Human Gene DDX18 (ENST00000263239.7_4) from GENCODE V47lift37

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Description: DEAD-box helicase 18 (from RefSeq NM_006773.4)
Gencode Transcript: ENST00000263239.7_4
Gencode Gene: ENSG00000088205.13_7
Transcript (Including UTRs)
Position: hg19 chr2:118,572,267-118,589,953 Size: 17,687 Total Exon Count: 14 Strand: +
Coding Region
Position: hg19 chr2:118,572,354-118,588,300 Size: 15,947 Coding Exon Count: 14

Page Index	Sequence and Links	UniProtKB Comments	Primers	CTD	Gene Alleles
RNA-Seq Expression	Microarray Expression	RNA Structure	Protein Structure	Other Species	GO Annotations
mRNA Descriptions	Other Names	Model Information	Methods

Data last updated at UCSC: 2024-08-22 23:36:26

Sequence and Links to Tools and Databases

Genomic Sequence (chr2:118,572,267-118,589,953)			mRNA (may differ from genome)		Protein (670 aa)
Gene Sorter	Genome Browser	Other Species FASTA	VisiGene	Gene interactions	Table Schema
AlphaFold	BioGPS	Ensembl	Entrez Gene	ExonPrimer	GeneCards
HGNC	MGI	OMIM	PubMed	UniProtKB	BioGrid CRISPR DB

Comments and Description Text from UniProtKB


	ID: DDX18_HUMAN DESCRIPTION: RecName: Full=ATP-dependent RNA helicase DDX18; EC=3.6.4.13; AltName: Full=DEAD box protein 18; AltName: Full=Myc-regulated DEAD box protein; Short=MrDb; FUNCTION: Probable RNA-dependent helicase. CATALYTIC ACTIVITY: ATP + H(2)O = ADP + phosphate. SUBUNIT: Interacts with NOL8; the interaction is RNA-dependent. SUBCELLULAR LOCATION: Nucleus, nucleolus. SIMILARITY: Belongs to the DEAD box helicase family. DDX18/HAS1 subfamily. SIMILARITY: Contains 1 helicase ATP-binding domain. SIMILARITY: Contains 1 helicase C-terminal domain. SEQUENCE CAUTION: Sequence=CAA67295.1; Type=Erroneous initiation;

Primer design for this transcript

Primer3Plus can design qPCR Primers that straddle exon-exon-junctions, which amplify only cDNA, not genomic DNA.
Click here to load the transcript sequence and exon structure into Primer3Plus

Exonprimer can design one pair of Sanger sequencing primers around every exon, located in non-genic sequence.
Click here to open Exonprimer with this transcript

To design primers for a non-coding sequence, zoom to a region of interest and select from the drop-down menu: View > In External Tools > Primer3

Comparative Toxicogenomics Database (CTD)


	The following chemicals interact with this gene D000082 Acetaminophen C016403 2,4-dinitrotoluene C023514 2,6-dinitrotoluene C035207 4-amino-2,6-dinitrotoluene D001241 Aspirin D002737 Chloroprene D016572 Cyclosporine D003993 Dibutyl Phthalate D004041 Dietary Fats D004178 Diquat more ... click here to view the complete list

Common Gene Haplotype Alleles


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RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)


	Highest median expression: 42.65 RPKM in Cells - EBV-transformed lymphocytes Total median expression: 738.35 RPKM View in GTEx track of Genome Browser View at GTEx portal View GTEx Body Map

Microarray Expression Data


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mRNA Secondary Structure of 3' and 5' UTRs

Region	Fold Energy	Bases	Energy/Base	Display As
5' UTR	-22.30	87	-0.256	Picture	PostScript	Text
3' UTR	-378.70	1653	-0.229	Picture	PostScript	Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

Protein Domain and Structure Information

InterPro Domains: Graphical view of domain structure
IPR011545 - DNA/RNA_helicase_DEAD/DEAH_N
IPR025313 - DUF4217
IPR014001 - Helicase_ATP-bd
IPR001650 - Helicase_C
IPR000629 - RNA-helicase_DEAD-box_CS
IPR014014 - RNA_helicase_DEAD_Q_motif

Pfam Domains:
PF00270 - DEAD/DEAH box helicase
PF00271 - Helicase conserved C-terminal domain
PF13959 - Domain of unknown function (DUF4217)

SCOP Domains:
52540 - P-loop containing nucleoside triphosphate hydrolases

Protein Data Bank (PDB) 3-D Structure
MuPIT help

3LY5 - X-ray MuPIT

ModBase Predicted Comparative 3D Structure on Q9NVP1


Front	Top	Side

The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

Orthologous Genes in Other Species

Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.

Mouse	Rat	Zebrafish	D. melanogaster	C. elegans	S. cerevisiae
No ortholog	No ortholog	No ortholog	No ortholog	Genome Browser	Genome Browser
Gene Details	Gene Details		Gene Details	Gene Details	Gene Details
Gene Sorter	Gene Sorter		Gene Sorter	Gene Sorter	Gene Sorter
	RGD	Ensembl		WormBase	SGD
				Protein Sequence	Protein Sequence
				Alignment	Alignment

Gene Ontology (GO) Annotations with Structured Vocabulary


	Molecular Function: GO:0000166 nucleotide binding GO:0003676 nucleic acid binding GO:0003723 RNA binding GO:0004004 ATP-dependent RNA helicase activity GO:0004386 helicase activity GO:0005515 protein binding GO:0005524 ATP binding GO:0016787 hydrolase activity Biological Process: GO:0010501 RNA secondary structure unwinding GO:0071392 cellular response to estradiol stimulus Cellular Component: GO:0005634 nucleus GO:0005694 chromosome GO:0005730 nucleolus GO:0005737 cytoplasm GO:0016020 membrane

