ID:DCTN2_HUMAN DESCRIPTION: RecName: Full=Dynactin subunit 2; AltName: Full=50 kDa dynein-associated polypeptide; AltName: Full=Dynactin complex 50 kDa subunit; Short=DCTN-50; AltName: Full=p50 dynamitin; FUNCTION: Modulates cytoplasmic dynein binding to an organelle, and plays a role in prometaphase chromosome alignment and spindle organization during mitosis. Involved in anchoring microtubules to centrosomes. May play a role in synapse formation during brain development. SUBUNIT: Subunit of dynactin, a multiprotein complex associated with dynein. Interacts with BICD2 and CEP135 (By similarity). Interacts with MAPRE1. Interacts with ECM29. INTERACTION: Q9NRI5:DISC1; NbExp=3; IntAct=EBI-715074, EBI-529989; SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton, centrosome. Membrane; Peripheral membrane protein. SIMILARITY: Belongs to the dynactin subunit 2 family. SEQUENCE CAUTION: Sequence=AAO34395.1; Type=Frameshift; Positions=381;
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
ModBase Predicted Comparative 3D Structure on Q13561
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
Biological Process: GO:0000086 G2/M transition of mitotic cell cycle GO:0000278 mitotic cell cycle GO:0006888 ER to Golgi vesicle-mediated transport GO:0007017 microtubule-based process GO:0007052 mitotic spindle organization GO:0008283 cell proliferation GO:0010389 regulation of G2/M transition of mitotic cell cycle GO:0019886 antigen processing and presentation of exogenous peptide antigen via MHC class II GO:0032402 melanosome transport GO:0071539 protein localization to centrosome GO:0097711 ciliary basal body docking
BC064331 - Homo sapiens cDNA clone IMAGE:5797909, **** WARNING: chimeric clone ****. AK096242 - Homo sapiens cDNA FLJ38923 fis, clone NT2NE2011823, highly similar to Dynactin subunit 2. BC009468 - Homo sapiens dynactin 2 (p50), mRNA (cDNA clone MGC:16056 IMAGE:3613836), complete cds. FJ224315 - Homo sapiens epididymis secretory protein Li 77 (HEL-S-77) mRNA, complete cds. U50733 - Homo sapiens dynamitin mRNA, complete cds. BC014083 - Homo sapiens dynactin 2 (p50), mRNA (cDNA clone MGC:20331 IMAGE:4303142), complete cds. AK098794 - Homo sapiens cDNA FLJ25928 fis, clone CBR05333, highly similar to DYNACTIN, 50 KDA ISOFORM. BC000718 - Homo sapiens dynactin 2 (p50), mRNA (cDNA clone MGC:1336 IMAGE:3504109), complete cds. GQ891494 - Homo sapiens clone HEL-S-215 epididymis secretory sperm binding protein mRNA, complete cds. AK055682 - Homo sapiens cDNA FLJ31120 fis, clone IMR322000730, highly similar to Dynactin subunit 2. AK222693 - Homo sapiens mRNA for dynactin 2 variant, clone: CBR05685. AK292364 - Homo sapiens cDNA FLJ77785 complete cds. AK314705 - Homo sapiens cDNA, FLJ95559, Homo sapiens dynactin 2 (p50) (DCTN2), mRNA. HQ447201 - Synthetic construct Homo sapiens clone IMAGE:100070498; CCSB003453_01 dynactin 2 (p50) (DCTN2) gene, encodes complete protein. KJ902126 - Synthetic construct Homo sapiens clone ccsbBroadEn_11520 DCTN2 gene, encodes complete protein. AB590544 - Synthetic construct DNA, clone: pFN21AE1882, Homo sapiens DCTN2 gene for dynactin 2, without stop codon, in Flexi system. AY189155 - Homo sapiens p50 dynamitin mRNA, complete cds. CU674356 - Synthetic construct Homo sapiens gateway clone IMAGE:100018226 5' read DCTN2 mRNA. JD295925 - Sequence 276949 from Patent EP1572962. JD324665 - Sequence 305689 from Patent EP1572962. JD307519 - Sequence 288543 from Patent EP1572962. JD551860 - Sequence 532884 from Patent EP1572962. JD175004 - Sequence 156028 from Patent EP1572962.
