Human Gene EPHA10 (ENST00000373048.9_12) from GENCODE V47lift37
  Description: EPH receptor A10, transcript variant 3 (from RefSeq NM_001099439.2)
Gencode Transcript: ENST00000373048.9_12
Gencode Gene: ENSG00000183317.17_15
Transcript (Including UTRs)
   Position: hg19 chr1:38,181,648-38,230,792 Size: 49,145 Total Exon Count: 17 Strand: -
Coding Region
   Position: hg19 chr1:38,184,044-38,230,738 Size: 46,695 Coding Exon Count: 17 

Page IndexSequence and LinksUniProtKB CommentsPrimersCTDGene Alleles
RNA-Seq ExpressionMicroarray ExpressionRNA StructureProtein StructureOther SpeciesGO Annotations
mRNA DescriptionsPathwaysOther NamesModel InformationMethods
Data last updated at UCSC: 2024-08-22 23:36:26

-  Sequence and Links to Tools and Databases
 
Genomic Sequence (chr1:38,181,648-38,230,792)mRNA (may differ from genome)Protein (1008 aa)
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-  Comments and Description Text from UniProtKB
  ID: EPHAA_HUMAN
DESCRIPTION: RecName: Full=Ephrin type-A receptor 10; EC=2.7.10.1; Flags: Precursor;
FUNCTION: Receptor for members of the ephrin-A family. Binds to EFNA3, EFNA4 and EFNA5.
CATALYTIC ACTIVITY: ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate.
SUBCELLULAR LOCATION: Isoform 1: Cell membrane; Single-pass type I membrane protein (Probable).
SUBCELLULAR LOCATION: Isoform 3: Cell membrane; Single-pass type I membrane protein (Probable).
SUBCELLULAR LOCATION: Isoform 2: Secreted (Probable).
TISSUE SPECIFICITY: Mainly expressed in testis.
DOMAIN: The protein kinase domain is predicted to be catalytically inactive.
SIMILARITY: Belongs to the protein kinase superfamily. Tyr protein kinase family. Ephrin receptor subfamily.
SIMILARITY: Contains 1 Eph LBD (Eph ligand-binding) domain.
SIMILARITY: Contains 2 fibronectin type-III domains.
SIMILARITY: Contains 1 protein kinase domain.
SIMILARITY: Contains 1 SAM (sterile alpha motif) domain.
SEQUENCE CAUTION: Sequence=AAI12934.1; Type=Erroneous initiation; Note=Translation N-terminally extended;

-  Primer design for this transcript
 

Primer3Plus can design qPCR Primers that straddle exon-exon-junctions, which amplify only cDNA, not genomic DNA.
Click here to load the transcript sequence and exon structure into Primer3Plus

Exonprimer can design one pair of Sanger sequencing primers around every exon, located in non-genic sequence.
Click here to open Exonprimer with this transcript

To design primers for a non-coding sequence, zoom to a region of interest and select from the drop-down menu: View > In External Tools > Primer3


-  Comparative Toxicogenomics Database (CTD)
  The following chemicals interact with this gene

+  Common Gene Haplotype Alleles
  Press "+" in the title bar above to open this section.

-  RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
  Highest median expression: 14.85 RPKM in Testis
Total median expression: 70.54 RPKM



View in GTEx track of Genome Browser    View at GTEx portal     View GTEx Body Map

+  Microarray Expression Data
  Press "+" in the title bar above to open this section.

-  mRNA Secondary Structure of 3' and 5' UTRs
 
RegionFold EnergyBasesEnergy/Base
Display As
5' UTR -26.8054-0.496 Picture PostScript Text
3' UTR -1090.502396-0.455 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Protein Domain and Structure Information
  InterPro Domains: Graphical view of domain structure
IPR001090 - Ephrin_rcpt_lig-bd_dom
IPR003961 - Fibronectin_type3
IPR008979 - Galactose-bd-like
IPR013783 - Ig-like_fold
IPR011009 - Kinase-like_dom
IPR000719 - Prot_kinase_cat_dom
IPR001660 - SAM
IPR013761 - SAM/pointed
IPR021129 - SAM_type1
IPR001245 - Ser-Thr/Tyr_kinase_cat_dom
IPR020635 - Tyr_kinase_cat_dom
IPR016257 - Tyr_kinase_ephrin_rcpt
IPR001426 - Tyr_kinase_rcpt_V_CS

Pfam Domains:
PF00041 - Fibronectin type III domain
PF00069 - Protein kinase domain
PF00536 - SAM domain (Sterile alpha motif)
PF01404 - Ephrin receptor ligand binding domain
PF07647 - SAM domain (Sterile alpha motif)
PF07714 - Protein tyrosine and serine/threonine kinase
PF14575 - Ephrin type-A receptor 2 transmembrane domain

