ID:CCAR1_HUMAN DESCRIPTION: RecName: Full=Cell division cycle and apoptosis regulator protein 1; AltName: Full=Cell cycle and apoptosis regulatory protein 1; Short=CARP-1; AltName: Full=Death inducer with SAP domain; FUNCTION: Associates with components of the Mediator and p160 coactivator complexes that play a role as intermediaries transducing regulatory signals from upstream transcriptional activator proteins to basal transcription machinery at the core promoter. Recruited to endogenous nuclear receptor target genes in response to the appropriate hormone. Also functions as a p53 coactivator. May thus play an important role in transcriptional regulation (By similarity). May be involved in apoptosis signaling in the presence of the reinoid CD437. Apoptosis induction involves sequestration of 14-3-3 protein(s) and mediated altered expression of multiple cell cycle regulatory genes including MYC, CCNB1 and CDKN1A. Plays a role in cell cycle progression and/or cell proliferation. SUBUNIT: Directly interacts with CALCOCO1, ESR1, NR3C1 and TP53 (By similarity). INTERACTION: Q9GZV5:WWTR1; NbExp=2; IntAct=EBI-356265, EBI-747743; Q9EPK5:Wwtr1 (xeno); NbExp=5; IntAct=EBI-356265, EBI-1211920; SUBCELLULAR LOCATION: Cytoplasm, perinuclear region. TISSUE SPECIFICITY: Expressed in various epithelial cancer cell lines, including breast, colon, prostate, pancreatic and leukemia. Expression is regulated by growth factors. PTM: Phosphorylated upon DNA damage, probably by ATM or ATR. SIMILARITY: Contains 1 SAP domain. SEQUENCE CAUTION: Sequence=AAH26036.1; Type=Miscellaneous discrepancy; Note=Contaminating sequence. Potential poly-A sequence; Sequence=AAI08683.1; Type=Miscellaneous discrepancy; Note=Contaminating sequence. Potential poly-A sequence; Sequence=BAA91354.1; Type=Erroneous initiation;
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
ModBase Predicted Comparative 3D Structure on Q8IX12
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
AK023438 - Homo sapiens cDNA FLJ13376 fis, clone PLACE1000849. AF465616 - Homo sapiens death inducer with SAP domain DIS mRNA, complete cds. AK307550 - Homo sapiens cDNA, FLJ97498. AK298004 - Homo sapiens cDNA FLJ53148 partial cds, highly similar to Cell division cycle and apoptosis regulator protein 1. BC058846 - Homo sapiens cell division cycle and apoptosis regulator 1, mRNA (cDNA clone IMAGE:4248900), partial cds. AK001701 - Homo sapiens cDNA FLJ10839 fis, clone NT2RP4001276. AY249140 - Homo sapiens cell-cycle and apoptosis regulatory protein 1 mRNA, complete cds. AK292649 - Homo sapiens cDNA FLJ76727 partial cds, highly similar to Homo sapiens cell division cycle and apoptosis regulator 1 (CCAR1), mRNA. AK307704 - Homo sapiens cDNA, FLJ97652. AK122871 - Homo sapiens cDNA FLJ16505 fis, clone FEBRA2015076. AK299307 - Homo sapiens cDNA FLJ55631 partial cds, highly similar to Cell division cycle and apoptosis regulator protein 1. AK307671 - Homo sapiens cDNA, FLJ97619. BX647943 - Homo sapiens mRNA; cDNA DKFZp686B1451 (from clone DKFZp686B1451). BC130626 - Homo sapiens cell division cycle and apoptosis regulator 1, mRNA (cDNA clone MGC:163498 IMAGE:40146657), complete cds. BC132725 - Homo sapiens cell division cycle and apoptosis regulator 1, mRNA (cDNA clone MGC:164356 IMAGE:40146747), complete cds. BC144118 - Homo sapiens cDNA clone IMAGE:9052638. BC108682 - Homo sapiens cell division cycle and apoptosis regulator 1, mRNA (cDNA clone IMAGE:6165670), partial cds. BC026036 - Homo sapiens cell division cycle and apoptosis regulator 1, mRNA (cDNA clone IMAGE:5020111), partial cds. BC089420 - Homo sapiens cell division cycle and apoptosis regulator 1, mRNA (cDNA clone IMAGE:3100686), partial cds. AK000741 - Homo sapiens cDNA FLJ20734 fis, clone HEP08523. AK001452 - Homo sapiens cDNA FLJ10590 fis, clone NT2RP2004392, weakly similar to MNN4 PROTEIN. BC015475 - Homo sapiens cell division cycle and apoptosis regulator 1, mRNA (cDNA clone IMAGE:3887184), partial cds. AF086334 - Homo sapiens full length insert cDNA clone ZD55D10. JD355665 - Sequence 336689 from Patent EP1572962. AK128100 - Homo sapiens cDNA FLJ46221 fis, clone TESTI4013852. JD090350 - Sequence 71374 from Patent EP1572962. JD181581 - Sequence 162605 from Patent EP1572962. JD263362 - Sequence 244386 from Patent EP1572962. JD422080 - Sequence 403104 from Patent EP1572962. JD105652 - Sequence 86676 from Patent EP1572962. JD158937 - Sequence 139961 from Patent EP1572962. JD158938 - Sequence 139962 from Patent EP1572962. JD208729 - Sequence 189753 from Patent EP1572962. JD208730 - Sequence 189754 from Patent EP1572962. JD112123 - Sequence 93147 from Patent EP1572962. JD488600 - Sequence 469624 from Patent EP1572962.
Biochemical and Signaling Pathways
Reactome (by CSHL, EBI, and GO)
Protein Q8IX12 (Reactome details) participates in the following event(s):
R-HSA-72107 Formation of the Spliceosomal E complex R-HSA-72143 Lariat Formation and 5'-Splice Site Cleavage R-HSA-72139 Formation of the active Spliceosomal C (B*) complex R-HSA-72124 Formation of the Spliceosomal A Complex R-HSA-72127 Formation of the Spliceosomal B Complex R-HSA-72130 Formation of an intermediate Spliceosomal C (Bact) complex R-HSA-156661 Formation of Exon Junction Complex R-HSA-72163 mRNA Splicing - Major Pathway R-HSA-72172 mRNA Splicing R-HSA-72203 Processing of Capped Intron-Containing Pre-mRNA R-HSA-8953854 Metabolism of RNA
US Server
Sequence and Links to Tools and Databases 
Common Gene Haplotype Alleles 
