Human Gene FABP1 (ENST00000295834.8_7) from GENCODE V47lift37

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Description: fatty acid binding protein 1 (from RefSeq NM_001443.3)
Gencode Transcript: ENST00000295834.8_7
Gencode Gene: ENSG00000163586.10_9
Transcript (Including UTRs)
Position: hg19 chr2:88,422,501-88,427,581 Size: 5,081 Total Exon Count: 4 Strand: -
Coding Region
Position: hg19 chr2:88,422,573-88,427,536 Size: 4,964 Coding Exon Count: 4

Page Index	Sequence and Links	UniProtKB Comments	Primers	MalaCards	CTD
Gene Alleles	RNA-Seq Expression	Microarray Expression	RNA Structure	Protein Structure	Other Species
GO Annotations	mRNA Descriptions	Pathways	Other Names	Model Information	Methods

Data last updated at UCSC: 2024-08-22 23:36:26

Sequence and Links to Tools and Databases

Genomic Sequence (chr2:88,422,501-88,427,581)			mRNA (may differ from genome)		Protein (127 aa)
Gene Sorter	Genome Browser	Other Species FASTA	VisiGene	Gene interactions	Table Schema
AlphaFold	BioGPS	Ensembl	Entrez Gene	ExonPrimer	GeneCards
HGNC	Malacards	MGI	OMIM	PubMed	UniProtKB
Wikipedia	BioGrid CRISPR DB

Comments and Description Text from UniProtKB


	ID: Q6FGL7_HUMAN DESCRIPTION: SubName: Full=FABP1 protein; SubName: Full=Fatty acid binding protein 1, liver, isoform CRA_b; SubName: Full=Putative uncharacterized protein FABP1; Flags: Fragment; SIMILARITY: Belongs to the calycin superfamily. Fatty-acid binding protein (FABP) family.

Primer design for this transcript

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Exonprimer can design one pair of Sanger sequencing primers around every exon, located in non-genic sequence.
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To design primers for a non-coding sequence, zoom to a region of interest and select from the drop-down menu: View > In External Tools > Primer3

MalaCards Disease Associations


	MalaCards Gene Search: FABP1 Diseases sorted by gene-association score: hepatocellular adenoma (12), chylomicron retention disease (7)

Comparative Toxicogenomics Database (CTD)


	The following chemicals interact with this gene D002994 Clofibrate D013749 Tetrachlorodibenzodioxin D000082 Acetaminophen D001629 Bezafibrate D016572 Cyclosporine D004997 Ethinyl Estradiol C076994 perfluorooctane sulfonic acid C006253 pirinixic acid D001564 Benzo(a)pyrene D002945 Cisplatin C425931 GW 501516 D008727 Methotrexate D010831 Phytanic Acid D013629 Tamoxifen D013752 Tetracycline C089730 rosiglitazone C501413 tesaglitazar C057693 troglitazone C026486 1,2,5,6-dibenzanthracene C028474 1,4-bis(2-(3,5-dichloropyridyloxy))benzene C576882 1-(2-trifluoromethoxyphenyl)-2-nitroethanone D015058 1-Naphthylisothiocyanate C457499 2-chloro-5-nitrobenzanilide C021756 2-tetradecylglycidic acid D015124 8-Bromo Cyclic Adenosine Monophosphate D016604 Aflatoxin B1 D000638 Amiodarone D000639 Amitriptyline D000643 Ammonium Chloride D001647 Bile Acids and Salts D002087 Butyrates D019256 Cadmium Chloride D002251 Carbon Tetrachloride D002713 Chlorine D002725 Chloroform D002737 Chloroprene D002746 Chlorpromazine D002794 Choline D015283 Citalopram D002997 Clomipramine D003024 Clozapine D019327 Copper Sulfate D003314 Corn Oil D003687 Dehydroepiandrosterone D019314 Dehydroepiandrosterone Sulfate D003907 Dexamethasone D004008 Diclofenac D004041 Dietary Fats D004051 Diethylhexyl Phthalate D004052 Diethylnitrosamine D004128 Dimethylnitrosamine D004137 Dinitrochlorobenzene D004316 Doxepin D004785 Environmental Pollutants D004917 Erythromycin D004918 Erythromycin Estolate D004958 Estradiol D000431 Ethanol D011345 Fenofibrate D005395 Fish Oils D005424 Flecainide D005473 Fluoxetine D006118 Griseofulvin D006861 Hydrogen Peroxide D007099 Imipramine D007654 Ketoconazole D019787 Linoleic Acid D008070 Lipopolysaccharides D017336 Loratadine C568376 MT19c compound D008701 Methapyrilene D008715 Methionine C002741 N-nitrosomorpholine D009525 Niacin D019301 Oleic Acid D010081 Oxazolone D010126 Ozone D010419 Pentamidine D010480 Perhexiline D010634 Phenobarbital D010936 Plant Extracts D011078 Polychlorinated Biphenyls D011794 Quercetin D011802 Quinidine C488333 Ro 65-7199 C488334 Ro 66-0074 D020280 Sertraline D012906 Smoke D053260 Soot D013096 Spermine D013806 Theophylline D013881 Thioridazine D014028 Tobacco Smoke Pollution D014051 Toluene 2,4-Diisocyanate D014635 Valproic Acid D024483 Vitamin K 3 D015031 Zimeldine D015032 Zinc C059765 amphotericin B, deoxycholate drug combination C006703 benzo(b)fluoranthene C095105 bexarotene C032036 bromobenzene C084597 chlorcyclizine C074702 chromium hexavalent ion C039671 ciglitazone C018021 cobaltous chloride C041517 dibenzo(a,l)pyrene C014476 diethyl maleate C054207 etomoxir C006012 fenofibric acid C007738 fluoranthene C056933 fumonisin B1 C039281 furan C029424 hydrazine C051890 irinotecan C482199 lipopolysaccharide, E coli O55-B5 C500085 muraglitazar C022838 nickel chloride C488250 oleoylethanolamide C471071 perfluorohexanesulfonic acid C023036 perfluorooctanoic acid C027579 periodate-oxidized adenosine C016104 sodium bichromate C025462 sulindac sulfide D001371 trans-1,4-Bis(2-chlorobenzaminomethyl)cyclohexane Dihydrochloride C072782 tri-(2-chloroisopropyl)phosphate C015559 trimellitic anhydride C016805 tris(1,3-dichloro-2-propyl)phosphate C016837 zinc chloride

