Human Gene CYTH1 (ENST00000446868.8_10) from GENCODE V47lift37

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Description: cytohesin 1, transcript variant 1 (from RefSeq NM_004762.6)
Gencode Transcript: ENST00000446868.8_10
Gencode Gene: ENSG00000108669.18_20
Transcript (Including UTRs)
Position: hg19 chr17:76,670,130-76,778,355 Size: 108,226 Total Exon Count: 14 Strand: -
Coding Region
Position: hg19 chr17:76,672,173-76,778,305 Size: 106,133 Coding Exon Count: 14

Page Index	Sequence and Links	UniProtKB Comments	Primers	MalaCards	CTD
Gene Alleles	RNA-Seq Expression	Microarray Expression	RNA Structure	Protein Structure	Other Species
GO Annotations	mRNA Descriptions	Pathways	Other Names	Model Information	Methods

Data last updated at UCSC: 2024-08-22 23:36:26

Sequence and Links to Tools and Databases

Genomic Sequence (chr17:76,670,130-76,778,355)			mRNA (may differ from genome)		Protein (398 aa)
Gene Sorter	Genome Browser	Other Species FASTA	VisiGene	Gene interactions	Table Schema
AlphaFold	BioGPS	Ensembl	Entrez Gene	ExonPrimer	GeneCards
HGNC	Malacards	MGI	OMIM	PubMed	Reactome
UniProtKB	Wikipedia	BioGrid CRISPR DB

Comments and Description Text from UniProtKB


	ID: CYH1_HUMAN DESCRIPTION: RecName: Full=Cytohesin-1; AltName: Full=PH, SEC7 and coiled-coil domain-containing protein 1; AltName: Full=SEC7 homolog B2-1; FUNCTION: Promotes guanine-nucleotide exchange on ARF1 and ARF5. Promotes the activation of ARF through replacement of GDP with GTP. SUBUNIT: Interacts with TRIM23 and CYTIP. INTERACTION: O60759:CYTIP; NbExp=2; IntAct=EBI-997830, EBI-997814; SUBCELLULAR LOCATION: Cell membrane. TISSUE SPECIFICITY: Ubiquitous. SIMILARITY: Contains 1 PH domain. SIMILARITY: Contains 1 SEC7 domain.

Primer design for this transcript

Primer3Plus can design qPCR Primers that straddle exon-exon-junctions, which amplify only cDNA, not genomic DNA.
Click here to load the transcript sequence and exon structure into Primer3Plus

Exonprimer can design one pair of Sanger sequencing primers around every exon, located in non-genic sequence.
Click here to open Exonprimer with this transcript

To design primers for a non-coding sequence, zoom to a region of interest and select from the drop-down menu: View > In External Tools > Primer3

MalaCards Disease Associations


	MalaCards Gene Search: CYTH1 Diseases sorted by gene-association score: heterotopia, periventricular (1)

Comparative Toxicogenomics Database (CTD)


	The following chemicals interact with this gene D019327 Copper Sulfate D019833 Genistein D013749 Tetrachlorodibenzodioxin D015032 Zinc D015124 8-Bromo Cyclic Adenosine Monophosphate D000082 Acetaminophen D016604 Aflatoxin B1 D000643 Ammonium Chloride D001374 Azacitidine D001554 Benzene more ... click here to view the complete list

Common Gene Haplotype Alleles


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RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)


	Highest median expression: 66.14 RPKM in Cells - EBV-transformed lymphocytes Total median expression: 881.41 RPKM View in GTEx track of Genome Browser View at GTEx portal View GTEx Body Map

Microarray Expression Data


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mRNA Secondary Structure of 3' and 5' UTRs

Region	Fold Energy	Bases	Energy/Base	Display As
5' UTR	-31.10	50	-0.622	Picture	PostScript	Text
3' UTR	-857.50	2043	-0.420	Picture	PostScript	Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

Protein Domain and Structure Information

InterPro Domains: Graphical view of domain structure
IPR011993 - PH_like_dom
IPR001849 - Pleckstrin_homology
IPR000904 - Sec7
IPR023394 - SEC7_alpha_orthog

Pfam Domains:
PF00169 - PH domain
PF01369 - Sec7 domain

SCOP Domains:
48425 - Sec7 domain
103657 - BAR/IMD domain-like
50729 - PH domain-like
57586 - TNF receptor-like

Protein Data Bank (PDB) 3-D Structure
MuPIT help

1BC9 - NMR MuPIT

ModBase Predicted Comparative 3D Structure on Q15438


Front	Top	Side

The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

Orthologous Genes in Other Species

Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.

Mouse	Rat	Zebrafish	D. melanogaster	C. elegans	S. cerevisiae
No ortholog	No ortholog	No ortholog	No ortholog	No ortholog	No ortholog
Gene Details	Gene Details
Gene Sorter	Gene Sorter
	RGD

Gene Ontology (GO) Annotations with Structured Vocabulary


	Molecular Function: GO:0005085 guanyl-nucleotide exchange factor activity GO:0005086 ARF guanyl-nucleotide exchange factor activity GO:0005515 protein binding GO:0008289 lipid binding Biological Process: GO:0016192 vesicle-mediated transport GO:0030155 regulation of cell adhesion GO:0032012 regulation of ARF protein signal transduction GO:0090162 establishment of epithelial cell polarity Cellular Component: GO:0000139 Golgi membrane GO:0005737 cytoplasm GO:0005829 cytosol GO:0005886 plasma membrane GO:0005912 adherens junction GO:0005923 bicellular tight junction GO:0016020 membrane GO:0030054 cell junction GO:0031234 extrinsic component of cytoplasmic side of plasma membrane

