ID:AL1B1_HUMAN DESCRIPTION: RecName: Full=Aldehyde dehydrogenase X, mitochondrial; EC=1.2.1.3; AltName: Full=Aldehyde dehydrogenase 5; AltName: Full=Aldehyde dehydrogenase family 1 member B1; Flags: Precursor; FUNCTION: ALDHs play a major role in the detoxification of alcohol-derived acetaldehyde. They are involved in the metabolism of corticosteroids, biogenic amines, neurotransmitters, and lipid peroxidation. CATALYTIC ACTIVITY: An aldehyde + NAD(+) + H(2)O = a carboxylate + NADH. PATHWAY: Alcohol metabolism; ethanol degradation; acetate from ethanol: step 2/2. SUBUNIT: Homotetramer (By similarity). SUBCELLULAR LOCATION: Mitochondrion matrix. TISSUE SPECIFICITY: Liver, testis and to a lesser extent in brain. SIMILARITY: Belongs to the aldehyde dehydrogenase family.
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
ModBase Predicted Comparative 3D Structure on P30837
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
Gene Ontology (GO) Annotations with Structured Vocabulary
Molecular Function: GO:0004029 aldehyde dehydrogenase (NAD) activity GO:0016491 oxidoreductase activity GO:0016620 oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor GO:0051287 NAD binding