ID:CH3L1_HUMAN DESCRIPTION: RecName: Full=Chitinase-3-like protein 1; AltName: Full=39 kDa synovial protein; AltName: Full=Cartilage glycoprotein 39; Short=CGP-39; Short=GP-39; Short=hCGP-39; AltName: Full=YKL-40; Flags: Precursor; FUNCTION: Carbohydrate-binding lectin with a preference for chitin. May play a role in defense against pathogens, or in tissue remodeling. May play an important role in the capacity of cells to respond to and cope with changes in their environment. SUBUNIT: Monomer. SUBCELLULAR LOCATION: Secreted, extracellular space. TISSUE SPECIFICITY: Present in activated macrophages, articular chondrocytes, synovial cells as well as in liver. Undetectable in muscle tissues, lung, pancreas, mononuclear cells, or fibroblasts. PTM: Glycosylated. DISEASE: A genetic variation in CHI3L1 is associated with susceptibility to asthma-related traits type 7 (ASRT7) [MIM:611960]. Asthma-related traits include clinical symptoms of asthma, such as coughing, wheezing and dyspnea, bronchial hyperresponsiveness (BHR) as assessed by methacholine challenge test, serum IgE levels, atopy, and atopic dermatitis. SIMILARITY: Belongs to the glycosyl hydrolase 18 family.
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
ModBase Predicted Comparative 3D Structure on P36222
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
Biological Process: GO:0005975 carbohydrate metabolic process GO:0006915 apoptotic process GO:0006954 inflammatory response GO:0007250 activation of NF-kappaB-inducing kinase activity GO:0009612 response to mechanical stimulus GO:0010800 positive regulation of peptidyl-threonine phosphorylation GO:0030324 lung development GO:0034612 response to tumor necrosis factor GO:0043312 neutrophil degranulation GO:0045766 positive regulation of angiogenesis GO:0051216 cartilage development GO:0051897 positive regulation of protein kinase B signaling GO:0070374 positive regulation of ERK1 and ERK2 cascade GO:0070555 response to interleukin-1 GO:0070741 response to interleukin-6 GO:0071347 cellular response to interleukin-1 GO:0071356 cellular response to tumor necrosis factor GO:0072606 interleukin-8 secretion GO:0006032 chitin catabolic process
US Server
Sequence and Links to Tools and Databases 
Common Gene Haplotype Alleles 