Common Gene Haplotype Alleles


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RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)


	Highest median expression: 469.81 RPKM in Liver Total median expression: 1099.90 RPKM View in GTEx track of Genome Browser View at GTEx portal View GTEx Body Map

Microarray Expression Data


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mRNA Secondary Structure of 3' and 5' UTRs

Region	Fold Energy	Bases	Energy/Base	Display As
5' UTR	-14.50	45	-0.322	Picture	PostScript	Text
3' UTR	-8.10	72	-0.113	Picture	PostScript	Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

Protein Domain and Structure Information

InterPro Domains: Graphical view of domain structure
IPR012674 - Calycin
IPR011038 - Calycin-like
IPR000463 - Fatty_acid-bd
IPR000566 - Lipocln_cytosolic_FA-bd_dom

Pfam Domains:
PF00061 - Lipocalin / cytosolic fatty-acid binding protein family
PF14651 - Lipocalin / cytosolic fatty-acid binding protein family

SCOP Domains:
50814 - Lipocalins
55718 - SCP-like

ModBase Predicted Comparative 3D Structure on Q6FGL7


Front	Top	Side

The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

Orthologous Genes in Other Species

Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.

Mouse	Rat	Zebrafish	D. melanogaster	C. elegans	S. cerevisiae
No ortholog	No ortholog	No ortholog	No ortholog	No ortholog	No ortholog
Gene Details	Gene Details
Gene Sorter	Gene Sorter
	RGD	Ensembl

Gene Ontology (GO) Annotations with Structured Vocabulary


	Molecular Function: GO:0003682 chromatin binding GO:0005324 long-chain fatty acid transporter activity GO:0005504 fatty acid binding GO:0005543 phospholipid binding GO:0008144 drug binding GO:0008289 lipid binding GO:0032052 bile acid binding Biological Process: GO:0015909 long-chain fatty acid transport GO:0032000 positive regulation of fatty acid beta-oxidation GO:0050892 intestinal absorption GO:0051345 positive regulation of hydrolase activity Cellular Component: GO:0005634 nucleus GO:0005654 nucleoplasm GO:0005737 cytoplasm GO:0005782 peroxisomal matrix GO:0005829 cytosol GO:0032991 macromolecular complex GO:0045179 apical cortex

Descriptions from all associated GenBank mRNAs


	LF207185 - JP 2014500723-A/14688: Polycomb-Associated Non-Coding RNAs. BX641099 - Homo sapiens mRNA; cDNA DKFZp686B22229 (from clone DKFZp686B22229). BC032801 - Homo sapiens fatty acid binding protein 1, liver, mRNA (cDNA clone MGC:45285 IMAGE:5190267), complete cds. M10617 - Human liver fatty acid binding protein (L-FABP) mRNA, complete cds. M10050 - Human liver fatty acid binding protein (FABP) mRNA, complete cds. KJ891140 - Synthetic construct Homo sapiens clone ccsbBroadEn_00534 FABP1 gene, encodes complete protein. KR710844 - Synthetic construct Homo sapiens clone CCSBHm_00017637 FABP1 (FABP1) mRNA, encodes complete protein. CR542090 - Homo sapiens full open reading frame cDNA clone RZPDo834A0537D for gene FABP1, fatty acid binding protein 1, liver; complete cds, without stopcodon. AB527938 - Synthetic construct DNA, clone: pF1KB6791, Homo sapiens FABP1 gene for fatty acid binding protein 1, liver, without stop codon, in Flexi system. BC022287 - Homo sapiens fatty acid binding protein 1, liver, mRNA (cDNA clone IMAGE:4712653), partial cds. MA442762 - JP 2018138019-A/14688: Polycomb-Associated Non-Coding RNAs.

Biochemical and Signaling Pathways


	BioCarta from NCI Cancer Genome Anatomy Project h_pparaPathway - Mechanism of Gene Regulation by Peroxisome Proliferators via PPARa(alpha)

Other Names for This Gene


	Alternate Gene Symbols: ENST00000295834.1, ENST00000295834.2, ENST00000295834.3, ENST00000295834.4, ENST00000295834.5, ENST00000295834.6, ENST00000295834.7, FABP1 , hCG_32947 , NM_001443, Q6FGL7, Q6FGL7_HUMAN, uc317lon.1, uc317lon.2 UCSC ID: ENST00000295834.8_7 RefSeq Accession: NM_001443.3 Protein: Q6FGL7

Gene Model Information


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Methods, Credits, and Use Restrictions


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