Human Gene CYSLTR1 (ENST00000373304.4_7) from GENCODE V47lift37
  Description: cysteinyl leukotriene receptor 1, transcript variant 3 (from RefSeq NM_006639.4)
Gencode Transcript: ENST00000373304.4_7
Gencode Gene: ENSG00000173198.6_9
Transcript (Including UTRs)
   Position: hg19 chrX:77,526,965-77,583,108 Size: 56,144 Total Exon Count: 3 Strand: -
Coding Region
   Position: hg19 chrX:77,528,230-77,529,243 Size: 1,014 Coding Exon Count: 1 

Page IndexSequence and LinksUniProtKB CommentsPrimersMalaCardsCTD
Gene AllelesRNA-Seq ExpressionMicroarray ExpressionRNA StructureProtein StructureOther Species
GO AnnotationsmRNA DescriptionsPathwaysOther NamesModel InformationMethods
Data last updated at UCSC: 2024-08-22 23:36:26

-  Sequence and Links to Tools and Databases
 
Genomic Sequence (chrX:77,526,965-77,583,108)mRNA (may differ from genome)Protein (337 aa)
Gene SorterGenome BrowserOther Species FASTAVisiGeneGene interactionsTable Schema
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HGNCMalacardsMGIOMIMPubMedReactome
UniProtKBWikipediaBioGrid CRISPR DB

-  Comments and Description Text from UniProtKB
  ID: CLTR1_HUMAN
DESCRIPTION: RecName: Full=Cysteinyl leukotriene receptor 1; Short=CysLTR1; AltName: Full=Cysteinyl leukotriene D4 receptor; Short=LTD4 receptor; AltName: Full=G-protein coupled receptor HG55; AltName: Full=HMTMF81;
FUNCTION: Receptor for cysteinyl leukotrienes mediating bronchoconstriction of individuals with and without asthma. Stimulation by LTD4 results in the contraction and proliferation of smooth muscle, edema, eosinophil migration and damage to the mucus layer in the lung. This response is mediated via a G-protein that activates a phosphatidylinositol-calcium second messenger system. The rank order of affinities for the leukotrienes is LTD4 >> LTE4 = LTC4 >> LTB4.
SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein.
TISSUE SPECIFICITY: Widely expressed, with highest levels in spleen and peripheral blood leukocytes. Lower expression in several tissues, such as lung (mostly in smooth muscle bundles and alveolar macrophages), placenta, small intestine, pancreas, colon and heart.
MISCELLANEOUS: Selective antagonists, such as montelukast (Singulair), zafirlukast (Accolate) and pranlukast (Onon), are used in the treatment of the asthma crisis.
SIMILARITY: Belongs to the G-protein coupled receptor 1 family.

-  Primer design for this transcript
 

Primer3Plus can design qPCR Primers that straddle exon-exon-junctions, which amplify only cDNA, not genomic DNA.
Click here to load the transcript sequence and exon structure into Primer3Plus

Exonprimer can design one pair of Sanger sequencing primers around every exon, located in non-genic sequence.
Click here to open Exonprimer with this transcript

To design primers for a non-coding sequence, zoom to a region of interest and select from the drop-down menu: View > In External Tools > Primer3


-  MalaCards Disease Associations
  MalaCards Gene Search: CYSLTR1
Diseases sorted by gene-association score: asthma (25), adenoid hypertrophy (15), rhinitis (14), sinusitis (9), bronchial disease (6), nose disease (5), nasal cavity disease (5), upper respiratory tract disease (5), respiratory system disease (2)

-  Comparative Toxicogenomics Database (CTD)
  The following chemicals interact with this gene           more ... click here to view the complete list

+  Common Gene Haplotype Alleles
  Press "+" in the title bar above to open this section.

-  RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
  Highest median expression: 4.86 RPKM in Esophagus - Muscularis
Total median expression: 26.48 RPKM



View in GTEx track of Genome Browser    View at GTEx portal     View GTEx Body Map

+  Microarray Expression Data
  Press "+" in the title bar above to open this section.

-  mRNA Secondary Structure of 3' and 5' UTRs
 
RegionFold EnergyBasesEnergy/Base
Display As
5' UTR -99.60421-0.237 Picture PostScript Text
3' UTR -261.001265-0.206 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Protein Domain and Structure Information
  InterPro Domains: Graphical view of domain structure
IPR000276 - 7TM_GPCR_Rhodpsn
IPR013310 - CLT1_recept
IPR004071 - Cyst_leuk_rcpt
IPR017452 - GPCR_Rhodpsn_supfam

Pfam Domains:
PF00001 - 7 transmembrane receptor (rhodopsin family)
PF10323 - Serpentine type 7TM GPCR chemoreceptor Srv
PF10324 - Serpentine type 7TM GPCR chemoreceptor Srw
PF10328 - Serpentine type 7TM GPCR chemoreceptor Srx

