ID:ERAL1_HUMAN DESCRIPTION: RecName: Full=GTPase Era, mitochondrial; Short=H-ERA; Short=hERA; AltName: Full=Conserved ERA-like GTPase; Short=CEGA; AltName: Full=ERA-W; AltName: Full=ERA-like protein 1; Flags: Precursor; FUNCTION: Probable GTPase that plays a role in the mitochondrial ribosomal small subunit assembly. Specifically binds the 12S mitochondrial rRNA (12S mt-rRNA) to a 33 nucleotide section delineating the 3' terminal stem-loop region. May act as a chaperone that protects the 12S mt-rRNA on the 28S mitoribosomal subunit during ribosomal small subunit assembly. SUBCELLULAR LOCATION: Mitochondrion matrix. Mitochondrion inner membrane; Peripheral membrane protein. Note=Localizes on the matrix side on the mitochondrial inner membrane. SIMILARITY: Belongs to the Era/MnmE GTP-binding protein family. Era subfamily. SIMILARITY: Contains 1 G (guanine nucleotide-binding) domain. SIMILARITY: Contains 1 KH type-2 domain. SEQUENCE CAUTION: Sequence=AAG12978.1; Type=Erroneous initiation; Note=Translation N-terminally shortened;
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
Pfam Domains: PF01926 - 50S ribosome-binding GTPase PF02421 - Ferrous iron transport protein B PF04548 - AIG1 family
SCOP Domains: 52540 - P-loop containing nucleoside triphosphate hydrolases 53795 - PEP carboxykinase-like 54791 - Eukaryotic type KH-domain (KH-domain type I) 54814 - Prokaryotic type KH domain (KH-domain type II)
ModBase Predicted Comparative 3D Structure on O75616
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
US Server
Sequence and Links to Tools and Databases 
Common Gene Haplotype Alleles 
