ID:CNTP1_HUMAN DESCRIPTION: RecName: Full=Contactin-associated protein 1; Short=Caspr; Short=Caspr1; AltName: Full=Neurexin IV; AltName: Full=Neurexin-4; AltName: Full=p190; Flags: Precursor; FUNCTION: Seems to play a role in the formation of functional distinct domains critical for saltatory conduction of nerve impulses in myelinated nerve fibers. Seems to demarcate the paranodal region of the axo-glial junction. In association with contactin may have a role in the signaling between axons and myelinating glial cells. SUBUNIT: Interacts with contactin in cis form. INTERACTION: P16333:NCK1; NbExp=2; IntAct=EBI-1751903, EBI-389883; SUBCELLULAR LOCATION: Membrane; Single-pass type I membrane protein (Potential). TISSUE SPECIFICITY: Predominantly expressed in brain. Weak expression detected in ovary, pancreas, colon, lung, heart, intestine and testis. SIMILARITY: Belongs to the neurexin family. SIMILARITY: Contains 2 EGF-like domains. SIMILARITY: Contains 1 F5/8 type C domain. SIMILARITY: Contains 1 fibrinogen C-terminal domain. SIMILARITY: Contains 4 laminin G-like domains.
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
ModBase Predicted Comparative 3D Structure on P78357
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
Biological Process: GO:0002175 protein localization to paranode region of axon GO:0007010 cytoskeleton organization GO:0007155 cell adhesion GO:0007165 signal transduction GO:0009967 positive regulation of signal transduction GO:0019227 neuronal action potential propagation GO:0022010 central nervous system myelination GO:0022011 myelination in peripheral nervous system GO:0030913 paranodal junction assembly GO:0031175 neuron projection development GO:0048812 neuron projection morphogenesis GO:0050884 neuromuscular process controlling posture GO:0050885 neuromuscular process controlling balance GO:0071205 protein localization to juxtaparanode region of axon
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Sequence and Links to Tools and Databases 
Common Gene Haplotype Alleles 
