ID:CNEP1_HUMAN DESCRIPTION: RecName: Full=CTD nuclear envelope phosphatase 1; EC=3.1.3.16; AltName: Full=Serine/threonine-protein phosphatase dullard; FUNCTION: Serine/threonine protein phosphatase forming with CNEP1R1 an active phosphatase complex that dephosphorylates and may activate LPIN1 and LPIN2. LPIN1 and LPIN2 are phosphatidate phosphatases that catalyze the conversion of phosphatidic acid to diacylglycerol and control the metabolism of fatty acids at differents levels. May indirectly modulate the lipid composition of nuclear and/or endoplasmic reticulum membranes and be required for proper nuclear membrane morphology and/or dynamics. May also indirectly regulate the production of lipid droplets and triacylglycerol. May antagonize BMP signaling. CATALYTIC ACTIVITY: A phosphoprotein + H(2)O = a protein + phosphate. BIOPHYSICOCHEMICAL PROPERTIES: Kinetic parameters: KM=18 mM for p-nitrophenylphosphate; pH dependence: Optimum pH is 5.5; SUBUNIT: Interacts with CNEP1R1; the complex dephosphorylates LPIN1 and LPIN2. INTERACTION: Q8N9A8:CNEP1R1; NbExp=4; IntAct=EBI-5323433, EBI-5323455; SUBCELLULAR LOCATION: Endoplasmic reticulum membrane; Single-pass membrane protein. Nucleus membrane; Single-pass membrane protein. TISSUE SPECIFICITY: Muscle specific with lower expression in other metabolic tissues. SIMILARITY: Belongs to the dullard family. SIMILARITY: Contains 1 FCP1 homology domain.
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
ModBase Predicted Comparative 3D Structure on O95476
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
US Server
Sequence and Links to Tools and Databases 
Common Gene Haplotype Alleles 
