ID:APC15_HUMAN DESCRIPTION: RecName: Full=Anaphase-promoting complex subunit 15; Short=APC15; FUNCTION: Component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin ligase that controls progression through mitosis and the G1 phase of the cell cycle. In the complex, plays a role in the release of the mitotic checkpoint complex (MCC) from the APC/C: not required for APC/C activity itself, but promotes the turnover of CDC20 and MCC on the APC/C, thereby participating to the responsiveness of the spindle assembly checkpoint. Also required for degradation of CDC20. SUBUNIT: The APC/C is composed of at least 12 subunits. SIMILARITY: Belongs to the APC15 family. SEQUENCE CAUTION: Sequence=EAW74842.1; Type=Erroneous gene model prediction;
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
ModBase Predicted Comparative 3D Structure on P60006
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
AK311146 - Homo sapiens cDNA, FLJ18188. AK222622 - Homo sapiens mRNA, hypothetical protein LOC25906 variant, clone: CAS11095. BC005156 - Homo sapiens chromosome 11 open reading frame 51, mRNA (cDNA clone MGC:4245 IMAGE:2964612), complete cds. AF077206 - Homo sapiens HSPC020 mRNA, complete cds. BC005393 - Homo sapiens chromosome 11 open reading frame 51, mRNA (cDNA clone MGC:12527 IMAGE:4051407), complete cds. AL080071 - Homo sapiens mRNA; cDNA DKFZp564M082 (from clone DKFZp564M082). JD253116 - Sequence 234140 from Patent EP1572962. JD084800 - Sequence 65824 from Patent EP1572962. JD565551 - Sequence 546575 from Patent EP1572962. JD019381 - Sequence 405 from Patent EP1572962. JD154717 - Sequence 135741 from Patent EP1572962. JD230636 - Sequence 211660 from Patent EP1572962. JD097965 - Sequence 78989 from Patent EP1572962. JD134962 - Sequence 115986 from Patent EP1572962. JD095142 - Sequence 76166 from Patent EP1572962. JD054564 - Sequence 35588 from Patent EP1572962. JD107049 - Sequence 88073 from Patent EP1572962. EU831644 - Synthetic construct Homo sapiens clone HAIB:100066673; DKFZo007F0619 chromosome 11 open reading frame 51 protein (C11orf51) gene, encodes complete protein. HQ447908 - Synthetic construct Homo sapiens clone IMAGE:100071264; CCSB005557_03 chromosome 11 open reading frame 51 (C11orf51) gene, encodes complete protein. KJ893488 - Synthetic construct Homo sapiens clone ccsbBroadEn_02882 C11orf51 gene, encodes complete protein. KJ898569 - Synthetic construct Homo sapiens clone ccsbBroadEn_07963 C11orf51 gene, encodes complete protein. EU831728 - Synthetic construct Homo sapiens clone HAIB:100066757; DKFZo003F0620 chromosome 11 open reading frame 51 protein (C11orf51) gene, encodes complete protein. CU675155 - Synthetic construct Homo sapiens gateway clone IMAGE:100018513 5' read C11orf51 mRNA. JD442647 - Sequence 423671 from Patent EP1572962. JD040085 - Sequence 21109 from Patent EP1572962. JD316223 - Sequence 297247 from Patent EP1572962. JD166343 - Sequence 147367 from Patent EP1572962. JD409160 - Sequence 390184 from Patent EP1572962.
