Human Gene ANKS1A (ENST00000360359.5_6) from GENCODE V47lift37

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Description: ankyrin repeat and sterile alpha motif domain containing 1A (from RefSeq NM_015245.3)
Gencode Transcript: ENST00000360359.5_6
Gencode Gene: ENSG00000064999.16_11
Transcript (Including UTRs)
Position: hg19 chr6:34,857,032-35,059,183 Size: 202,152 Total Exon Count: 24 Strand: +
Coding Region
Position: hg19 chr6:34,857,180-35,056,386 Size: 199,207 Coding Exon Count: 24

Page Index	Sequence and Links	UniProtKB Comments	Primers	MalaCards	CTD
Gene Alleles	RNA-Seq Expression	Microarray Expression	RNA Structure	Protein Structure	Other Species
GO Annotations	mRNA Descriptions	Other Names	Model Information	Methods

Data last updated at UCSC: 2024-08-22 23:36:26

Sequence and Links to Tools and Databases

Genomic Sequence (chr6:34,857,032-35,059,183)			mRNA (may differ from genome)		Protein (1134 aa)
Gene Sorter	Genome Browser	Other Species FASTA	VisiGene	Gene interactions	Table Schema
AlphaFold	BioGPS	Ensembl	Entrez Gene	ExonPrimer	GeneCards
HGNC	Malacards	MGI	OMIM	PubMed	UniProtKB
Wikipedia	BioGrid CRISPR DB

Comments and Description Text from UniProtKB


	ID: ANS1A_HUMAN DESCRIPTION: RecName: Full=Ankyrin repeat and SAM domain-containing protein 1A; AltName: Full=Odin; FUNCTION: Regulator of different signaling pathways. Regulates EPHA8 receptor tyrosine kinase signaling to control cell migration and neurite retraction (By similarity). SUBUNIT: Interacts with EPHA8; EPHA8 kinase activity-independent but stimulated by EPHA8 ubiquitination (By similarity). SUBCELLULAR LOCATION: Cytoplasm. Cell projection (By similarity). Note=Cytoplasmic before and after growth factor treatment. TISSUE SPECIFICITY: Widely expressed (at protein level). PTM: Phosphorylated on tyrosine residues in response to EGF and PDGF (By similarity). SIMILARITY: Contains 6 ANK repeats. SIMILARITY: Contains 1 PID domain. SIMILARITY: Contains 2 SAM (sterile alpha motif) domains. SEQUENCE CAUTION: Sequence=BAA13218.1; Type=Erroneous initiation;

Primer design for this transcript

Primer3Plus can design qPCR Primers that straddle exon-exon-junctions, which amplify only cDNA, not genomic DNA.
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Exonprimer can design one pair of Sanger sequencing primers around every exon, located in non-genic sequence.
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To design primers for a non-coding sequence, zoom to a region of interest and select from the drop-down menu: View > In External Tools > Primer3

MalaCards Disease Associations


	MalaCards Gene Search: ANKS1A Diseases sorted by gene-association score: adjustment disorder (9)

Comparative Toxicogenomics Database (CTD)


	The following chemicals interact with this gene D015123 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide D000082 Acetaminophen D001564 Benzo(a)pyrene D003561 Cytarabine D004237 Diuron D006861 Hydrogen Peroxide D012999 Soman C044887 beta-methylcholine C069837 fullerene C60 C028007 nickel monoxide

Common Gene Haplotype Alleles


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RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)


	Highest median expression: 34.04 RPKM in Esophagus - Muscularis Total median expression: 585.55 RPKM View in GTEx track of Genome Browser View at GTEx portal View GTEx Body Map

Microarray Expression Data


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mRNA Secondary Structure of 3' and 5' UTRs

Region	Fold Energy	Bases	Energy/Base	Display As
5' UTR	-66.20	148	-0.447	Picture	PostScript	Text
3' UTR	-990.90	2797	-0.354	Picture	PostScript	Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

Protein Domain and Structure Information

InterPro Domains: Graphical view of domain structure
IPR002110 - Ankyrin_rpt
IPR020683 - Ankyrin_rpt-contain_dom
IPR011993 - PH_like_dom
IPR006020 - PTyr_interaction_dom
IPR001660 - SAM
IPR013761 - SAM/pointed
IPR021129 - SAM_type1

