ID:EXOC7_HUMAN DESCRIPTION: RecName: Full=Exocyst complex component 7; AltName: Full=Exocyst complex component Exo70; FUNCTION: Component of the exocyst complex involved in the docking of exocytic vesicles with fusion sites on the plasma membrane. In adipocytes, plays a crucial role in targeting SLC2A4 vesicle to the plasma membrane in response to insulin, perhaps directing the vesicle to the precise site of fusion (By similarity). SUBUNIT: The exocyst complex is composed of EXOC1, EXOC2, EXOC3, EXOC4, EXOC5, EXOC6, EXOC7 and EXOC8. Interacts with ARHQ in a GTP-dependent manner. Interacts with RAB11FIP3 (By similarity). INTERACTION: Q9Y6D5:ARFGEF2; NbExp=4; IntAct=EBI-6251402, EBI-2837511; SUBCELLULAR LOCATION: Cytoplasm, cytosol (By similarity). Cell membrane; Peripheral membrane protein (By similarity). Note=Translocates, as a preformed complex with SEC6 and SEC8, to the plasma membrane in response to insulin through the activation of ARHQ (By similarity). DOMAIN: The N-terminus is involved in SEC8 and ARHQ binding (By similarity). DOMAIN: The C-terminus is required for translocation to the plasma membrane (By similarity). SIMILARITY: Belongs to the EXO70 family. SEQUENCE CAUTION: Sequence=BAA83019.1; Type=Erroneous initiation; Note=Translation N-terminally shortened; Sequence=BAB14095.1; Type=Erroneous initiation; Note=Translation N-terminally extended;
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
ModBase Predicted Comparative 3D Structure on Q9UPT5
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
Biological Process: GO:0006887 exocytosis GO:0015031 protein transport GO:0016241 regulation of macroautophagy GO:2000535 regulation of entry of bacterium into host cell
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Sequence and Links to Tools and Databases 
Common Gene Haplotype Alleles 
