Human Gene FABP1 (ENST00000295834.8_7) from GENCODE V47lift37
  Description: fatty acid binding protein 1 (from RefSeq NM_001443.3)
Gencode Transcript: ENST00000295834.8_7
Gencode Gene: ENSG00000163586.10_9
Transcript (Including UTRs)
   Position: hg19 chr2:88,422,501-88,427,581 Size: 5,081 Total Exon Count: 4 Strand: -
Coding Region
   Position: hg19 chr2:88,422,573-88,427,536 Size: 4,964 Coding Exon Count: 4 

Page IndexSequence and LinksUniProtKB CommentsPrimersMalaCardsCTD
Gene AllelesRNA-Seq ExpressionMicroarray ExpressionRNA StructureProtein StructureOther Species
GO AnnotationsmRNA DescriptionsPathwaysOther NamesModel InformationMethods
Data last updated at UCSC: 2024-08-22 23:36:26

-  Sequence and Links to Tools and Databases
 
Genomic Sequence (chr2:88,422,501-88,427,581)mRNA (may differ from genome)Protein (127 aa)
Gene SorterGenome BrowserOther Species FASTAVisiGeneGene interactionsTable Schema
AlphaFoldBioGPSEnsemblEntrez GeneExonPrimerGeneCards
HGNCMalacardsMGIOMIMPubMedUniProtKB
WikipediaBioGrid CRISPR DB

-  Comments and Description Text from UniProtKB
  ID: Q6FGL7_HUMAN
DESCRIPTION: SubName: Full=FABP1 protein; SubName: Full=Fatty acid binding protein 1, liver, isoform CRA_b; SubName: Full=Putative uncharacterized protein FABP1; Flags: Fragment;
SIMILARITY: Belongs to the calycin superfamily. Fatty-acid binding protein (FABP) family.

-  Primer design for this transcript
 

Primer3Plus can design qPCR Primers that straddle exon-exon-junctions, which amplify only cDNA, not genomic DNA.
Click here to load the transcript sequence and exon structure into Primer3Plus

Exonprimer can design one pair of Sanger sequencing primers around every exon, located in non-genic sequence.
Click here to open Exonprimer with this transcript

To design primers for a non-coding sequence, zoom to a region of interest and select from the drop-down menu: View > In External Tools > Primer3


-  MalaCards Disease Associations
  MalaCards Gene Search: FABP1
Diseases sorted by gene-association score: hepatocellular adenoma (12), chylomicron retention disease (7)

-  Comparative Toxicogenomics Database (CTD)
  The following chemicals interact with this gene           more ... click here to view the complete list

+  Common Gene Haplotype Alleles
  Press "+" in the title bar above to open this section.

-  RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
  Highest median expression: 469.81 RPKM in Liver
Total median expression: 1099.90 RPKM



View in GTEx track of Genome Browser    View at GTEx portal     View GTEx Body Map

+  Microarray Expression Data
  Press "+" in the title bar above to open this section.

-  mRNA Secondary Structure of 3' and 5' UTRs
 
RegionFold EnergyBasesEnergy/Base
Display As
5' UTR -14.5045-0.322 Picture PostScript Text
3' UTR -8.1072-0.113 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Protein Domain and Structure Information
  InterPro Domains: Graphical view of domain structure
IPR012674 - Calycin
IPR011038 - Calycin-like
IPR000463 - Fatty_acid-bd
IPR000566 - Lipocln_cytosolic_FA-bd_dom

Pfam Domains:
PF00061 - Lipocalin / cytosolic fatty-acid binding protein family
PF14651 - Lipocalin / cytosolic fatty-acid binding protein family

SCOP Domains:
50814 - Lipocalins
55718 - SCP-like

ModBase Predicted Comparative 3D Structure on Q6FGL7
FrontTopSide
The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
MouseRatZebrafishD. melanogasterC. elegansS. cerevisiae
No orthologNo orthologNo orthologNo orthologNo orthologNo ortholog
Gene DetailsGene Details    
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 RGDEnsembl   
      
      

-  Gene Ontology (GO) Annotations with Structured Vocabulary
  Molecular Function:
GO:0003682 chromatin binding
GO:0005324 long-chain fatty acid transporter activity
GO:0005504 fatty acid binding
GO:0005543 phospholipid binding
GO:0008144 drug binding
GO:0008289 lipid binding
GO:0032052 bile acid binding

Biological Process:
GO:0015909 long-chain fatty acid transport
GO:0032000 positive regulation of fatty acid beta-oxidation
GO:0050892 intestinal absorption
GO:0051345 positive regulation of hydrolase activity

Cellular Component:
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0005737 cytoplasm
GO:0005782 peroxisomal matrix
GO:0005829 cytosol
GO:0032991 macromolecular complex
GO:0045179 apical cortex


-  Descriptions from all associated GenBank mRNAs
  LF207185 - JP 2014500723-A/14688: Polycomb-Associated Non-Coding RNAs.
BX641099 - Homo sapiens mRNA; cDNA DKFZp686B22229 (from clone DKFZp686B22229).
BC032801 - Homo sapiens fatty acid binding protein 1, liver, mRNA (cDNA clone MGC:45285 IMAGE:5190267), complete cds.
M10617 - Human liver fatty acid binding protein (L-FABP) mRNA, complete cds.
M10050 - Human liver fatty acid binding protein (FABP) mRNA, complete cds.
KJ891140 - Synthetic construct Homo sapiens clone ccsbBroadEn_00534 FABP1 gene, encodes complete protein.
KR710844 - Synthetic construct Homo sapiens clone CCSBHm_00017637 FABP1 (FABP1) mRNA, encodes complete protein.
CR542090 - Homo sapiens full open reading frame cDNA clone RZPDo834A0537D for gene FABP1, fatty acid binding protein 1, liver; complete cds, without stopcodon.
AB527938 - Synthetic construct DNA, clone: pF1KB6791, Homo sapiens FABP1 gene for fatty acid binding protein 1, liver, without stop codon, in Flexi system.
BC022287 - Homo sapiens fatty acid binding protein 1, liver, mRNA (cDNA clone IMAGE:4712653), partial cds.
MA442762 - JP 2018138019-A/14688: Polycomb-Associated Non-Coding RNAs.

-  Biochemical and Signaling Pathways
  BioCarta from NCI Cancer Genome Anatomy Project
h_pparaPathway - Mechanism of Gene Regulation by Peroxisome Proliferators via PPARa(alpha)

-  Other Names for This Gene
  Alternate Gene Symbols: ENST00000295834.1, ENST00000295834.2, ENST00000295834.3, ENST00000295834.4, ENST00000295834.5, ENST00000295834.6, ENST00000295834.7, FABP1 , hCG_32947 , NM_001443, Q6FGL7, Q6FGL7_HUMAN, uc317lon.1, uc317lon.2
UCSC ID: ENST00000295834.8_7
RefSeq Accession: NM_001443.3
Protein: Q6FGL7

-  Gene Model Information
  Click here for a detailed description of the fields of the table above.

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.