Pfam Domains:
PF00023 - Ankyrin repeat
PF00536 - SAM domain (Sterile alpha motif)
PF00640 - Phosphotyrosine interaction domain (PTB/PID)
PF07647 - SAM domain (Sterile alpha motif)
PF12796 - Ankyrin repeats (3 copies)
PF13606 - Ankyrin repeat
PF13637 - Ankyrin repeats (many copies)
PF13857 - Ankyrin repeats (many copies)

SCOP Domains:
140860 - Pseudo ankyrin repeat-like
47769 - SAM/Pointed domain
50729 - PH domain-like
53213 - LigB-like
55681 - Class II aaRS and biotin synthetases
48403 - Ankyrin repeat

Protein Data Bank (PDB) 3-D Structure
MuPIT help

2LMR - NMR MuPIT

ModBase Predicted Comparative 3D Structure on Q92625


Front	Top	Side

The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

Orthologous Genes in Other Species

Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.

Mouse	Rat	Zebrafish	D. melanogaster	C. elegans	S. cerevisiae
No ortholog	No ortholog	No ortholog	No ortholog	Genome Browser	No ortholog
Gene Details	Gene Details			Gene Details
Gene Sorter	Gene Sorter			Gene Sorter
	RGD			WormBase
				Protein Sequence
				Alignment

Gene Ontology (GO) Annotations with Structured Vocabulary


	Molecular Function: GO:0005515 protein binding GO:0046875 ephrin receptor binding Biological Process: GO:0006929 substrate-dependent cell migration GO:0016322 neuron remodeling GO:0048013 ephrin receptor signaling pathway GO:1901187 regulation of ephrin receptor signaling pathway Cellular Component: GO:0005654 nucleoplasm GO:0005737 cytoplasm GO:0005829 cytosol GO:0042995 cell projection GO:0043005 neuron projection

