ID:CR3L1_HUMAN DESCRIPTION: RecName: Full=Cyclic AMP-responsive element-binding protein 3-like protein 1; Short=cAMP-responsive element-binding protein 3-like protein 1; AltName: Full=Old astrocyte specifically-induced substance; Short=OASIS; Contains: RecName: Full=Processed cyclic AMP-responsive element-binding protein 3-like protein 1; FUNCTION: Transcription factor that acts during endoplasmic reticulum stress by activating unfolded protein response target genes. Specifically involved in ER-stress response in astrocytes in the central nervous system (By similartity). May play a role in gliosis. In vitro, binds to box-B element, cAMP response element (CRE) and CRE-like sequences, and activates transcription through box-B element but not through CRE (By similarity). SUBCELLULAR LOCATION: Endoplasmic reticulum membrane; Single-pass type II membrane protein. SUBCELLULAR LOCATION: Processed cyclic AMP-responsive element- binding protein 3-like protein 1: Nucleus. Note=Under ER stress the cleaved N-terminal cytoplasmic domain translocates into the nucleus. TISSUE SPECIFICITY: Ubiquitously expressed with high levels in pancreas and prostate. Expressed at relatively lower levels in brain. PTM: Controlled by regulated intramembrane proteolysis (RIP). Following ER stress a fragment containing the cytoplasmic transcription factor domain is released by proteolysis. The cleavage is performed sequentially by site-1 and site-2 proteases (PS1 and PS2) and is triggered by translocation to the Golgi apparatus. SIMILARITY: Belongs to the bZIP family. ATF subfamily. SIMILARITY: Contains 1 bZIP (basic-leucine zipper) domain. SEQUENCE CAUTION: Sequence=BAC11681.1; Type=Erroneous initiation;
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
SCOP Domains: 47454 - A DNA-binding domain in eukaryotic transcription factors 57959 - Leucine zipper domain
ModBase Predicted Comparative 3D Structure on Q96BA8
Front
Top
Side
The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.
Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
Gene Ontology (GO) Annotations with Structured Vocabulary
Molecular Function: GO:0000981 RNA polymerase II transcription factor activity, sequence-specific DNA binding GO:0001077 transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding GO:0001227 transcriptional repressor activity, RNA polymerase II transcription regulatory region sequence-specific binding GO:0003677 DNA binding GO:0003682 chromatin binding GO:0003700 transcription factor activity, sequence-specific DNA binding GO:0005515 protein binding GO:0035497 cAMP response element binding GO:0044212 transcription regulatory region DNA binding GO:0046332 SMAD binding
Biological Process: GO:0000122 negative regulation of transcription from RNA polymerase II promoter GO:0001649 osteoblast differentiation GO:0006351 transcription, DNA-templated GO:0006355 regulation of transcription, DNA-templated GO:0006366 transcription from RNA polymerase II promoter GO:0006986 response to unfolded protein GO:0007275 multicellular organism development GO:0010629 negative regulation of gene expression GO:0030968 endoplasmic reticulum unfolded protein response GO:0032967 positive regulation of collagen biosynthetic process GO:0040037 negative regulation of fibroblast growth factor receptor signaling pathway GO:0045892 negative regulation of transcription, DNA-templated GO:0045944 positive regulation of transcription from RNA polymerase II promoter GO:0070278 extracellular matrix constituent secretion GO:1902236 negative regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway GO:1903671 negative regulation of sprouting angiogenesis GO:1990440 positive regulation of transcription from RNA polymerase II promoter in response to endoplasmic reticulum stress
US Server
Sequence and Links to Tools and Databases 
Common Gene Haplotype Alleles 
