Human Gene COA1 (ENST00000223336.11_9) from GENCODE V47lift37
  Description: cytochrome c oxidase assembly factor 1, transcript variant 39 (from RefSeq NR_163915.1)
Gencode Transcript: ENST00000223336.11_9
Gencode Gene: ENSG00000106603.20_13
Transcript (Including UTRs)
   Position: hg19 chr7:43,678,856-43,769,122 Size: 90,267 Total Exon Count: 6 Strand: -
Coding Region
   Position: hg19 chr7:43,679,181-43,688,213 Size: 9,033 Coding Exon Count: 5 

Page IndexSequence and LinksUniProtKB CommentsPrimersCTDGene Alleles
RNA-Seq ExpressionMicroarray ExpressionRNA StructureProtein StructureOther SpeciesGO Annotations
mRNA DescriptionsOther NamesModel InformationMethods
Data last updated at UCSC: 2024-08-22 23:36:26

-  Sequence and Links to Tools and Databases
 
Genomic Sequence (chr7:43,678,856-43,769,122)mRNA (may differ from genome)Protein (146 aa)
Gene SorterGenome BrowserOther Species FASTAGene interactionsTable SchemaAlphaFold
BioGPSEnsemblEntrez GeneExonPrimerGeneCardsHGNC
MGIOMIMPubMedUniProtKBBioGrid CRISPR DB

-  Comments and Description Text from UniProtKB
  ID: COA1_HUMAN
DESCRIPTION: RecName: Full=Cytochrome oxidase assembly protein 1 homolog;
SUBUNIT: Interacts with COX17 and C1orf31.
SUBCELLULAR LOCATION: Mitochondrion membrane; Single-pass membrane protein.
SIMILARITY: Belongs to the COA1 family.

-  Primer design for this transcript
 

Primer3Plus can design qPCR Primers that straddle exon-exon-junctions, which amplify only cDNA, not genomic DNA.
Click here to load the transcript sequence and exon structure into Primer3Plus

Exonprimer can design one pair of Sanger sequencing primers around every exon, located in non-genic sequence.
Click here to open Exonprimer with this transcript

To design primers for a non-coding sequence, zoom to a region of interest and select from the drop-down menu: View > In External Tools > Primer3


-  Comparative Toxicogenomics Database (CTD)
  The following chemicals interact with this gene           more ... click here to view the complete list

+  Common Gene Haplotype Alleles
  Press "+" in the title bar above to open this section.

-  RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
  Highest median expression: 5.86 RPKM in Cells - EBV-transformed lymphocytes
Total median expression: 150.38 RPKM



View in GTEx track of Genome Browser    View at GTEx portal     View GTEx Body Map

+  Microarray Expression Data
  Press "+" in the title bar above to open this section.

-  mRNA Secondary Structure of 3' and 5' UTRs
 
RegionFold EnergyBasesEnergy/Base
Display As
5' UTR -40.20133-0.302 Picture PostScript Text
3' UTR -71.10325-0.219 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Protein Domain and Structure Information
  InterPro Domains: Graphical view of domain structure
IPR014807 - Cyt_oxidase_assembly-1

Pfam Domains:
PF08695 - Cytochrome oxidase complex assembly protein 1

ModBase Predicted Comparative 3D Structure on Q9GZY4
FrontTopSide
The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
MouseRatZebrafishD. melanogasterC. elegansS. cerevisiae
No orthologNo orthologNo orthologNo orthologNo orthologNo ortholog
   Gene DetailsGene Details 
   Gene SorterGene Sorter 
  Ensembl WormBase 
      
      

-  Gene Ontology (GO) Annotations with Structured Vocabulary
  Molecular Function:
GO:0003723 RNA binding
GO:0003735 structural constituent of ribosome

Biological Process:
GO:0006412 translation
GO:0032981 mitochondrial respiratory chain complex I assembly
GO:0033617 mitochondrial respiratory chain complex IV assembly

Cellular Component:
GO:0005739 mitochondrion
GO:0005743 mitochondrial inner membrane
GO:0005829 cytosol
GO:0016020 membrane
GO:0016021 integral component of membrane
GO:0022625 cytosolic large ribosomal subunit
GO:0031305 integral component of mitochondrial inner membrane


-  Descriptions from all associated GenBank mRNAs
  AK023053 - Homo sapiens cDNA FLJ12991 fis, clone NT2RP3000134.
AK293043 - Homo sapiens cDNA FLJ77808 complete cds.
AK023007 - Homo sapiens cDNA FLJ12945 fis, clone NT2RP2005227.
AK001665 - Homo sapiens cDNA FLJ10803 fis, clone NT2RP4000833.
AK124008 - Homo sapiens cDNA FLJ42014 fis, clone SPLEN2032356.
AK129690 - Homo sapiens cDNA FLJ26179 fis, clone ADG04184.
AK097203 - Homo sapiens cDNA FLJ39884 fis, clone SPLEN2016304.
BC056884 - Homo sapiens chromosome 7 open reading frame 44, mRNA (cDNA clone MGC:65006 IMAGE:6159045), complete cds.
AK021905 - Homo sapiens cDNA FLJ11843 fis, clone HEMBA1006659.
JD320196 - Sequence 301220 from Patent EP1572962.
JD559620 - Sequence 540644 from Patent EP1572962.
JD448978 - Sequence 430002 from Patent EP1572962.
HQ448644 - Synthetic construct Homo sapiens clone IMAGE:100072083; CCSB011999_02 chromosome 7 open reading frame 44 (C7orf44) gene, encodes complete protein.
KJ894252 - Synthetic construct Homo sapiens clone ccsbBroadEn_03646 C7orf44 gene, encodes complete protein.
CU691174 - Synthetic construct Homo sapiens gateway clone IMAGE:100021509 5' read C7orf44 mRNA.
AK309315 - Homo sapiens cDNA, FLJ99356.
AK308911 - Homo sapiens cDNA, FLJ98952.

-  Other Names for This Gene
  Alternate Gene Symbols: A6NJU8, A8KAH8, C7orf44, COA1 , COA1_HUMAN, ENST00000223336.1, ENST00000223336.10, ENST00000223336.2, ENST00000223336.3, ENST00000223336.4, ENST00000223336.5, ENST00000223336.6, ENST00000223336.7, ENST00000223336.8, ENST00000223336.9, MITRAC15, NR_163915, Q9GZY4, Q9HAB7, Q9NVD2, uc317dhe.1, uc317dhe.2
UCSC ID: ENST00000223336.11_9
RefSeq Accession: NM_018224.4
Protein: Q9GZY4 (aka COA1_HUMAN)

-  Gene Model Information
  Click here for a detailed description of the fields of the table above.

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.