Biochemical and Signaling Pathways
Reactome (by CSHL, EBI, and GO)
Protein Q13561 (Reactome details) participates in the following event(s):
R-HSA-380272 Plk1-mediated phosphorylation of Nlp R-HSA-380283 Recruitment of additional gamma tubulin/ gamma TuRC to the centrosome R-HSA-380294 Loss of C-Nap-1 from centrosomes R-HSA-380311 Recruitment of Plk1 to centrosomes R-HSA-380455 Recruitment of CDK11p58 to the centrosomes R-HSA-380303 Dissociation of Phospho-Nlp from the centrosome R-HSA-5626220 C2CD3 binds the mother centriole R-HSA-380508 Translocation of NuMA to the centrosomes R-HSA-2574845 AJUBA binds centrosome-associated AURKA R-HSA-8853405 TPX2 binds AURKA at centrosomes R-HSA-3000319 BORA binds PLK1 and AURKA R-HSA-2574840 AJUBA facilitates AURKA autophosphorylation R-HSA-3000310 AURKA phosphorylates PLK1 R-HSA-5626223 C2CD3 and OFD1 recruit 5 distal appendage proteins to the centriole R-HSA-5626681 Recruitment of transition zone proteins R-HSA-5626227 CP110 and CEP97 dissociate from the centriole R-HSA-380316 Association of NuMA with microtubules R-HSA-8853419 TPX2 promotes AURKA autophosphorylation R-HSA-5626228 The distal appendage proteins recruit TTBK2 R-HSA-5638009 CEP164 recruits RAB3IP-carrying Golgi-derived vesicles to the basal body R-HSA-5626699 MARK4 binds ODF2 in the centriole R-HSA-5617816 RAB3IP stimulates nucleotide exchange on RAB8A R-HSA-6809003 ERGIC-to-Golgi vesicles bind dynein:dynactin R-HSA-6809006 Vesicle is tethered through binding GOLGA2:GORASP1, GOLGB1 and the COG complex R-HSA-8849350 RAB6:GTP displaces PAFAH1B1 from dynein:dynactin complex R-HSA-380259 Loss of Nlp from mitotic centrosomes R-HSA-380270 Recruitment of mitotic centrosome proteins and complexes R-HSA-380284 Loss of proteins required for interphase microtubule organization from the centrosome R-HSA-5620912 Anchoring of the basal body to the plasma membrane R-HSA-380320 Recruitment of NuMA to mitotic centrosomes R-HSA-2565942 Regulation of PLK1 Activity at G2/M Transition R-HSA-8854518 AURKA Activation by TPX2 R-HSA-380287 Centrosome maturation R-HSA-5617833 Cilium Assembly R-HSA-68877 Mitotic Prometaphase R-HSA-69275 G2/M Transition R-HSA-1852241 Organelle biogenesis and maintenance R-HSA-68886 M Phase R-HSA-453274 Mitotic G2-G2/M phases R-HSA-69278 Cell Cycle (Mitotic) R-HSA-2132295 MHC class II antigen presentation R-HSA-6807878 COPI-mediated anterograde transport R-HSA-6811436 COPI-independent Golgi-to-ER retrograde traffic R-HSA-1640170 Cell Cycle R-HSA-1280218 Adaptive Immune System R-HSA-199977 ER to Golgi Anterograde Transport R-HSA-8856688 Golgi-to-ER retrograde transport R-HSA-168256 Immune System R-HSA-199991 Membrane Trafficking R-HSA-948021 Transport to the Golgi and subsequent modification R-HSA-6811442 Intra-Golgi and retrograde Golgi-to-ER traffic R-HSA-5653656 Vesicle-mediated transport R-HSA-446203 Asparagine N-linked glycosylation R-HSA-597592 Post-translational protein modification R-HSA-392499 Metabolism of proteins
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Sequence and Links to Tools and Databases 
Common Gene Haplotype Alleles 