Descriptions from all associated GenBank mRNAs


	BC038385 - Homo sapiens cytohesin 1, mRNA (cDNA clone MGC:21351 IMAGE:4755203), complete cds. M85169 - Human homologue of yeast sec7 mRNA, complete cds. BC050452 - Homo sapiens cytohesin 1, mRNA (cDNA clone MGC:54241 IMAGE:6043039), complete cds. AK293894 - Homo sapiens cDNA FLJ54415 complete cds, highly similar to Cytohesin-1. AK316277 - Homo sapiens cDNA, FLJ79176 complete cds, highly similar to Cytohesin-1. AK316075 - Homo sapiens cDNA, FLJ78974 complete cds, highly similar to Cytohesin-1. AK307917 - Homo sapiens cDNA, FLJ97865. AK296914 - Homo sapiens cDNA FLJ59923 complete cds, highly similar to Cytohesin-1. EU832306 - Synthetic construct Homo sapiens clone HAIB:100067335; DKFZo008C0927 pleckstrin homology, Sec7 and coiled-coil domains 1(cytohesin 1) protein (PSCD1) gene, encodes complete protein. EU832390 - Synthetic construct Homo sapiens clone HAIB:100067419; DKFZo004C0928 pleckstrin homology, Sec7 and coiled-coil domains 1(cytohesin 1) protein (PSCD1) gene, encodes complete protein. AB590939 - Synthetic construct DNA, clone: pFN21AE1139, Homo sapiens CYTH1 gene for cytohesin 1, without stop codon, in Flexi system. AK123894 - Homo sapiens cDNA FLJ41900 fis, clone OCBBF3000483. AF054997 - Homo sapiens clone 23796 mRNA sequence. AK091369 - Homo sapiens cDNA FLJ34050 fis, clone FCBBF3000115. AX746941 - Sequence 466 from Patent EP1308459. AL832791 - Homo sapiens mRNA; cDNA DKFZp667F0323 (from clone DKFZp667F0323). JD438334 - Sequence 419358 from Patent EP1572962. JD527186 - Sequence 508210 from Patent EP1572962. JD062300 - Sequence 43324 from Patent EP1572962. JD280601 - Sequence 261625 from Patent EP1572962. JD051648 - Sequence 32672 from Patent EP1572962. JD347320 - Sequence 328344 from Patent EP1572962. JD535883 - Sequence 516907 from Patent EP1572962. JD372726 - Sequence 353750 from Patent EP1572962. JD191221 - Sequence 172245 from Patent EP1572962. JD384988 - Sequence 366012 from Patent EP1572962. JD524865 - Sequence 505889 from Patent EP1572962. JD129895 - Sequence 110919 from Patent EP1572962. JD100346 - Sequence 81370 from Patent EP1572962. JD462133 - Sequence 443157 from Patent EP1572962. JD392648 - Sequence 373672 from Patent EP1572962. JD253647 - Sequence 234671 from Patent EP1572962. JD395824 - Sequence 376848 from Patent EP1572962. JD261002 - Sequence 242026 from Patent EP1572962. JD360064 - Sequence 341088 from Patent EP1572962. JD334083 - Sequence 315107 from Patent EP1572962. JD303996 - Sequence 285020 from Patent EP1572962. JD205776 - Sequence 186800 from Patent EP1572962. JD251442 - Sequence 232466 from Patent EP1572962. JD203535 - Sequence 184559 from Patent EP1572962. JD177949 - Sequence 158973 from Patent EP1572962. JD464948 - Sequence 445972 from Patent EP1572962. JD338204 - Sequence 319228 from Patent EP1572962. JD462455 - Sequence 443479 from Patent EP1572962. JD108588 - Sequence 89612 from Patent EP1572962. JD164043 - Sequence 145067 from Patent EP1572962. JD078069 - Sequence 59093 from Patent EP1572962. JD562919 - Sequence 543943 from Patent EP1572962. JD198709 - Sequence 179733 from Patent EP1572962. JD423277 - Sequence 404301 from Patent EP1572962. JD170809 - Sequence 151833 from Patent EP1572962. AK311535 - Homo sapiens cDNA, FLJ18577.

Biochemical and Signaling Pathways


	BioCarta from NCI Cancer Genome Anatomy Project h_arapPathway - ADP-Ribosylation Factor Reactome (by CSHL, EBI, and GO) Protein Q15438 (Reactome details) participates in the following event(s): R-HSA-8847880 CYTH proteins bind ARF1:GTP R-HSA-8847883 CYTH proteins stimulate ARF1 GTPase activity R-HSA-6811438 Intra-Golgi traffic R-HSA-6811442 Intra-Golgi and retrograde Golgi-to-ER traffic R-HSA-199991 Membrane Trafficking R-HSA-5653656 Vesicle-mediated transport

Other Names for This Gene


	Alternate Gene Symbols: A6NFW7, B7Z1T4, CYH1_HUMAN, CYTH1 , D17S811E, ENST00000446868.1, ENST00000446868.2, ENST00000446868.3, ENST00000446868.4, ENST00000446868.5, ENST00000446868.6, ENST00000446868.7, NM_004762, PSCD1, Q15438, Q9P123, Q9P124, uc320one.1, uc320one.2 UCSC ID: ENST00000446868.8_10 RefSeq Accession: NM_004762.6 Protein: Q15438 (aka CYH1_HUMAN)

Gene Model Information


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Methods, Credits, and Use Restrictions


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