SCOP Domains:
81321 - Family A G protein-coupled receptor-like

ModBase Predicted Comparative 3D Structure on Q9Y271
FrontTopSide
The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
MouseRatZebrafishD. melanogasterC. elegansS. cerevisiae
No orthologNo orthologNo orthologNo orthologNo orthologNo ortholog
Gene DetailsGene Details    
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-  Gene Ontology (GO) Annotations with Structured Vocabulary
  Molecular Function:
GO:0004871 signal transducer activity
GO:0004930 G-protein coupled receptor activity
GO:0004974 leukotriene receptor activity
GO:0005515 protein binding
GO:0008528 G-protein coupled peptide receptor activity

Biological Process:
GO:0002437 inflammatory response to antigenic stimulus
GO:0003013 circulatory system process
GO:0006816 calcium ion transport
GO:0006935 chemotaxis
GO:0006952 defense response
GO:0007165 signal transduction
GO:0007166 cell surface receptor signaling pathway
GO:0007186 G-protein coupled receptor signaling pathway
GO:0007200 phospholipase C-activating G-protein coupled receptor signaling pathway
GO:0007204 positive regulation of cytosolic calcium ion concentration
GO:0007218 neuropeptide signaling pathway
GO:0007585 respiratory gaseous exchange
GO:0061737 leukotriene signaling pathway

Cellular Component:
GO:0005886 plasma membrane
GO:0005887 integral component of plasma membrane
GO:0016020 membrane
GO:0016021 integral component of membrane


-  Descriptions from all associated GenBank mRNAs
  DQ131803 - Homo sapiens cysteinyl leukotriene receptor 1 splice variant V mRNA, partial cds, alternatively spliced.
BC035750 - Homo sapiens cysteinyl leukotriene receptor 1, mRNA (cDNA clone MGC:46139 IMAGE:5750221), complete cds.
JD044352 - Sequence 25376 from Patent EP1572962.
AF119711 - Homo sapiens cysLT1 LTD4 receptor (CYSLT1) mRNA, complete cds.
AF133266 - Homo sapiens cysteinyl leukotriene receptor mRNA, complete cds.
DQ890947 - Synthetic construct clone IMAGE:100003577; FLH167868.01X; RZPDo839G0690D cysteinyl leukotriene receptor 1 (CYSLTR1) gene, encodes complete protein.
AK313643 - Homo sapiens cDNA, FLJ94219, Homo sapiens cysteinyl leukotriene receptor 1 (CYSLTR1), mRNA.
KJ904662 - Synthetic construct Homo sapiens clone ccsbBroadEn_14056 CYSLTR1-like gene, encodes complete protein.
EU176542 - Synthetic construct Homo sapiens clone IMAGE:100011359; FLH167867.01L; RZPDo839F08253D cysteinyl leukotriene receptor 1 (CYSLTR1) gene, encodes complete protein.
DQ131801 - Homo sapiens cysteinyl leukotriene receptor 1 splice variant III mRNA, partial cds, alternatively spliced.
DQ131800 - Homo sapiens cysteinyl leukotriene receptor 1 splice variant II mRNA, partial cds, alternatively spliced.
DQ131802 - Homo sapiens cysteinyl leukotriene receptor 1 splice variant IV mRNA, partial cds, alternatively spliced.
DQ131799 - Homo sapiens cysteinyl leukotriene receptor 1 splice variant I mRNA, partial cds, alternatively spliced.
JD091892 - Sequence 72916 from Patent EP1572962.
AK023929 - Homo sapiens cDNA FLJ13867 fis, clone THYRO1001262.
JD184661 - Sequence 165685 from Patent EP1572962.
JD041488 - Sequence 22512 from Patent EP1572962.
JD304546 - Sequence 285570 from Patent EP1572962.

-  Biochemical and Signaling Pathways
  BioCarta from NCI Cancer Genome Anatomy Project
h_eicosanoidPathway - Eicosanoid Metabolism

Reactome (by CSHL, EBI, and GO)

Protein Q9Y271 (Reactome details) participates in the following event(s):

R-HSA-391943 CysLT receptors can bind cysteinyl leukotrienes
R-HSA-749452 The Ligand:GPCR:Gq complex dissociates
R-HSA-749448 Liganded Gq-activating GPCRs bind inactive heterotrimeric Gq
R-HSA-379048 Liganded Gq/11-activating GPCRs act as GEFs for Gq/11
R-HSA-391906 Leukotriene receptors
R-HSA-416476 G alpha (q) signalling events
R-HSA-391903 Eicosanoid ligand-binding receptors
R-HSA-388396 GPCR downstream signalling
R-HSA-373076 Class A/1 (Rhodopsin-like receptors)
R-HSA-372790 Signaling by GPCR
R-HSA-500792 GPCR ligand binding
R-HSA-162582 Signal Transduction

-  Other Names for This Gene
  Alternate Gene Symbols: B2R954, CLTR1_HUMAN, CYSLT1, D3DTE4, ENST00000373304.1, ENST00000373304.2, ENST00000373304.3, NM_006639, Q5JS94, Q8IV19, Q9Y271, uc318kqy.1, uc318kqy.2
UCSC ID: ENST00000373304.4_7
RefSeq Accession: NM_006639.4
Protein: Q9Y271 (aka CLTR1_HUMAN or CLT1_HUMAN)

-  Gene Model Information
  Click here for a detailed description of the fields of the table above.

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.