ID:CTCFL_HUMAN DESCRIPTION: RecName: Full=Transcriptional repressor CTCFL; AltName: Full=Brother of the regulator of imprinted sites; AltName: Full=CCCTC-binding factor; AltName: Full=CTCF paralog; AltName: Full=CTCF-like protein; AltName: Full=Cancer/testis antigen 27; Short=CT27; AltName: Full=Zinc finger protein CTCF-T; FUNCTION: Testis-specific DNA binding protein responsible for insulator function, nuclear architecture and transcriptional control, which probably acts by recruiting epigenetic chromatin modifiers. Plays a key role in gene imprinting in male germline, by participating in the establishment of differential methylation at the IGF2/H19 imprinted control region (ICR). Directly binds the unmethylated H19 ICR and recruits the PRMT7 methyltransferase, leading to methylate histone H4 'Arg-3' to form H4R3sme2. This probably leads to recruit de novo DNA methyltransferases at these sites (By similarity). Seems to act as tumor suppressor. In association with DNMT1 and DNMT3B, involved in activation of BAG1 gene expression by binding to its promoter. Required for dimethylation of H3 lysine 4 (H3K4me2) of MYC and BRCA1 promoters. SUBUNIT: Interacts with histones, PRMT7 and SETD1A. Interacts (via N-terminus) with BAG6/BAT3. SUBCELLULAR LOCATION: Cytoplasm. Nucleus. TISSUE SPECIFICITY: Testis specific. Specifically expressed in primary spermatocytes. DEVELOPMENTAL STAGE: Is up-regulated in primary spermatocytes (expression overlapping with the genome-wide erasure of methylation) to become silenced on activation of CTCF in post- meiotic germline cells (expression corresponding to DNA remethylation). SIMILARITY: Belongs to the CTCF zinc-finger protein family. SIMILARITY: Contains 11 C2H2-type zinc fingers.
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
ModBase Predicted Comparative 3D Structure on Q8NI51
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
Gene Ontology (GO) Annotations with Structured Vocabulary
Molecular Function: GO:0000978 RNA polymerase II core promoter proximal region sequence-specific DNA binding GO:0000981 RNA polymerase II transcription factor activity, sequence-specific DNA binding GO:0001077 transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding GO:0003676 nucleic acid binding GO:0003677 DNA binding GO:0005515 protein binding GO:0042393 histone binding GO:0043565 sequence-specific DNA binding GO:0044212 transcription regulatory region DNA binding GO:0046872 metal ion binding
Biological Process: GO:0006325 chromatin organization GO:0006349 regulation of gene expression by genetic imprinting GO:0006351 transcription, DNA-templated GO:0006355 regulation of transcription, DNA-templated GO:0006366 transcription from RNA polymerase II promoter GO:0007049 cell cycle GO:0010628 positive regulation of gene expression GO:0016571 histone methylation GO:0043046 DNA methylation involved in gamete generation GO:0045893 positive regulation of transcription, DNA-templated GO:0045944 positive regulation of transcription from RNA polymerase II promoter GO:0051569 regulation of histone H3-K4 methylation
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Sequence and Links to Tools and Databases 
Common Gene Haplotype Alleles 
