ID:CNGA2_HUMAN DESCRIPTION: RecName: Full=Cyclic nucleotide-gated olfactory channel; AltName: Full=Cyclic nucleotide-gated cation channel 2; AltName: Full=Cyclic nucleotide-gated channel alpha-2; Short=CNG channel alpha-2; Short=CNG-2; Short=CNG2; FUNCTION: Odorant signal transduction is probably mediated by a G- protein coupled cascade using cAMP as second messenger. The olfactory channel can be shown to be activated by cyclic nucleotides which leads to a depolarization of olfactory sensory neurons. SUBCELLULAR LOCATION: Membrane; Multi-pass membrane protein. SIMILARITY: Belongs to the cyclic nucleotide-gated cation channel (TC 1.A.1.5) family. CNGA2 subfamily. SIMILARITY: Contains 1 cyclic nucleotide-binding domain.
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
ModBase Predicted Comparative 3D Structure on Q16280
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
Biological Process: GO:0006811 ion transport GO:0007608 sensory perception of smell GO:0034220 ion transmembrane transport GO:0042391 regulation of membrane potential GO:0050896 response to stimulus GO:0055085 transmembrane transport GO:0071805 potassium ion transmembrane transport
AK128186 - Homo sapiens cDNA FLJ46312 fis, clone TESTI4040559, highly similar to Homo sapiens cyclic nucleotide gated channel alpha 2 (CNGA2), mRNA. BC126302 - Homo sapiens cyclic nucleotide gated channel alpha 2, mRNA (cDNA clone MGC:161580 IMAGE:8992018), complete cds. BC126304 - Homo sapiens cyclic nucleotide gated channel alpha 2, mRNA (cDNA clone MGC:161582 IMAGE:8992020), complete cds.
Biochemical and Signaling Pathways
Reactome (by CSHL, EBI, and GO)
Protein Q16280 (Reactome details) participates in the following event(s):
R-HSA-5620914 ARF4:GTP binds VxPx-motifs of membrane proteins R-HSA-5620918 ASAP1 dimer binds membrane proteins R-HSA-5623519 RAB3IP and RAB8A bind to the ciliary targeting complex R-HSA-5623513 ASAP1 stimulates GTPase activity of ARF4 R-HSA-5620921 ASAP1 recruits RAB11FIP3 and RAB11 to the ciliary targeting complex R-HSA-5623521 RAB3IP stimulates nucleotide exchange on RAB8A R-HSA-5623524 The exocyst complex binds to RAB3IP in the ciliary targeting complex R-HSA-5620916 VxPx cargo-targeting to cilium R-HSA-5620920 Cargo trafficking to the periciliary membrane R-HSA-5617833 Cilium Assembly R-HSA-1852241 Organelle biogenesis and maintenance