Human Gene CDK2AP2 (ENST00000301488.8_7) from GENCODE V47lift37

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Description: cyclin dependent kinase 2 associated protein 2, transcript variant 1 (from RefSeq NM_005851.5)
Gencode Transcript: ENST00000301488.8_7
Gencode Gene: ENSG00000167797.8_8
Transcript (Including UTRs)
Position: hg19 chr11:67,273,968-67,275,633 Size: 1,666 Total Exon Count: 4 Strand: -
Coding Region
Position: hg19 chr11:67,274,416-67,275,553 Size: 1,138 Coding Exon Count: 4

Page Index	Sequence and Links	Primers	CTD	Gene Alleles	RNA-Seq Expression
Microarray Expression	RNA Structure	Protein Structure	Other Species	GO Annotations	mRNA Descriptions
Other Names	Model Information	Methods

Data last updated at UCSC: 2024-08-22 23:36:26

Sequence and Links to Tools and Databases

Genomic Sequence (chr11:67,273,968-67,275,633)			mRNA (may differ from genome)		Protein (126 aa)
Gene Sorter	Genome Browser	Other Species FASTA	VisiGene	Gene interactions	Table Schema
AlphaFold	BioGPS	Ensembl	Entrez Gene	ExonPrimer	GeneCards
HGNC	MGI	PubMed	UniProtKB	BioGrid CRISPR DB

Primer design for this transcript

Primer3Plus can design qPCR Primers that straddle exon-exon-junctions, which amplify only cDNA, not genomic DNA.
Click here to load the transcript sequence and exon structure into Primer3Plus

Exonprimer can design one pair of Sanger sequencing primers around every exon, located in non-genic sequence.
Click here to open Exonprimer with this transcript

To design primers for a non-coding sequence, zoom to a region of interest and select from the drop-down menu: View > In External Tools > Primer3

Comparative Toxicogenomics Database (CTD)


	The following chemicals interact with this gene D013749 Tetrachlorodibenzodioxin C006780 bisphenol A C517041 (4-amino-1,4-dihydro-3-(2-pyridyl)-5-thioxo-1,2,4-triazole)copper(II) C029497 2,3-bis(3'-hydroxybenzyl)butyrolactone D000082 Acetaminophen D016604 Aflatoxin B1 D001564 Benzo(a)pyrene D002084 Butylated Hydroxytoluene D002922 Ciguatoxins D002945 Cisplatin more ... click here to view the complete list

Common Gene Haplotype Alleles


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RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)


	Highest median expression: 55.07 RPKM in Thyroid Total median expression: 1348.18 RPKM View in GTEx track of Genome Browser View at GTEx portal View GTEx Body Map

Microarray Expression Data


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mRNA Secondary Structure of 3' and 5' UTRs

Region	Fold Energy	Bases	Energy/Base	Display As
5' UTR	-37.40	80	-0.468	Picture	PostScript	Text
3' UTR	-136.20	448	-0.304	Picture	PostScript	Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

Protein Domain and Structure Information

InterPro Domains: Graphical view of domain structure
IPR017266 - CDK2-associated_2
IPR019187 - Cyclin-dep_kinase2-assoc_pr

Pfam Domains:
PF09806 - Cyclin-dependent kinase 2-associated protein

ModBase Predicted Comparative 3D Structure on Q6IAV4


Front	Top	Side

The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

Orthologous Genes in Other Species

Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.

Mouse	Rat	Zebrafish	D. melanogaster	C. elegans	S. cerevisiae
No ortholog	No ortholog	No ortholog	No ortholog	No ortholog	No ortholog
Gene Details	Gene Details
Gene Sorter	Gene Sorter
	RGD	Ensembl

Gene Ontology (GO) Annotations with Structured Vocabulary


	Molecular Function: GO:0005515 protein binding GO:0016301 kinase activity Biological Process: GO:0016310 phosphorylation GO:0070507 regulation of microtubule cytoskeleton organization GO:2000035 regulation of stem cell division Cellular Component: GO:0005634 nucleus GO:0005737 cytoplasm GO:0005874 microtubule

Descriptions from all associated GenBank mRNAs


	BC002850 - Homo sapiens cyclin-dependent kinase 2 associated protein 2, mRNA (cDNA clone MGC:3779 IMAGE:3659410), complete cds. AK001498 - Homo sapiens cDNA FLJ10636 fis, clone NT2RP2005675, highly similar to Cyclin-dependent kinase 2-associated protein 2. BC016704 - Homo sapiens cyclin-dependent kinase 2 associated protein 2, mRNA (cDNA clone MGC:22912 IMAGE:4075420), complete cds. AF089814 - Homo sapiens growth suppressor related (DOC-1R) mRNA, complete cds. JD349496 - Sequence 330520 from Patent EP1572962. JD399858 - Sequence 380882 from Patent EP1572962. JD423022 - Sequence 404046 from Patent EP1572962. JD107328 - Sequence 88352 from Patent EP1572962. JD098546 - Sequence 79570 from Patent EP1572962. AK310197 - Homo sapiens cDNA, FLJ17239. JD415478 - Sequence 396502 from Patent EP1572962. JD370170 - Sequence 351194 from Patent EP1572962. JD121620 - Sequence 102644 from Patent EP1572962. JD219593 - Sequence 200617 from Patent EP1572962. JD130949 - Sequence 111973 from Patent EP1572962. JD128238 - Sequence 109262 from Patent EP1572962. CR457050 - Homo sapiens full open reading frame cDNA clone RZPDo834C0615D for gene DOC-1R, tumor suppressor deleted in oral cancer-related 1; complete cds, incl. stopcodon. BT006909 - Homo sapiens tumor suppressor deleted in oral cancer-related 1 mRNA, complete cds. KJ892981 - Synthetic construct Homo sapiens clone ccsbBroadEn_02375 CDK2AP2 gene, encodes complete protein. CR542042 - Homo sapiens full open reading frame cDNA clone RZPDo834C0336D for gene DOC-1R, tumor suppressor deleted in oral cancer-related 1; complete cds, without stopcodon. AK308725 - Homo sapiens cDNA, FLJ98766. JD206457 - Sequence 187481 from Patent EP1572962. JD117403 - Sequence 98427 from Patent EP1572962. JD387696 - Sequence 368720 from Patent EP1572962. JD458674 - Sequence 439698 from Patent EP1572962. JD406094 - Sequence 387118 from Patent EP1572962.

Other Names for This Gene


	Alternate Gene Symbols: CDK2AP2 , DOC-1R , ENST00000301488.1, ENST00000301488.2, ENST00000301488.3, ENST00000301488.4, ENST00000301488.5, ENST00000301488.6, ENST00000301488.7, hCG_21052 , NM_005851, Q6IAV4, Q6IAV4_HUMAN, uc317mve.1, uc317mve.2 UCSC ID: ENST00000301488.8_7 RefSeq Accession: NM_005851.5 Protein: Q6IAV4

Gene Model Information


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Methods, Credits, and Use Restrictions


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