Human Gene CYSLTR2 (ENST00000682523.1_2) from GENCODE V47lift37
  Description: cysteinyl leukotriene receptor 2, transcript variant VI (from RefSeq NM_020377.5)
Gencode Transcript: ENST00000682523.1_2
Gencode Gene: ENSG00000152207.8_6
Transcript (Including UTRs)
   Position: hg19 chr13:49,228,065-49,285,362 Size: 57,298 Total Exon Count: 5 Strand: +
Coding Region
   Position: hg19 chr13:49,280,954-49,281,994 Size: 1,041 Coding Exon Count: 1 

Page IndexSequence and LinksUniProtKB CommentsPrimersMalaCardsCTD
Gene AllelesRNA StructureProtein StructureOther SpeciesGO AnnotationsmRNA Descriptions
PathwaysOther NamesModel InformationMethods
Data last updated at UCSC: 2024-08-22 23:36:26

-  Sequence and Links to Tools and Databases
 
Genomic Sequence (chr13:49,228,065-49,285,362)mRNA (may differ from genome)Protein (346 aa)
Gene SorterGenome BrowserOther Species FASTAVisiGeneGene interactionsTable Schema
AlphaFoldBioGPSEnsemblEntrez GeneExonPrimerGeneCards
HGNCMalacardsMGIOMIMPubMedReactome
UniProtKBWikipediaBioGrid CRISPR DB

-  Comments and Description Text from UniProtKB
  ID: CLTR2_HUMAN
DESCRIPTION: RecName: Full=Cysteinyl leukotriene receptor 2; Short=CysLTR2; AltName: Full=G-protein coupled receptor GPCR21; Short=hGPCR21; AltName: Full=G-protein coupled receptor HG57; AltName: Full=HPN321;
FUNCTION: Receptor for cysteinyl leukotrienes. The response is mediated via a G-protein that activates a phosphatidylinositol- calcium second messenger system. Stimulation by BAY u9773, a partial agonist, induces specific contractions of pulmonary veins and might also have an indirect role in the relaxation of the pulmonary vascular endothelium. The rank order of affinities for the leukotrienes is LTC4 = LTD4 >> LTE4.
SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein.
TISSUE SPECIFICITY: Widely expressed, with highest levels in the heart, placenta, spleen, peripheral blood leukocytes and adrenal gland. In lung, expressed in the interstitial macrophages, and slightly in smooth muscle cells.
SIMILARITY: Belongs to the G-protein coupled receptor 1 family.

-  Primer design for this transcript
 

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Click here to load the transcript sequence and exon structure into Primer3Plus

Exonprimer can design one pair of Sanger sequencing primers around every exon, located in non-genic sequence.
Click here to open Exonprimer with this transcript

To design primers for a non-coding sequence, zoom to a region of interest and select from the drop-down menu: View > In External Tools > Primer3


-  MalaCards Disease Associations
  MalaCards Gene Search: CYSLTR2
Diseases sorted by gene-association score: uveal melanoma* (181), adenoid hypertrophy (22), asthma (11)
* = Manually curated disease association

-  Comparative Toxicogenomics Database (CTD)
  The following chemicals interact with this gene           more ... click here to view the complete list

+  Common Gene Haplotype Alleles
  Press "+" in the title bar above to open this section.

-  mRNA Secondary Structure of 3' and 5' UTRs
 
RegionFold EnergyBasesEnergy/Base
Display As
5' UTR -87.50354-0.247 Picture PostScript Text
3' UTR -893.903368-0.265 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Protein Domain and Structure Information
  InterPro Domains: Graphical view of domain structure
IPR000276 - 7TM_GPCR_Rhodpsn
IPR013311 - CLT2_recept
IPR004071 - Cyst_leuk_rcpt
IPR017452 - GPCR_Rhodpsn_supfam

Pfam Domains:
PF00001 - 7 transmembrane receptor (rhodopsin family)
PF05296 - Taste receptor protein (TAS2R)

