Human Gene CD7 (ENST00000312648.8_10) from GENCODE V47lift37

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Description: CD7 molecule (from RefSeq NM_006137.7)
Gencode Transcript: ENST00000312648.8_10
Gencode Gene: ENSG00000173762.9_12
Transcript (Including UTRs)
Position: hg19 chr17:80,272,749-80,275,484 Size: 2,736 Total Exon Count: 4 Strand: -
Coding Region
Position: hg19 chr17:80,273,197-80,275,371 Size: 2,175 Coding Exon Count: 4

Page Index	Sequence and Links	Primers	MalaCards	CTD	Gene Alleles
RNA-Seq Expression	Microarray Expression	RNA Structure	Protein Structure	Other Species	GO Annotations
mRNA Descriptions	Pathways	Other Names	Model Information	Methods

Data last updated at UCSC: 2024-08-22 23:36:26

Sequence and Links to Tools and Databases

Genomic Sequence (chr17:80,272,749-80,275,484)			mRNA (may differ from genome)		Protein (240 aa)
Gene Sorter	Genome Browser	Other Species FASTA	VisiGene	Gene interactions	Table Schema
AlphaFold	BioGPS	Ensembl	Entrez Gene	ExonPrimer	GeneCards
HGNC	Malacards	MGI	OMIM	PubMed	UniProtKB
Wikipedia	BioGrid CRISPR DB

Primer design for this transcript

Primer3Plus can design qPCR Primers that straddle exon-exon-junctions, which amplify only cDNA, not genomic DNA.
Click here to load the transcript sequence and exon structure into Primer3Plus

Exonprimer can design one pair of Sanger sequencing primers around every exon, located in non-genic sequence.
Click here to open Exonprimer with this transcript

To design primers for a non-coding sequence, zoom to a region of interest and select from the drop-down menu: View > In External Tools > Primer3

MalaCards Disease Associations


	MalaCards Gene Search: CD7 Diseases sorted by gene-association score: pityriasis lichenoides et varioliformis acuta (9), t-cell leukemia (8), mycosis fungoides (6), pityriasis lichenoides (4), acute t cell leukemia (4), adult t-cell leukemia (3), sezary's disease (3), retinitis pigmentosa 72 (3), hepatosplenic t-cell lymphoma (3), leukemia, acute lymphoblastic (2), inflammatory bowel disease 16 (2), t-cell prolymphocytic leukemia (2), retinitis pigmentosa-50 (2), colon lymphoma (1), leukemia, acute myeloid (1), follicular mucinosis (1), aleukemic leukemia cutis (1), thymic dysplasia (1), small intestine lymphoma (1), chronic nk-cell lymphocytosis (1), retinitis pigmentosa 26 (1), exanthema subitum (1)

Comparative Toxicogenomics Database (CTD)


	The following chemicals interact with this gene D013749 Tetrachlorodibenzodioxin D001554 Benzene D001564 Benzo(a)pyrene D002117 Calcitriol D003907 Dexamethasone D004997 Ethinyl Estradiol D005620 Freund's Adjuvant D009151 Mustard Gas D010615 Phenacetin D011374 Progesterone more ... click here to view the complete list

Common Gene Haplotype Alleles


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RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)


	Highest median expression: 29.00 RPKM in Whole Blood Total median expression: 95.73 RPKM View in GTEx track of Genome Browser View at GTEx portal View GTEx Body Map

Microarray Expression Data


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mRNA Secondary Structure of 3' and 5' UTRs

Region	Fold Energy	Bases	Energy/Base	Display As
5' UTR	-50.20	113	-0.444	Picture	PostScript	Text
3' UTR	-167.00	448	-0.373	Picture	PostScript	Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

Protein Domain and Structure Information

InterPro Domains: Graphical view of domain structure
IPR007110 - Ig-like
IPR013783 - Ig-like_fold
IPR003599 - Ig_sub
IPR013106 - Ig_V-set

Pfam Domains:
PF07686 - Immunoglobulin V-set domain

SCOP Domains:
48726 - Immunoglobulin

ModBase Predicted Comparative 3D Structure on Q29VG3


Front	Top	Side

The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

Orthologous Genes in Other Species

Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.

Mouse	Rat	Zebrafish	D. melanogaster	C. elegans	S. cerevisiae
No ortholog	No ortholog	No ortholog	No ortholog	No ortholog	No ortholog
Gene Details	Gene Details
Gene Sorter	Gene Sorter
	RGD

Gene Ontology (GO) Annotations with Structured Vocabulary


	Cellular Component: GO:0016020 membrane GO:0016021 integral component of membrane

Descriptions from all associated GenBank mRNAs


	AK310558 - Homo sapiens cDNA, FLJ17600. BC009293 - Homo sapiens CD7 molecule, mRNA (cDNA clone MGC:16622 IMAGE:4120480), complete cds. BC013297 - Homo sapiens CD7 molecule, mRNA (cDNA clone MGC:3929 IMAGE:3529600), complete cds. AY935534 - Homo sapiens clone 18 CD7 antigen mRNA, complete cds. AY935535 - Homo sapiens clone 14 CD7 antigen mRNA, complete cds. AY935536 - Homo sapiens clone 32 CD7 antigen mRNA, complete cds. AY935537 - Homo sapiens clone 5240 CD7 antigen mRNA, complete cds. LP896085 - Sequence 949 from Patent EP3253886. X06180 - Human mRNA for CD7 antigen (gp40). JD209987 - Sequence 191011 from Patent EP1572962. JD390385 - Sequence 371409 from Patent EP1572962. AK223465 - Homo sapiens mRNA for CD7 antigen precursor variant, clone: FCC117E08. DQ890740 - Synthetic construct clone IMAGE:100003370; FLH165592.01X; RZPDo839E04160D CD7 molecule (CD7) gene, encodes complete protein. DQ892590 - Synthetic construct clone IMAGE:100005220; FLH187870.01X; RZPDo839D12150D CD7 molecule (CD7) gene, encodes complete protein. DQ893911 - Synthetic construct Homo sapiens clone IMAGE:100008371; FLH165588.01L; RZPDo839E04159D CD7 molecule (CD7) gene, encodes complete protein. DQ895810 - Synthetic construct Homo sapiens clone IMAGE:100010270; FLH187866.01L; RZPDo839D12149D CD7 molecule (CD7) gene, encodes complete protein. KJ890854 - Synthetic construct Homo sapiens clone ccsbBroadEn_00248 CD7 gene, encodes complete protein. BT006696 - Homo sapiens CD7 antigen (p41) mRNA, complete cds. AK310061 - Homo sapiens cDNA, FLJ17103. AK298096 - Homo sapiens cDNA FLJ57491 complete cds, moderately similar to T-cell antigen CD7 precursor.

Biochemical and Signaling Pathways


	BioCarta from NCI Cancer Genome Anatomy Project h_dcPathway - Dendritic cells in regulating TH1 and TH2 Development

Other Names for This Gene


	Alternate Gene Symbols: CD7 , ENST00000312648.1, ENST00000312648.2, ENST00000312648.3, ENST00000312648.4, ENST00000312648.5, ENST00000312648.6, ENST00000312648.7, hCG_18659 , NM_006137, Q29VG3, Q29VG3_HUMAN, uc317pgn.1, uc317pgn.2 UCSC ID: ENST00000312648.8_10 RefSeq Accession: NM_006137.7 Protein: Q29VG3

Gene Model Information


	Click here for a detailed description of the fields of the table above.

Methods, Credits, and Use Restrictions


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