ID:CEBPG_HUMAN DESCRIPTION: RecName: Full=CCAAT/enhancer-binding protein gamma; Short=C/EBP gamma; FUNCTION: Transcription factor that binds to the enhancer element PRE-I (positive regulatory element-I) of the IL-4 gene. Might change the DNA-binding specificity of other transcription factors and recruit them to unusual DNA sites. SUBUNIT: Binds DNA as a dimer and can form stable heterodimers with C/EBP alpha and beta and with Fos protein. Interacts with ZNF638; this interaction increases transcriptional activation (By similarity). SUBCELLULAR LOCATION: Nucleus. SIMILARITY: Belongs to the bZIP family. C/EBP subfamily. SIMILARITY: Contains 1 bZIP (basic-leucine zipper) domain.
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
ModBase Predicted Comparative 3D Structure on P53567
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
Gene Ontology (GO) Annotations with Structured Vocabulary
Molecular Function: GO:0000978 RNA polymerase II core promoter proximal region sequence-specific DNA binding GO:0000981 RNA polymerase II transcription factor activity, sequence-specific DNA binding GO:0001077 transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding GO:0003677 DNA binding GO:0003700 transcription factor activity, sequence-specific DNA binding GO:0005515 protein binding GO:0008134 transcription factor binding GO:0042803 protein homodimerization activity GO:0043565 sequence-specific DNA binding GO:0046982 protein heterodimerization activity
Biological Process: GO:0001889 liver development GO:0006351 transcription, DNA-templated GO:0006355 regulation of transcription, DNA-templated GO:0006357 regulation of transcription from RNA polymerase II promoter GO:0006366 transcription from RNA polymerase II promoter GO:0006955 immune response GO:0016071 mRNA metabolic process GO:0030183 B cell differentiation GO:0042267 natural killer cell mediated cytotoxicity GO:0043353 enucleate erythrocyte differentiation GO:0043388 positive regulation of DNA binding GO:0043433 negative regulation of sequence-specific DNA binding transcription factor activity GO:0045078 positive regulation of interferon-gamma biosynthetic process GO:0045739 positive regulation of DNA repair GO:0045944 positive regulation of transcription from RNA polymerase II promoter GO:0051091 positive regulation of sequence-specific DNA binding transcription factor activity
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Sequence and Links to Tools and Databases 
Common Gene Haplotype Alleles 
