD binds ARNT
R-HSA-8937191 AHR:TCDD:2xHSP90AB1:AIP:PTGES3 dissociates
R-HSA-8937144 Aryl hydrocarbon receptor signalling
R-HSA-211945 Phase I - Functionalization of compounds
R-HSA-211859 Biological oxidations
R-HSA-1430728 Metabolism

-  Other Names for This Gene
  Alternate Gene Symbols: A4D130, AHR , AHR_HUMAN, BHLHE76 , ENST00000242057.1, ENST00000242057.2, ENST00000242057.3, ENST00000242057.4, ENST00000242057.5, ENST00000242057.6, ENST00000242057.7, ENST00000242057.8, NM_001621, P35869, Q13728, Q13803, Q13804, uc317ejh.1, uc317ejh.2
UCSC ID: ENST00000242057.9_7
RefSeq Accession: NM_001621.5
Protein: P35869 (aka AHR_HUMAN)

-  Gene Model Information
  Click here for a detailed description of the fields of the table above.

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.