Human Gene CNTLN (ENST00000380647.8_10) from GENCODE V47lift37
  Description: centlein, transcript variant 1 (from RefSeq NM_017738.4)
Gencode Transcript: ENST00000380647.8_10
Gencode Gene: ENSG00000044459.15_12
Transcript (Including UTRs)
   Position: hg19 chr9:17,135,038-17,503,921 Size: 368,884 Total Exon Count: 26 Strand: +
Coding Region
   Position: hg19 chr9:17,135,064-17,502,650 Size: 367,587 Coding Exon Count: 26 

Page IndexSequence and LinksUniProtKB CommentsPrimersMalaCardsCTD
Gene AllelesRNA-Seq ExpressionMicroarray ExpressionRNA StructureProtein StructureOther Species
GO AnnotationsmRNA DescriptionsOther NamesModel InformationMethods
Data last updated at UCSC: 2024-08-22 23:36:26

-  Sequence and Links to Tools and Databases
 
Genomic Sequence (chr9:17,135,038-17,503,921)mRNA (may differ from genome)Protein (1406 aa)
Gene SorterGenome BrowserOther Species FASTAGene interactionsTable SchemaAlphaFold
BioGPSEnsemblEntrez GeneExonPrimerGeneCardsHGNC
MalacardsMGIOMIMPubMedUniProtKBWikipedia
BioGrid CRISPR DB

-  Comments and Description Text from UniProtKB
  ID: CNTLN_HUMAN
DESCRIPTION: RecName: Full=Centlein; AltName: Full=Centrosomal protein;
SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton, centrosome, centriole. Note=Colocalizes with gamma-tubulin during interphase and mitosis. Appears to associated with the mother centriole during G1 phase and with daughter centrioles towards G1/S phase (By similarity).
SEQUENCE CAUTION: Sequence=BAA91052.1; Type=Erroneous initiation; Note=Translation N-terminally extended; Sequence=BAB13850.1; Type=Erroneous initiation; Note=Translation N-terminally extended;

-  Primer design for this transcript
 

Primer3Plus can design qPCR Primers that straddle exon-exon-junctions, which amplify only cDNA, not genomic DNA.
Click here to load the transcript sequence and exon structure into Primer3Plus

Exonprimer can design one pair of Sanger sequencing primers around every exon, located in non-genic sequence.
Click here to open Exonprimer with this transcript

To design primers for a non-coding sequence, zoom to a region of interest and select from the drop-down menu: View > In External Tools > Primer3


-  MalaCards Disease Associations
  MalaCards Gene Search: CNTLN
Diseases sorted by gene-association score: microcephalic osteodysplastic primordial dwarfism, type ii (8), meesmann corneal dystrophy (6), seckel syndrome (4), growth hormone deficiency, isolated, type ia (4), bardet-biedl syndrome 2 (4), meckel syndrome 1 (1), joubert syndrome 1 (1), leber congenital amaurosis (1)

-  Comparative Toxicogenomics Database (CTD)
  The following chemicals interact with this gene           more ... click here to view the complete list

+  Common Gene Haplotype Alleles
  Press "+" in the title bar above to open this section.

-  RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
  Highest median expression: 2.91 RPKM in Ovary
Total median expression: 58.26 RPKM



View in GTEx track of Genome Browser    View at GTEx portal     View GTEx Body Map

+  Microarray Expression Data
  Press "+" in the title bar above to open this section.

-  mRNA Secondary Structure of 3' and 5' UTRs
 
RegionFold EnergyBasesEnergy/Base
Display As
5' UTR -1.8026-0.069 Picture PostScript Text
3' UTR -259.601271-0.204 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Protein Domain and Structure Information
  InterPro Domains: Graphical view of domain structure
IPR003661 - Sig_transdc_His_kin_sub1_dim/P

SCOP Domains:
101447 - Formin homology 2 domain (FH2 domain)

ModBase Predicted Comparative 3D Structure on Q9NXG0
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The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
MouseRatZebrafishD. melanogasterC. elegansS. cerevisiae
No orthologNo orthologNo orthologNo orthologNo orthologNo ortholog
Gene DetailsGene Details    
Gene SorterGene Sorter    
 RGDEnsembl   
      
      

-  Gene Ontology (GO) Annotations with Structured Vocabulary
  Molecular Function:
GO:0019901 protein kinase binding
GO:0019904 protein domain specific binding
GO:0030674 protein binding, bridging

Biological Process:
GO:0010457 centriole-centriole cohesion
GO:0033365 protein localization to organelle

Cellular Component:
GO:0005654 nucleoplasm
GO:0005737 cytoplasm
GO:0005813 centrosome
GO:0005814 centriole
GO:0005829 cytosol
GO:0005856 cytoskeleton
GO:0070062 extracellular exosome


-  Descriptions from all associated GenBank mRNAs
  AK308837 - Homo sapiens cDNA, FLJ98878.
BX647069 - Homo sapiens mRNA; cDNA DKFZp686K1269 (from clone DKFZp686K1269).
AK098502 - Homo sapiens cDNA FLJ25636 fis, clone STM04338.
BC156251 - Synthetic construct Homo sapiens clone IMAGE:100061645, MGC:190063 centlein, centrosomal protein (CNTLN) mRNA, encodes complete protein.
AK000283 - Homo sapiens cDNA FLJ20276 fis, clone HEP02437.
AK021596 - Homo sapiens cDNA FLJ11534 fis, clone HEMBA1002679.
AK303973 - Homo sapiens cDNA FLJ61043 complete cds.
JD202019 - Sequence 183043 from Patent EP1572962.
JD423543 - Sequence 404567 from Patent EP1572962.
JD096801 - Sequence 77825 from Patent EP1572962.
JD305980 - Sequence 287004 from Patent EP1572962.
JD175502 - Sequence 156526 from Patent EP1572962.
JD040666 - Sequence 21690 from Patent EP1572962.
JD379015 - Sequence 360039 from Patent EP1572962.
JD255088 - Sequence 236112 from Patent EP1572962.
JD060856 - Sequence 41880 from Patent EP1572962.
JD546414 - Sequence 527438 from Patent EP1572962.
JD363945 - Sequence 344969 from Patent EP1572962.
JD546798 - Sequence 527822 from Patent EP1572962.
JD554003 - Sequence 535027 from Patent EP1572962.

-  Other Names for This Gene
  Alternate Gene Symbols: A5Z2X6, C9orf101, C9orf39, CNTLN_HUMAN, ENST00000380647.1, ENST00000380647.2, ENST00000380647.3, ENST00000380647.4, ENST00000380647.5, ENST00000380647.6, ENST00000380647.7, NM_017738, Q5VYJ0, Q8N1G9, Q9HAJ5, Q9NXG0, uc318pta.1, uc318pta.2
UCSC ID: ENST00000380647.8_10
RefSeq Accession: NM_017738.4
Protein: Q9NXG0 (aka CNTLN_HUMAN)

-  Gene Model Information
  Click here for a detailed description of the fields of the table above.

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.