SCOP Domains:
81321 - Family A G protein-coupled receptor-like

ModBase Predicted Comparative 3D Structure on Q9NS75
FrontTopSide
The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
MouseRatZebrafishD. melanogasterC. elegansS. cerevisiae
No orthologNo orthologNo orthologNo orthologNo orthologNo ortholog
Gene DetailsGene Details    
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-  Gene Ontology (GO) Annotations with Structured Vocabulary
  Molecular Function:
GO:0001631 cysteinyl leukotriene receptor activity
GO:0004871 signal transducer activity
GO:0004930 G-protein coupled receptor activity
GO:0004974 leukotriene receptor activity
GO:0005515 protein binding
GO:0008528 G-protein coupled peptide receptor activity

Biological Process:
GO:0006955 immune response
GO:0007165 signal transduction
GO:0007186 G-protein coupled receptor signaling pathway
GO:0007200 phospholipase C-activating G-protein coupled receptor signaling pathway
GO:0007218 neuropeptide signaling pathway
GO:0010942 positive regulation of cell death
GO:0045766 positive regulation of angiogenesis
GO:0061737 leukotriene signaling pathway
GO:0070374 positive regulation of ERK1 and ERK2 cascade

Cellular Component:
GO:0005575 cellular_component
GO:0005886 plasma membrane
GO:0005887 integral component of plasma membrane
GO:0016020 membrane
GO:0016021 integral component of membrane


-  Descriptions from all associated GenBank mRNAs
  AB038269 - Homo sapiens mRNA for cysteinyl leukotriene CysLT2 receptor, complete cds; cDNA: PSEC0146 from clone PLACE1006979.
BC069160 - Homo sapiens cysteinyl leukotriene receptor 2, mRNA (cDNA clone MGC:95345 IMAGE:7216884), complete cds.
JD341109 - Sequence 322133 from Patent EP1572962.
AK291739 - Homo sapiens cDNA FLJ78284 complete cds, highly similar to Homo sapiens cysteinyl leukotriene receptor 2 (CYSLTR2), mRNA.
EF141523 - Homo sapiens cysteinyl leukotriene receptor 2 splice variant I (CYSLTR2) mRNA, partial cds, alternatively spliced.
EF141524 - Homo sapiens cysteinyl leukotriene receptor 2 splice variant II (CYSLTR2) mRNA, partial cds, alternatively spliced.
EF141530 - Homo sapiens cysteinyl leukotriene receptor 2 splice variant VIII (CYSLTR2) mRNA, partial cds, alternatively spliced.
EF141525 - Homo sapiens cysteinyl leukotriene receptor 2 splice variant III (CYSLTR2) mRNA, partial cds, alternatively spliced.
EF141526 - Homo sapiens cysteinyl leukotriene receptor 2 splice variant IV (CYSLTR2) mRNA, partial cds, alternatively spliced.
EF141527 - Homo sapiens cysteinyl leukotriene receptor 2 splice variant V (CYSLTR2) mRNA, partial cds, alternatively spliced.
EF141528 - Homo sapiens cysteinyl leukotriene receptor 2 splice variant VI (CYSLTR2) mRNA, partial cds, alternatively spliced.
EF141529 - Homo sapiens cysteinyl leukotriene receptor 2 splice variant VII (CYSLTR2) mRNA, partial cds, alternatively spliced.
AY853711 - Homo sapiens cysteinyl leukotriene receptor 2 (CYSLTR2) mRNA, complete cds.
AB041947 - Homo sapiens KPG_011 mRNA for G-protein coupled receptor protein, complete cds.
BC096832 - Homo sapiens cysteinyl leukotriene receptor 2, mRNA (cDNA clone MGC:111709 IMAGE:6971946), complete cds.
AB590816 - Synthetic construct DNA, clone: pFN21AE1828, Homo sapiens CYSLTR2 gene for cysteinyl leukotriene receptor 2, without stop codon, in Flexi system.
KJ899304 - Synthetic construct Homo sapiens clone ccsbBroadEn_08698 CYSLTR2 gene, encodes complete protein.
JD266095 - Sequence 247119 from Patent EP1572962.
JD066474 - Sequence 47498 from Patent EP1572962.
JD369429 - Sequence 350453 from Patent EP1572962.
JD302093 - Sequence 283117 from Patent EP1572962.
JD149538 - Sequence 130562 from Patent EP1572962.
JD518206 - Sequence 499230 from Patent EP1572962.
JD137798 - Sequence 118822 from Patent EP1572962.
JD197132 - Sequence 178156 from Patent EP1572962.
JD309219 - Sequence 290243 from Patent EP1572962.
JD183499 - Sequence 164523 from Patent EP1572962.
JD051679 - Sequence 32703 from Patent EP1572962.
JD375612 - Sequence 356636 from Patent EP1572962.
JD473323 - Sequence 454347 from Patent EP1572962.
JD113903 - Sequence 94927 from Patent EP1572962.
JD109189 - Sequence 90213 from Patent EP1572962.
JD470075 - Sequence 451099 from Patent EP1572962.
JD434031 - Sequence 415055 from Patent EP1572962.
JD341226 - Sequence 322250 from Patent EP1572962.
JD168267 - Sequence 149291 from Patent EP1572962.
JD348848 - Sequence 329872 from Patent EP1572962.
JD431921 - Sequence 412945 from Patent EP1572962.
JD324142 - Sequence 305166 from Patent EP1572962.
JD348761 - Sequence 329785 from Patent EP1572962.
JD347386 - Sequence 328410 from Patent EP1572962.
JD232893 - Sequence 213917 from Patent EP1572962.
JD168503 - Sequence 149527 from Patent EP1572962.
JD311068 - Sequence 292092 from Patent EP1572962.
JD121512 - Sequence 102536 from Patent EP1572962.
JD227425 - Sequence 208449 from Patent EP1572962.
JD403780 - Sequence 384804 from Patent EP1572962.
JD053763 - Sequence 34787 from Patent EP1572962.
JD325568 - Sequence 306592 from Patent EP1572962.
JD331382 - Sequence 312406 from Patent EP1572962.
JD263639 - Sequence 244663 from Patent EP1572962.

