ID:ATG10_HUMAN DESCRIPTION: RecName: Full=Ubiquitin-like-conjugating enzyme ATG10; EC=6.3.2.-; AltName: Full=Autophagy-related protein 10; Short=APG10-like; FUNCTION: E2-like enzyme involved in autophagy. Acts as an E2-like enzyme that catalyzes the conjugation of ATG12 to ATG5. ATG12 conjugation to ATG5 is required for autophagy. Likely serves as an ATG5-recognition molecule. Not involved in ATG12 conjugation to ATG3 (By similarity). SUBUNIT: Interacts with MAP1LC3A. By interacting with MAP1LC3A, it plays a role in the conjugation of ATG12 to ATG5. Also able to directly interact either with ATG5 or ATG7 (By similarity). INTERACTION: O94817:ATG12; NbExp=1; IntAct=EBI-1048913, EBI-746742; O95166:GABARAP; NbExp=1; IntAct=EBI-1048913, EBI-712001; Q9H0R8:GABARAPL1; NbExp=1; IntAct=EBI-1048913, EBI-746969; P60520:GABARAPL2; NbExp=1; IntAct=EBI-1048913, EBI-720116; Q9GZQ8:MAP1LC3B; NbExp=1; IntAct=EBI-1048913, EBI-373144; Q9BXW4:MAP1LC3C; NbExp=1; IntAct=EBI-1048913, EBI-2603996; SUBCELLULAR LOCATION: Cytoplasm (Probable). SIMILARITY: Belongs to the ATG10 family. SEQUENCE CAUTION: Sequence=BC004551; Type=Frameshift; Positions=26; Sequence=BC027718; Type=Frameshift; Positions=26;
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
ModBase Predicted Comparative 3D Structure on Q9H0Y0
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
Biological Process: GO:0006497 protein lipidation GO:0006914 autophagy GO:0006983 ER overload response GO:0015031 protein transport GO:0016236 macroautophagy GO:0031401 positive regulation of protein modification process GO:0032446 protein modification by small protein conjugation
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Sequence and Links to Tools and Databases 
Common Gene Haplotype Alleles 
