Human Gene ESRRB (ENST00000644823.1_7) from GENCODE V47lift37

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Description: estrogen related receptor beta, transcript variant 2 (from RefSeq NM_001379180.1)
Gencode Transcript: ENST00000644823.1_7
Gencode Gene: ENSG00000119715.15_13
Transcript (Including UTRs)
Position: hg19 chr14:76,842,480-76,968,180 Size: 125,701 Total Exon Count: 7 Strand: +
Coding Region
Position: hg19 chr14:76,842,745-76,964,801 Size: 122,057 Coding Exon Count: 7

Page Index	Sequence and Links	Primers	MalaCards	CTD	Gene Alleles
Microarray Expression	RNA Structure	Other Species	mRNA Descriptions	Other Names	GeneReviews
Model Information	Methods

Data last updated at UCSC: 2024-08-22 23:36:26

Sequence and Links to Tools and Databases

Genomic Sequence (chr14:76,842,480-76,968,180)			mRNA (may differ from genome)		Protein (454 aa)
Gene Sorter	Genome Browser	Other Species FASTA	VisiGene	Gene interactions	Table Schema
AlphaFold	BioGPS	Ensembl	Entrez Gene	ExonPrimer	GeneCards
HGNC	Malacards	MGI	OMIM	PubMed	UniProtKB
Wikipedia	BioGrid CRISPR DB

Primer design for this transcript

Primer3Plus can design qPCR Primers that straddle exon-exon-junctions, which amplify only cDNA, not genomic DNA.
Click here to load the transcript sequence and exon structure into Primer3Plus

Exonprimer can design one pair of Sanger sequencing primers around every exon, located in non-genic sequence.
Click here to open Exonprimer with this transcript

To design primers for a non-coding sequence, zoom to a region of interest and select from the drop-down menu: View > In External Tools > Primer3

MalaCards Disease Associations


	MalaCards Gene Search: ESRRB Diseases sorted by gene-association score: deafness, autosomal recessive 35* (1249), dfnb35 nonsyndromic hearing loss and deafness* (100), autosomal recessive non-syndromic sensorineural deafness type dfnb* (47), deafness, autosomal recessive (14), adrenal hypoplasia, congenital (7), vulva squamous cell carcinoma (5) * = Manually curated disease association

Comparative Toxicogenomics Database (CTD)


	The following chemicals interact with this gene D004054 Diethylstilbestrol D001564 Benzo(a)pyrene D000643 Ammonium Chloride D002945 Cisplatin D019833 Genistein D007529 Isoflavones C501618 N'-((1E)-(4-(diethylamino)phenyl)methylene)-4-hydroxybenzohydrazide D014635 Valproic Acid D014640 Vancomycin C004541 biochanin A more ... click here to view the complete list

Common Gene Haplotype Alleles


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Microarray Expression Data


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mRNA Secondary Structure of 3' and 5' UTRs

Region	Fold Energy	Bases	Energy/Base	Display As
5' UTR	-94.40	265	-0.356	Picture	PostScript	Text
3' UTR	-1333.70	3379	-0.395	Picture	PostScript	Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

Orthologous Genes in Other Species

Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.

Mouse	Rat	Zebrafish	D. melanogaster	C. elegans	S. cerevisiae
No ortholog	No ortholog	No ortholog	No ortholog	No ortholog	No ortholog
Gene Details	Gene Details
Gene Sorter	Gene Sorter
	RGD

Descriptions from all associated GenBank mRNAs


	AF094517 - Homo sapiens nuclear receptor ERRB2 (ERRB2) mRNA, complete cds. BC131517 - Homo sapiens estrogen-related receptor beta, mRNA (cDNA clone IMAGE:40084639), partial cds. AY451389 - Homo sapiens estrogen receptor-related receptor beta short form (ESRRB) mRNA, complete cds, alternatively spliced. AY451390 - Homo sapiens estrogen receptor-related receptor beta2-delta-10 (ESRRB) mRNA, complete cds, alternatively spliced. AB307714 - Homo sapiens NR3B2 mRNA for estrogen-related receptor beta, complete cds. AB463612 - Synthetic construct DNA, clone: pF1KB9737, Homo sapiens ESRRB gene for estrogen-related receptor beta, without stop codon, in Flexi system. BC148477 - Synthetic construct Homo sapiens clone IMAGE:100015441, MGC:183036 estrogen-related receptor beta (ESRRB) mRNA, encodes complete protein. HQ692852 - Homo sapiens estrogen-related nuclear receptor beta (NR3B2) mRNA, complete cds. AK096020 - Homo sapiens cDNA FLJ38701 fis, clone KIDNE2002198. JD054903 - Sequence 35927 from Patent EP1572962. JD162358 - Sequence 143382 from Patent EP1572962. JD374653 - Sequence 355677 from Patent EP1572962. JD064876 - Sequence 45900 from Patent EP1572962. JD137452 - Sequence 118476 from Patent EP1572962. JD370081 - Sequence 351105 from Patent EP1572962. JD338978 - Sequence 320002 from Patent EP1572962. JD118353 - Sequence 99377 from Patent EP1572962. JD236646 - Sequence 217670 from Patent EP1572962. JD042199 - Sequence 23223 from Patent EP1572962. JD336309 - Sequence 317333 from Patent EP1572962. JD479106 - Sequence 460130 from Patent EP1572962. JD050451 - Sequence 31475 from Patent EP1572962. JD294764 - Sequence 275788 from Patent EP1572962. JD039641 - Sequence 20665 from Patent EP1572962. JD550817 - Sequence 531841 from Patent EP1572962. JD180168 - Sequence 161192 from Patent EP1572962. JD147841 - Sequence 128865 from Patent EP1572962. JD119053 - Sequence 100077 from Patent EP1572962. JD264540 - Sequence 245564 from Patent EP1572962. JD355799 - Sequence 336823 from Patent EP1572962. JD424877 - Sequence 405901 from Patent EP1572962. JD120258 - Sequence 101282 from Patent EP1572962. JD502645 - Sequence 483669 from Patent EP1572962. JD040065 - Sequence 21089 from Patent EP1572962. JD229316 - Sequence 210340 from Patent EP1572962.

Other Names for This Gene


	Alternate Gene Symbols: A0A2R8Y491, A0A2R8Y491_HUMAN, ESRRB , NM_001379180, uc328kzr.1, uc328kzr.2 UCSC ID: ENST00000644823.1_7 RefSeq Accession: NM_001379180.1

GeneReviews for This Gene


	GeneReviews article(s) related to gene ESRRB: deafness-overview (Genetic Hearing Loss Overview)

Gene Model Information


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Methods, Credits, and Use Restrictions


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