Biochemical and Signaling Pathways
Reactome (by CSHL, EBI, and GO)
Protein P60006 (Reactome details) participates in the following event(s):
R-HSA-174119 Free APC/C phosphorylated by Plk1 R-HSA-174132 Free APC/C phosphorylated by Cyclin B:Cdc2 R-HSA-174139 Dissociation of phospho-Cdh1 from the APC/C complex R-HSA-141423 Binding of the MCC complex to the APC/C complex R-HSA-174070 Association of Cdh1 with the APC/C R-HSA-174224 Dissociation of Cdc20 from APC/C complex R-HSA-174057 Multiubiquitination of APC/C-associated Cdh1 R-HSA-188371 Association of Cyclin A:Cdk2 with Cdh1 R-HSA-3788708 CDKN1A (p21) prevents association of Cyclin A:Cdk2 with Cdh1 R-HSA-3788725 Cdh1:APC/C complex binds EHMT1:EHMT2 R-HSA-174171 Association of Cyclin A with the APC/C R-HSA-174238 Activation of APC/C:Cdc20 by dissociation of Cdc20:phospho-APC/C from Cdc20:phospho-APC/C:Mad2:Bub3:BubR1 R-HSA-179410 Association of Nek2A with MCC:APC/C R-HSA-174120 Association of Cyclin B:Cdc2 with Cdc20:APC/C complex R-HSA-174121 Association of Securin with Cdc20:APC/C complex R-HSA-174088 Association of cell cycle proteins with the APC/C:Cdh1 complex R-HSA-174079 Phosphorylation of Cdh1 by Cyclin A:Cdk2 R-HSA-3788705 CDKN1A (p21) prevents phosphorylation of Cdh1 by Cyclin A:Cdk2 R-HSA-3788724 Cdh1:APC/C ubiquitinates EHMT1 and EHMT2 R-HSA-174104 Ubiquitination of Cyclin A by APC/C:Cdc20 complex R-HSA-179417 Multiubiquitination of Nek2A R-HSA-174227 Ubiquitination of Cyclin B by phospho-APC/C:Cdc20 complex R-HSA-174144 Ubiquitination of Securin by phospho-APC/C:Cdc20 complex R-HSA-174195 Ubiquitination of cell cycle proteins targeted by the APC/C:Cdh1complex R-HSA-69015 Cytoplasmic phosphorylated Cdc6 is ubiquitinated by the anaphase-promoting complex R-HSA-176412 Phosphorylation of the APC/C R-HSA-174084 Autodegradation of Cdh1 by Cdh1:APC/C R-HSA-176408 Regulation of APC/C activators between G1/S and early anaphase R-HSA-141430 Inactivation of APC/C via direct inhibition of the APC/C complex R-HSA-176407 Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase R-HSA-176814 Activation of APC/C and APC/C:Cdc20 mediated degradation of mitotic proteins R-HSA-2559582 Senescence-Associated Secretory Phenotype (SASP) R-HSA-174143 APC/C-mediated degradation of cell cycle proteins R-HSA-174184 Cdc20:Phospho-APC/C mediated degradation of Cyclin A R-HSA-176409 APC/C:Cdc20 mediated degradation of mitotic proteins R-HSA-179409 APC-Cdc20 mediated degradation of Nek2A R-HSA-174048 APC/C:Cdc20 mediated degradation of Cyclin B R-HSA-174154 APC/C:Cdc20 mediated degradation of Securin R-HSA-2467813 Separation of Sister Chromatids R-HSA-174178 APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1 R-HSA-141405 Inhibition of the proteolytic activity of APC/C required for the onset of anaphase by mitotic spindle checkpoint components R-HSA-2559583 Cellular Senescence R-HSA-453276 Regulation of mitotic cell cycle R-HSA-179419 APC:Cdc20 mediated degradation of cell cycle proteins prior to satisfation of the cell cycle checkpoint R-HSA-68882 Mitotic Anaphase R-HSA-69017 CDK-mediated phosphorylation and removal of Cdc6 R-HSA-69618 Mitotic Spindle Checkpoint R-HSA-2262752 Cellular responses to stress R-HSA-69278 Cell Cycle (Mitotic) R-HSA-2555396 Mitotic Metaphase and Anaphase R-HSA-69052 Switching of origins to a post-replicative state R-HSA-69620 Cell Cycle Checkpoints R-HSA-8953897 Cellular responses to external stimuli R-HSA-1640170 Cell Cycle R-HSA-68886 M Phase R-HSA-69239 Synthesis of DNA R-HSA-69242 S Phase R-HSA-69306 DNA Replication
US Server
Sequence and Links to Tools and Databases 
Common Gene Haplotype Alleles 