SCOP Domains:
47769 - SAM/Pointed domain
49363 - Purple acid phosphatase, N-terminal domain
49265 - Fibronectin type III
49785 - Galactose-binding domain-like
56112 - Protein kinase-like (PK-like)
57184 - Growth factor receptor domain

ModBase Predicted Comparative 3D Structure on Q5JZY3
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The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
MouseRatZebrafishD. melanogasterC. elegansS. cerevisiae
No orthologNo orthologNo orthologNo orthologNo orthologNo ortholog
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-  Gene Ontology (GO) Annotations with Structured Vocabulary
  Molecular Function:
GO:0000166 nucleotide binding
GO:0004672 protein kinase activity
GO:0004713 protein tyrosine kinase activity
GO:0004714 transmembrane receptor protein tyrosine kinase activity
GO:0005003 ephrin receptor activity
GO:0005005 transmembrane-ephrin receptor activity
GO:0005515 protein binding
GO:0005524 ATP binding
GO:0016301 kinase activity
GO:0016740 transferase activity

Biological Process:
GO:0006468 protein phosphorylation
GO:0007169 transmembrane receptor protein tyrosine kinase signaling pathway
GO:0008150 biological_process
GO:0016310 phosphorylation
GO:0018108 peptidyl-tyrosine phosphorylation
GO:0048013 ephrin receptor signaling pathway

Cellular Component:
GO:0005576 extracellular region
GO:0005886 plasma membrane
GO:0005887 integral component of plasma membrane
GO:0016020 membrane
GO:0016021 integral component of membrane


-  Descriptions from all associated GenBank mRNAs
  AY726560 - Homo sapiens clone TESTIS-604 mRNA sequence.
BC112933 - Homo sapiens EPH receptor A10, mRNA (cDNA clone IMAGE:5165393), complete cds.
BC041360 - Homo sapiens EPH receptor A10, mRNA (cDNA clone IMAGE:5273054), complete cds.
AK131215 - Homo sapiens cDNA FLJ16103 fis, clone TESTI2016663, moderately similar to EPHRIN TYPE-A RECEPTOR 7 PRECURSOR (EC 2.7.1.112).
JD221658 - Sequence 202682 from Patent EP1572962.
BC039363 - Homo sapiens cDNA clone IMAGE:5270672.
AK309089 - Homo sapiens cDNA, FLJ99130.
JD518237 - Sequence 499261 from Patent EP1572962.
JD464122 - Sequence 445146 from Patent EP1572962.
JD271578 - Sequence 252602 from Patent EP1572962.
JD100279 - Sequence 81303 from Patent EP1572962.
JD075138 - Sequence 56162 from Patent EP1572962.
JD195416 - Sequence 176440 from Patent EP1572962.
JD537607 - Sequence 518631 from Patent EP1572962.
JD101225 - Sequence 82249 from Patent EP1572962.
JD425036 - Sequence 406060 from Patent EP1572962.
JD405953 - Sequence 386977 from Patent EP1572962.
AB372592 - Homo sapiens RNA, has-miR-mizuguchi-20, complete sequence.
AJ781169 - Homo sapiens mRNA for EphA10s protein.
BC067734 - Homo sapiens EPH receptor A10, mRNA (cDNA clone MGC:86967 IMAGE:4375803), complete cds.
AK090974 - Homo sapiens cDNA FLJ33655 fis, clone BRAMY2025121, moderately similar to EPHRIN TYPE-A RECEPTOR 7 PRECURSOR (EC 2.7.1.112).
AX746712 - Sequence 237 from Patent EP1308459.
KJ906478 - Synthetic construct Homo sapiens clone ccsbBroadEn_16148 EPHA10 gene, encodes complete protein.

-  Biochemical and Signaling Pathways
  Reactome (by CSHL, EBI, and GO)

Protein Q5JZY3 (Reactome details) participates in the following event(s):

R-HSA-3928646 EPHAs bind EFNAs
R-HSA-3928597 EPH:EFN dimers tetramerise
R-HSA-2682334 EPH-Ephrin signaling
R-HSA-3928665 EPH-ephrin mediated repulsion of cells
R-HSA-422475 Axon guidance
R-HSA-1266738 Developmental Biology

-  Other Names for This Gene
  Alternate Gene Symbols: A4FU89, ENST00000373048.1, ENST00000373048.2, ENST00000373048.3, ENST00000373048.4, ENST00000373048.5, ENST00000373048.6, ENST00000373048.7, ENST00000373048.8, EPHAA_HUMAN, J3KPB5, NM_001099439, Q5JZY3, Q6NW42, uc318kle.1, uc318kle.2
UCSC ID: ENST00000373048.9_12
RefSeq Accession: NM_001099439.2
Protein: Q5JZY3 (aka EPHAA_HUMAN)

-  Gene Model Information
  Click here for a detailed description of the fields of the table above.

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.