Descriptions from all associated GenBank mRNAs


	LF205329 - JP 2014500723-A/12832: Polycomb-Associated Non-Coding RNAs. BC024739 - Homo sapiens DEAD (Asp-Glu-Ala-Asp) box polypeptide 18, mRNA (cDNA clone MGC:29902 IMAGE:4995871), complete cds. AK001467 - Homo sapiens cDNA FLJ10605 fis, clone NT2RP2005126, highly similar to H.sapiens mRNA for RNA helicase. JD307585 - Sequence 288609 from Patent EP1572962. BC003360 - Homo sapiens DEAD (Asp-Glu-Ala-Asp) box polypeptide 18, mRNA (cDNA clone MGC:5316 IMAGE:2900252), complete cds. BC001238 - Homo sapiens DEAD (Asp-Glu-Ala-Asp) box polypeptide 18, mRNA (cDNA clone MGC:4933 IMAGE:3452935), complete cds. LF319362 - JP 2014500723-A/126865: Polycomb-Associated Non-Coding RNAs. KJ897930 - Synthetic construct Homo sapiens clone ccsbBroadEn_07324 DDX18 gene, encodes complete protein. X98743 - H.sapiens mRNA for RNA helicase (Myc-regulated dead box protein). CR457060 - Homo sapiens full open reading frame cDNA clone RZPDo834G0414D for gene DDX18, DEAD (Asp-Glu-Ala-Asp) box polypeptide 18; complete cds, incl. stopcodon. LF319358 - JP 2014500723-A/126861: Polycomb-Associated Non-Coding RNAs. LF319357 - JP 2014500723-A/126860: Polycomb-Associated Non-Coding RNAs. LF319355 - JP 2014500723-A/126858: Polycomb-Associated Non-Coding RNAs. AK091227 - Homo sapiens cDNA FLJ33908 fis, clone CTONG2008518, highly similar to DEAD/H (Asp-Glu-Ala-Asp/His) box polypeptide 18. LF319354 - JP 2014500723-A/126857: Polycomb-Associated Non-Coding RNAs. LF319232 - JP 2014500723-A/126735: Polycomb-Associated Non-Coding RNAs. LF319353 - JP 2014500723-A/126856: Polycomb-Associated Non-Coding RNAs. AB209392 - Homo sapiens mRNA for Hypothetical protein FLJ33908 variant protein. LF319351 - JP 2014500723-A/126854: Polycomb-Associated Non-Coding RNAs. LF319350 - JP 2014500723-A/126853: Polycomb-Associated Non-Coding RNAs. LF319349 - JP 2014500723-A/126852: Polycomb-Associated Non-Coding RNAs. LF319346 - JP 2014500723-A/126849: Polycomb-Associated Non-Coding RNAs. LF319344 - JP 2014500723-A/126847: Polycomb-Associated Non-Coding RNAs. JD327453 - Sequence 308477 from Patent EP1572962. JD082489 - Sequence 63513 from Patent EP1572962. BX538334 - Homo sapiens mRNA; cDNA DKFZp686O01204 (from clone DKFZp686O01204). JD566298 - Sequence 547322 from Patent EP1572962. JD508840 - Sequence 489864 from Patent EP1572962. JD254514 - Sequence 235538 from Patent EP1572962. MA440906 - JP 2018138019-A/12832: Polycomb-Associated Non-Coding RNAs. MA554939 - JP 2018138019-A/126865: Polycomb-Associated Non-Coding RNAs. MA554935 - JP 2018138019-A/126861: Polycomb-Associated Non-Coding RNAs. MA554934 - JP 2018138019-A/126860: Polycomb-Associated Non-Coding RNAs. MA554932 - JP 2018138019-A/126858: Polycomb-Associated Non-Coding RNAs. MA554931 - JP 2018138019-A/126857: Polycomb-Associated Non-Coding RNAs. MA554809 - JP 2018138019-A/126735: Polycomb-Associated Non-Coding RNAs. MA554930 - JP 2018138019-A/126856: Polycomb-Associated Non-Coding RNAs. MA554928 - JP 2018138019-A/126854: Polycomb-Associated Non-Coding RNAs. MA554927 - JP 2018138019-A/126853: Polycomb-Associated Non-Coding RNAs. MA554926 - JP 2018138019-A/126852: Polycomb-Associated Non-Coding RNAs. MA554923 - JP 2018138019-A/126849: Polycomb-Associated Non-Coding RNAs. MA554921 - JP 2018138019-A/126847: Polycomb-Associated Non-Coding RNAs.

Other Names for This Gene


	Alternate Gene Symbols: cPERP-D , DDX18_HUMAN, ENST00000263239.1, ENST00000263239.2, ENST00000263239.3, ENST00000263239.4, ENST00000263239.5, ENST00000263239.6, NM_006773, Q6GTZ9, Q6IAU4, Q92732, Q9BQB7, Q9NVP1, uc317hhs.1, uc317hhs.2 UCSC ID: ENST00000263239.7_4 RefSeq Accession: NM_006773.4 Protein: Q9NVP1 (aka DDX18_HUMAN or DD18_HUMAN)

Gene Model Information


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Methods, Credits, and Use Restrictions


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