-  Biochemical and Signaling Pathways
  BioCarta from NCI Cancer Genome Anatomy Project
h_eicosanoidPathway - Eicosanoid Metabolism

Reactome (by CSHL, EBI, and GO)

Protein Q9NS75 (Reactome details) participates in the following event(s):

R-HSA-391943 CysLT receptors can bind cysteinyl leukotrienes
R-HSA-749452 The Ligand:GPCR:Gq complex dissociates
R-HSA-749448 Liganded Gq-activating GPCRs bind inactive heterotrimeric Gq
R-HSA-379048 Liganded Gq/11-activating GPCRs act as GEFs for Gq/11
R-HSA-391906 Leukotriene receptors
R-HSA-416476 G alpha (q) signalling events
R-HSA-391903 Eicosanoid ligand-binding receptors
R-HSA-388396 GPCR downstream signalling
R-HSA-373076 Class A/1 (Rhodopsin-like receptors)
R-HSA-372790 Signaling by GPCR
R-HSA-500792 GPCR ligand binding
R-HSA-162582 Signal Transduction

-  Other Names for This Gene
  Alternate Gene Symbols: CLTR2_HUMAN, CYSLT2, CYSLT2R, NM_020377, PSEC0146, Q9HCQ2, Q9NS75, uc330kav.1, uc330kav.2
UCSC ID: ENST00000682523.1_2
RefSeq Accession: NM_001308476.3
Protein: Q9NS75 (aka CLTR2_HUMAN or CLT2_HUMAN)

-  Gene Model Information
  Click here for a detailed description of the fields of the table above.

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.