ID:ACHA5_HUMAN DESCRIPTION: RecName: Full=Neuronal acetylcholine receptor subunit alpha-5; Flags: Precursor; FUNCTION: After binding acetylcholine, the AChR responds by an extensive change in conformation that affects all subunits and leads to opening of an ion-conducting channel across the plasma membrane. SUBUNIT: Neuronal AChR seems to be composed of two different type of subunits: alpha and non-alpha (beta). SUBCELLULAR LOCATION: Cell junction, synapse, postsynaptic cell membrane; Multi-pass membrane protein. Cell membrane; Multi-pass membrane protein. POLYMORPHISM: Genetic variations in CHRNA5 have been associated with susceptibility to smoking-related behavioral traits and lung cancer, contributing to the smoking quantitative trait locus 3 (SQTL3) [MIM:612052]. SIMILARITY: Belongs to the ligand-gated ion channel (TC 1.A.9) family. Acetylcholine receptor (TC 1.A.9.1) subfamily. Alpha- 5/CHRNA5 sub-subfamily.
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
ModBase Predicted Comparative 3D Structure on P30532
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
Gene Ontology (GO) Annotations with Structured Vocabulary
Molecular Function: GO:0004888 transmembrane signaling receptor activity GO:0005216 ion channel activity GO:0005230 extracellular ligand-gated ion channel activity GO:0005515 protein binding GO:0015276 ligand-gated ion channel activity GO:0015464 acetylcholine receptor activity GO:0022848 acetylcholine-gated cation-selective channel activity GO:0042166 acetylcholine binding
Biological Process: GO:0006811 ion transport GO:0007165 signal transduction GO:0007268 chemical synaptic transmission GO:0007271 synaptic transmission, cholinergic GO:0007274 neuromuscular synaptic transmission GO:0034220 ion transmembrane transport GO:0035094 response to nicotine GO:0035095 behavioral response to nicotine GO:0060078 regulation of postsynaptic membrane potential GO:0060079 excitatory postsynaptic potential
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Sequence and Links to Tools and Databases 
Common Gene Haplotype Alleles 
