ID:4ET_HUMAN DESCRIPTION: RecName: Full=Eukaryotic translation initiation factor 4E transporter; Short=4E-T; Short=eIF4E transporter; AltName: Full=Eukaryotic translation initiation factor 4E nuclear import factor 1; FUNCTION: Nucleoplasmic shuttling protein. Mediates the nuclear import of EIF4E by a piggy-back mechanism. SUBUNIT: Interacts with EIF4E. Interacts with importin beta only in the presence of importin alpha, suggesting a direct interaction with importin alpha. INTERACTION: P06730:EIF4E; NbExp=5; IntAct=EBI-301024, EBI-73440; O60573:EIF4E2; NbExp=3; IntAct=EBI-301024, EBI-398610; SUBCELLULAR LOCATION: Cytoplasm. Nucleus. Nucleus, PML body. Nucleus speckle. Note=Predominantly cytoplasmic. Shuttles between the nucleus and the cytoplasm in a CRM1-dependent manner. Localization to nuclear foci and speckles requires active transcription. TISSUE SPECIFICITY: Widely expressed. SEQUENCE CAUTION: Sequence=BAB15092.1; Type=Erroneous initiation; Sequence=BAC11194.1; Type=Erroneous initiation;
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
Pfam Domains: PF10477 - Nucleocytoplasmic shuttling protein for mRNA cap-binding EIF4E
ModBase Predicted Comparative 3D Structure on Q9NRA8
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
Biological Process: GO:0015031 protein transport GO:0017148 negative regulation of translation GO:0019827 stem cell population maintenance GO:0045665 negative regulation of neuron differentiation