Descriptions from all associated GenBank mRNAs


	BC022396 - Homo sapiens ankyrin repeat and sterile alpha motif domain containing 1A, mRNA (cDNA clone IMAGE:4618556), partial cds. D86982 - Homo sapiens mRNA for KIAA0229 gene. BC031934 - Homo sapiens ankyrin repeat and sterile alpha motif domain containing 1A, mRNA (cDNA clone MGC:42354 IMAGE:4819948), complete cds. AK298987 - Homo sapiens cDNA FLJ60812 complete cds, highly similar to Ankyrin repeat and SAM domain-containing protein 1A. BC132832 - Homo sapiens ankyrin repeat and sterile alpha motif domain containing 1A, mRNA (cDNA clone MGC:164463 IMAGE:40146854), complete cds. BC144341 - Homo sapiens cDNA clone IMAGE:9052861, with apparent retained intron. AB385297 - Synthetic construct DNA, clone: pF1KA0229, Homo sapiens ANKS1A gene for ankyrin repeat and SAM domain-containing protein 1A, complete cds, without stop codon, in Flexi system. JD211267 - Sequence 192291 from Patent EP1572962. JD074972 - Sequence 55996 from Patent EP1572962. JD341671 - Sequence 322695 from Patent EP1572962. JD409217 - Sequence 390241 from Patent EP1572962. JD220505 - Sequence 201529 from Patent EP1572962. JD462527 - Sequence 443551 from Patent EP1572962. JD278938 - Sequence 259962 from Patent EP1572962. JC506674 - Sequence 42 from Patent EP2733220. JC506688 - Sequence 56 from Patent EP2733220. JC737786 - Sequence 42 from Patent WO2014075939. JC737800 - Sequence 56 from Patent WO2014075939. EF491787 - Homo sapiens clone ANKS1A/ODIN mRNA, partial sequence; alternatively spliced. DQ592437 - Homo sapiens piRNA piR-59549, complete sequence. DQ582836 - Homo sapiens piRNA piR-32948, complete sequence. BC049213 - Homo sapiens ankyrin repeat and sterile alpha motif domain containing 1A, mRNA (cDNA clone IMAGE:5528059). DQ599639 - Homo sapiens piRNA piR-37705, complete sequence. JD275877 - Sequence 256901 from Patent EP1572962. JD478803 - Sequence 459827 from Patent EP1572962. JD415433 - Sequence 396457 from Patent EP1572962. JD520399 - Sequence 501423 from Patent EP1572962. JD143262 - Sequence 124286 from Patent EP1572962. JD562732 - Sequence 543756 from Patent EP1572962. JD284351 - Sequence 265375 from Patent EP1572962. JD356125 - Sequence 337149 from Patent EP1572962. JD422095 - Sequence 403119 from Patent EP1572962. JD248291 - Sequence 229315 from Patent EP1572962. JD105433 - Sequence 86457 from Patent EP1572962. JD147482 - Sequence 128506 from Patent EP1572962. JD147904 - Sequence 128928 from Patent EP1572962. JD195123 - Sequence 176147 from Patent EP1572962. JD107760 - Sequence 88784 from Patent EP1572962. JD360503 - Sequence 341527 from Patent EP1572962. JD320193 - Sequence 301217 from Patent EP1572962. JD510761 - Sequence 491785 from Patent EP1572962. AK025381 - Homo sapiens cDNA: FLJ21728 fis, clone COLF1417. JD326618 - Sequence 307642 from Patent EP1572962. JD197190 - Sequence 178214 from Patent EP1572962. JD393216 - Sequence 374240 from Patent EP1572962. JD294596 - Sequence 275620 from Patent EP1572962. JD495331 - Sequence 476355 from Patent EP1572962. JD133138 - Sequence 114162 from Patent EP1572962. JD294812 - Sequence 275836 from Patent EP1572962. JD392257 - Sequence 373281 from Patent EP1572962. JD185012 - Sequence 166036 from Patent EP1572962. JD423383 - Sequence 404407 from Patent EP1572962. JD234735 - Sequence 215759 from Patent EP1572962. JD294590 - Sequence 275614 from Patent EP1572962. JD210857 - Sequence 191881 from Patent EP1572962. JD326469 - Sequence 307493 from Patent EP1572962. JD093913 - Sequence 74937 from Patent EP1572962. JD403724 - Sequence 384748 from Patent EP1572962. JD109564 - Sequence 90588 from Patent EP1572962. JD348352 - Sequence 329376 from Patent EP1572962. JD044041 - Sequence 25065 from Patent EP1572962. JD546392 - Sequence 527416 from Patent EP1572962. JD185502 - Sequence 166526 from Patent EP1572962. JD538762 - Sequence 519786 from Patent EP1572962. JD278228 - Sequence 259252 from Patent EP1572962. JD563974 - Sequence 544998 from Patent EP1572962. JD257264 - Sequence 238288 from Patent EP1572962. JD326401 - Sequence 307425 from Patent EP1572962. JD136458 - Sequence 117482 from Patent EP1572962. JD547098 - Sequence 528122 from Patent EP1572962. JD387300 - Sequence 368324 from Patent EP1572962. JD342625 - Sequence 323649 from Patent EP1572962. JD201224 - Sequence 182248 from Patent EP1572962. JD134968 - Sequence 115992 from Patent EP1572962. JD371646 - Sequence 352670 from Patent EP1572962. JD108427 - Sequence 89451 from Patent EP1572962. JD452910 - Sequence 433934 from Patent EP1572962. JD259692 - Sequence 240716 from Patent EP1572962. JD503550 - Sequence 484574 from Patent EP1572962. JD048315 - Sequence 29339 from Patent EP1572962.

Other Names for This Gene


	Alternate Gene Symbols: A2RUC1, ANKS1, ANS1A_HUMAN, B4DQW8, ENST00000360359.1, ENST00000360359.2, ENST00000360359.3, ENST00000360359.4, KIAA0229, NM_015245, ODIN, Q5JYI9, Q5SYR2, Q86WQ7, Q92625, uc318bmy.1, uc318bmy.2 UCSC ID: ENST00000360359.5_6 RefSeq Accession: NM_015245.3 Protein: Q92625 (aka ANS1A_HUMAN)

Gene Model Information


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Methods, Credits, and Use Restrictions


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