ID:ANR28_HUMAN DESCRIPTION: RecName: Full=Serine/threonine-protein phosphatase 6 regulatory ankyrin repeat subunit A; Short=PP6-ARS-A; Short=Serine/threonine-protein phosphatase 6 regulatory subunit ARS-A; AltName: Full=Ankyrin repeat domain-containing protein 28; AltName: Full=Phosphatase interactor targeting protein hnRNP K; Short=PITK; FUNCTION: Putative regulatory subunit of protein phosphatase 6 (PP6) that may be involved in the recognition of phosphoprotein substrates. Involved in the PP6-mediated dephosphorylation of NFKBIE opposing its degradation in response to TNF-alpha. Selectively inhibits the phosphatase activity of PPP1C. Targets PPP1C to modulate HNRPK phosphorylation. SUBUNIT: Protein phosphatase 6 (PP6) holoenzyme is proposed to be a heterotrimeric complex formed by the catalytic subunit, a SAPS domain-containing subunit (PP6R) and an ankyrin repeat-domain containing regulatory subunit (ARS). Interacts with PPP1C and HNRPK. Interacts with PPP6C, PPP6R1 and PPP6R3. INTERACTION: O00743:PPP6C; NbExp=3; IntAct=EBI-359567, EBI-359751; Q9UPN7:PPP6R1; NbExp=4; IntAct=EBI-359567, EBI-359745; Q5H9R7:PPP6R3; NbExp=3; IntAct=EBI-359567, EBI-355498; Q9H2K2:TNKS2; NbExp=3; IntAct=EBI-359567, EBI-4398527; SUBCELLULAR LOCATION: Nucleus, nucleoplasm. Note=Seems to be excluded from nucleoli. SIMILARITY: Contains 27 ANK repeats. SEQUENCE CAUTION: Sequence=AAQ72374.1; Type=Frameshift; Positions=408; Sequence=BAA20833.2; Type=Erroneous initiation; Note=Translation N-terminally shortened; Sequence=BAC86737.1; Type=Miscellaneous discrepancy; Note=Intron retention;
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
ModBase Predicted Comparative 3D Structure on O15084
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
US Server
Sequence and Links to Tools and Databases 
Common Gene Haplotype Alleles 
