Human Gene CTRL (ENST00000574481.6_7) from GENCODE V47lift37
  Description: chymotrypsin like (from RefSeq NM_001907.3)
Gencode Transcript: ENST00000574481.6_7
Gencode Gene: ENSG00000141086.18_10
Transcript (Including UTRs)
   Position: hg19 chr16:67,963,477-67,965,765 Size: 2,289 Total Exon Count: 7 Strand: -
Coding Region
   Position: hg19 chr16:67,963,837-67,965,755 Size: 1,919 Coding Exon Count: 7 

Page IndexSequence and LinksUniProtKB CommentsPrimersMalaCardsCTD
Gene AllelesRNA-Seq ExpressionMicroarray ExpressionRNA StructureProtein StructureOther Species
GO AnnotationsmRNA DescriptionsOther NamesModel InformationMethods
Data last updated at UCSC: 2024-08-22 23:36:26

-  Sequence and Links to Tools and Databases
 
Genomic Sequence (chr16:67,963,477-67,965,765)mRNA (may differ from genome)Protein (264 aa)
Gene SorterGenome BrowserOther Species FASTAVisiGeneGene interactionsTable Schema
AlphaFoldBioGPSEnsemblEntrez GeneExonPrimerGeneCards
HGNCMalacardsMGIOMIMPubMedUniProtKB
WikipediaBioGrid CRISPR DB

-  Comments and Description Text from UniProtKB
  ID: CTRL_HUMAN
DESCRIPTION: RecName: Full=Chymotrypsin-like protease CTRL-1; EC=3.4.21.-; Flags: Precursor;
SIMILARITY: Belongs to the peptidase S1 family.
SIMILARITY: Contains 1 peptidase S1 domain.

-  Primer design for this transcript
 

Primer3Plus can design qPCR Primers that straddle exon-exon-junctions, which amplify only cDNA, not genomic DNA.
Click here to load the transcript sequence and exon structure into Primer3Plus

Exonprimer can design one pair of Sanger sequencing primers around every exon, located in non-genic sequence.
Click here to open Exonprimer with this transcript

To design primers for a non-coding sequence, zoom to a region of interest and select from the drop-down menu: View > In External Tools > Primer3


-  MalaCards Disease Associations
  MalaCards Gene Search: CTRL
Diseases sorted by gene-association score: netherton syndrome (18), pericoronitis (15), severe acute respiratory syndrome (12), jmp syndrome (11), mouth disease (9), necrotizing ulcerative gingivitis (9)

-  Comparative Toxicogenomics Database (CTD)
  The following chemicals interact with this gene           more ... click here to view the complete list

+  Common Gene Haplotype Alleles
  Press "+" in the title bar above to open this section.

-  RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
  Highest median expression: 760.05 RPKM in Pancreas
Total median expression: 848.25 RPKM



View in GTEx track of Genome Browser    View at GTEx portal     View GTEx Body Map

+  Microarray Expression Data
  Press "+" in the title bar above to open this section.

-  mRNA Secondary Structure of 3' and 5' UTRs
 
RegionFold EnergyBasesEnergy/Base
Display As
3' UTR -105.10360-0.292 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Protein Domain and Structure Information
  InterPro Domains: Graphical view of domain structure
IPR009003 - Pept_cys/ser_Trypsin-like
IPR018114 - Peptidase_S1/S6_AS
IPR001254 - Peptidase_S1_S6
IPR001314 - Peptidase_S1A

Pfam Domains:
PF00089 - Trypsin
PF09342 - Domain of unknown function (DUF1986)
PF13365 - Trypsin-like peptidase domain

SCOP Domains:
50494 - Trypsin-like serine proteases

ModBase Predicted Comparative 3D Structure on P40313
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The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
MouseRatZebrafishD. melanogasterC. elegansS. cerevisiae
No orthologNo orthologNo orthologNo orthologNo orthologNo ortholog
Gene DetailsGene Details    
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 RGDEnsembl   
      
      

-  Gene Ontology (GO) Annotations with Structured Vocabulary
  Molecular Function:
GO:0004252 serine-type endopeptidase activity
GO:0008233 peptidase activity
GO:0008236 serine-type peptidase activity
GO:0016787 hydrolase activity

Biological Process:
GO:0006508 proteolysis
GO:0030163 protein catabolic process

Cellular Component:
GO:0005615 extracellular space


-  Descriptions from all associated GenBank mRNAs
  X71877 - H.sapiens mRNA for chymotrypsin-like protease CTRL-1.
AK090445 - Homo sapiens mRNA for FLJ00366 protein.
JD075819 - Sequence 56843 from Patent EP1572962.
AK223172 - Homo sapiens mRNA for chymotrypsin-like variant, clone: PNC01525.
BC039716 - Homo sapiens chymotrypsin-like, mRNA (cDNA clone IMAGE:5748224), partial cds.
BC063475 - Homo sapiens chymotrypsin-like, mRNA (cDNA clone MGC:70821 IMAGE:5223282), complete cds.
HQ448083 - Synthetic construct Homo sapiens clone IMAGE:100071463; CCSB012171_02 chymotrypsin-like (CTRL) gene, encodes complete protein.
KJ890999 - Synthetic construct Homo sapiens clone ccsbBroadEn_00393 CTRL gene, encodes complete protein.
CU687738 - Synthetic construct Homo sapiens gateway clone IMAGE:100021591 5' read CTRL mRNA.
JD156850 - Sequence 137874 from Patent EP1572962.

-  Other Names for This Gene
  Alternate Gene Symbols: CTRL1, CTRL_HUMAN, ENST00000574481.1, ENST00000574481.2, ENST00000574481.3, ENST00000574481.4, ENST00000574481.5, NM_001907, P40313, uc326def.1, uc326def.2
UCSC ID: ENST00000574481.6_7
RefSeq Accession: NM_001907.3
Protein: P40313 (aka CTRL_HUMAN)

-  Gene Model Information
  Click here for a detailed description of the fields of the table above.

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.