ID:AS3MT_HUMAN DESCRIPTION: RecName: Full=Arsenite methyltransferase; EC=2.1.1.137; AltName: Full=Methylarsonite methyltransferase; AltName: Full=S-adenosyl-L-methionine:arsenic(III) methyltransferase; FUNCTION: Catalyzes the transfer of a methyl group from AdoMet to trivalent arsenicals producing methylated and dimethylated arsenicals. It methylates arsenite to form methylarsonate, Me- AsO(3)H(2), which is reduced by methylarsonate reductase to methylarsonite, Me-As(OH)2. Methylarsonite is also a substrate and it is converted into the much less toxic compound dimethylarsinate (cacodylate), Me(2)As(O)-OH (By similarity). CATALYTIC ACTIVITY: S-adenosyl-L-methionine + arsenite = S- adenosyl-L-homocysteine + methylarsonate. CATALYTIC ACTIVITY: S-adenosyl-L-methionine + methylarsonite = S- adenosyl-L-homocysteine + dimethylarsinate. BIOPHYSICOCHEMICAL PROPERTIES: Kinetic parameters: KM=4.6 uM for sodium arsenite; KM=11.8 uM for AdoMet; SUBCELLULAR LOCATION: Cytoplasm (By similarity). SIMILARITY: Belongs to the methyltransferase superfamily. SEQUENCE CAUTION: Sequence=AAG09731.1; Type=Frameshift; Positions=333;
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
ModBase Predicted Comparative 3D Structure on Q9HBK9
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
US Server
Sequence and Links to Tools and Databases 
Common Gene Haplotype Alleles 
