Human Gene CCDC137 (ENST00000329214.13_5) from GENCODE V48lift37

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Description: coiled-coil domain containing 137 (from RefSeq NM_199287.3)
Gencode Transcript: ENST00000329214.13_5
Gencode Gene: ENSG00000185298.13_10
Transcript (Including UTRs)
Position: hg19 chr17:79,633,767-79,640,929 Size: 7,163 Total Exon Count: 6 Strand: +
Coding Region
Position: hg19 chr17:79,633,797-79,639,734 Size: 5,938 Coding Exon Count: 6

Page Index	Sequence and Links	Primers	CTD	Gene Alleles	RNA-Seq Expression
RNA Structure	Protein Structure	Other Species	GO Annotations	mRNA Descriptions	Other Names
Model Information	Methods

Data last updated at UCSC: 2025-04-10 15:10:12

Sequence and Links to Tools and Databases

Genomic Sequence (chr17:79,633,767-79,640,929)			mRNA (may differ from genome)		Protein (289 aa)
Gene Sorter	Genome Browser	Other Species FASTA	Gene interactions	Table Schema	AlphaFold
BioGPS	Ensembl	Entrez Gene	ExonPrimer	GeneCards	HGNC
MGI	neXtProt	OMIM	PubMed	UniProtKB	Wikipedia
BioGrid CRISPR DB

Primer design for this transcript

Primer3Plus can design qPCR Primers that straddle exon-exon-junctions, which amplify only cDNA, not genomic DNA.
Click here to load the transcript sequence and exon structure into Primer3Plus

Exonprimer can design one pair of Sanger sequencing primers around every exon, located in non-genic sequence.
Click here to open Exonprimer with this transcript

To design primers for a non-coding sequence, zoom to a region of interest and select from the drop-down menu: View > In External Tools > Primer3

Comparative Toxicogenomics Database (CTD)


	The following chemicals interact with this gene D016604 Aflatoxin B1 C532162 2-(1H-indazol-4-yl)-6-(4-methanesulfonylpiperazin-1-ylmethyl)-4-morpholin-4-ylthieno(3,2-d)pyrimidine D000082 Acetaminophen D001564 Benzo(a)pyrene D003300 Copper D006861 Hydrogen Peroxide D008070 Lipopolysaccharides C558013 NSC 689534 D013749 Tetrachlorodibenzodioxin C006253 pirinixic acid

Common Gene Haplotype Alleles


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RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)


	Highest median expression: 22.47 RPKM in Skin - Not Sun Exposed (Suprapubic) Total median expression: 526.18 RPKM View in GTEx track of Genome Browser View at GTEx portal View GTEx Body Map

mRNA Secondary Structure of 3' and 5' UTRs

Region	Fold Energy	Bases	Energy/Base	Display As
5' UTR	-11.30	30	-0.377	Picture	PostScript	Text
3' UTR	-478.30	1195	-0.400	Picture	PostScript	Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

Protein Domain and Structure Information

InterPro Domains: Graphical view of domain structure
IPR026680 - CCDC137

ModBase Predicted Comparative 3D Structure on Q6PK04


Front	Top	Side

The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

Orthologous Genes in Other Species

Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.

Mouse	Rat	Zebrafish	D. melanogaster	C. elegans	S. cerevisiae
No ortholog	No ortholog	No ortholog	No ortholog	No ortholog	No ortholog
Gene Details	Gene Details
Gene Sorter	Gene Sorter
	RGD

Gene Ontology (GO) Annotations with Structured Vocabulary


	Molecular Function: GO:0003723 RNA binding GO:0005515 protein binding Cellular Component: GO:0001650 fibrillar center GO:0005694 chromosome GO:0005730 nucleolus

Descriptions from all associated GenBank mRNAs


	FJ649645 - Homo sapiens hepatocellular carcinoma related protein 2 mRNA, complete cds. LF384825 - JP 2014500723-A/192328: Polycomb-Associated Non-Coding RNAs. BC009369 - Homo sapiens coiled-coil domain containing 137, mRNA (cDNA clone MGC:16597 IMAGE:4110481), complete cds. CU679329 - Synthetic construct Homo sapiens gateway clone IMAGE:100022424 5' read CCDC137 mRNA. HQ447697 - Synthetic construct Homo sapiens clone IMAGE:100071025; CCSB013476_01 coiled-coil domain containing 137 (CCDC137) gene, encodes complete protein. KJ896057 - Synthetic construct Homo sapiens clone ccsbBroadEn_05451 CCDC137 gene, encodes complete protein. LF328584 - JP 2014500723-A/136087: Polycomb-Associated Non-Coding RNAs. LF328585 - JP 2014500723-A/136088: Polycomb-Associated Non-Coding RNAs. JD204886 - Sequence 185910 from Patent EP1572962. JD189612 - Sequence 170636 from Patent EP1572962. LF328586 - JP 2014500723-A/136089: Polycomb-Associated Non-Coding RNAs. JD339596 - Sequence 320620 from Patent EP1572962. BC052272 - Homo sapiens cDNA clone IMAGE:6671315, partial cds. JD544069 - Sequence 525093 from Patent EP1572962. JD392385 - Sequence 373409 from Patent EP1572962. JD137992 - Sequence 119016 from Patent EP1572962. JD451258 - Sequence 432282 from Patent EP1572962. JD172772 - Sequence 153796 from Patent EP1572962. JD140095 - Sequence 121119 from Patent EP1572962. JD542570 - Sequence 523594 from Patent EP1572962. JD212440 - Sequence 193464 from Patent EP1572962. JD197835 - Sequence 178859 from Patent EP1572962. JD412843 - Sequence 393867 from Patent EP1572962. JD512818 - Sequence 493842 from Patent EP1572962. JD238805 - Sequence 219829 from Patent EP1572962. JD187614 - Sequence 168638 from Patent EP1572962. JD441904 - Sequence 422928 from Patent EP1572962. JD421660 - Sequence 402684 from Patent EP1572962. JD158996 - Sequence 140020 from Patent EP1572962. JD208788 - Sequence 189812 from Patent EP1572962. MA620402 - JP 2018138019-A/192328: Polycomb-Associated Non-Coding RNAs. MA564161 - JP 2018138019-A/136087: Polycomb-Associated Non-Coding RNAs. MA564162 - JP 2018138019-A/136088: Polycomb-Associated Non-Coding RNAs. MA564163 - JP 2018138019-A/136089: Polycomb-Associated Non-Coding RNAs.

Other Names for This Gene


	Alternate Gene Symbols: CC137_HUMAN, cPERP-B , ENST00000329214.1, ENST00000329214.10, ENST00000329214.11, ENST00000329214.12, ENST00000329214.2, ENST00000329214.3, ENST00000329214.4, ENST00000329214.5, ENST00000329214.6, ENST00000329214.7, ENST00000329214.8, ENST00000329214.9, NM_199287, Q6PK04, uc317srk.1, uc317srk.2 UCSC ID: ENST00000329214.13_5 RefSeq Accession: NM_199287.3 Protein: Q6PK04 (aka CC137_HUMAN)

Gene Model Information


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Methods, Credits, and Use Restrictions


	Click here for details on how this gene model was made and data restrictions if any.