Human Gene FABP3 (ENST00000373713.7_8) from GENCODE V47lift37
  Description: fatty acid binding protein 3, transcript variant 2 (from RefSeq NM_004102.5)
Gencode Transcript: ENST00000373713.7_8
Gencode Gene: ENSG00000121769.8_16
Transcript (Including UTRs)
   Position: hg19 chr1:31,838,100-31,845,923 Size: 7,824 Total Exon Count: 4 Strand: -
Coding Region
   Position: hg19 chr1:31,838,733-31,845,861 Size: 7,129 Coding Exon Count: 4 

Page IndexSequence and LinksUniProtKB CommentsPrimersMalaCardsCTD
Gene AllelesRNA-Seq ExpressionMicroarray ExpressionRNA StructureProtein StructureOther Species
GO AnnotationsmRNA DescriptionsPathwaysOther NamesModel InformationMethods
Data last updated at UCSC: 2024-08-22 23:36:26

-  Sequence and Links to Tools and Databases
 
Genomic Sequence (chr1:31,838,100-31,845,923)mRNA (may differ from genome)Protein (133 aa)
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UniProtKBWikipediaBioGrid CRISPR DB

-  Comments and Description Text from UniProtKB
  ID: FABPH_HUMAN
DESCRIPTION: RecName: Full=Fatty acid-binding protein, heart; AltName: Full=Fatty acid-binding protein 3; AltName: Full=Heart-type fatty acid-binding protein; Short=H-FABP; AltName: Full=Mammary-derived growth inhibitor; Short=MDGI; AltName: Full=Muscle fatty acid-binding protein; Short=M-FABP;
FUNCTION: FABP are thought to play a role in the intracellular transport of long-chain fatty acids and their acyl-CoA esters.
INTERACTION: P05556:ITGB1; NbExp=2; IntAct=EBI-704216, EBI-703066;
SUBCELLULAR LOCATION: Cytoplasm.
DOMAIN: Forms a beta-barrel structure that accommodates the hydrophobic ligand in its interior.
SIMILARITY: Belongs to the calycin superfamily. Fatty-acid binding protein (FABP) family.

-  Primer design for this transcript
 

Primer3Plus can design qPCR Primers that straddle exon-exon-junctions, which amplify only cDNA, not genomic DNA.
Click here to load the transcript sequence and exon structure into Primer3Plus

Exonprimer can design one pair of Sanger sequencing primers around every exon, located in non-genic sequence.
Click here to open Exonprimer with this transcript

To design primers for a non-coding sequence, zoom to a region of interest and select from the drop-down menu: View > In External Tools > Primer3


-  MalaCards Disease Associations
  MalaCards Gene Search: FABP3
Diseases sorted by gene-association score: acute myocardial infarction (16), intermediate charcot-marie-tooth neuropathy (13), pulmonary embolism (11), cerebral creatine deficiency syndrome 1 (6), juxtacortical osteosarcoma (6), peripheral osteosarcoma (5), methylmalonic aciduria and homocystinuria, cblc type (5), cerebral creatine deficiency syndrome (4), heart disease (4), myocardial infarction (4), congestive heart failure (3), dilated cardiomyopathy (1)

-  Comparative Toxicogenomics Database (CTD)
  The following chemicals interact with this gene           more ... click here to view the complete list

+  Common Gene Haplotype Alleles
  Press "+" in the title bar above to open this section.

-  RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
  Highest median expression: 1680.46 RPKM in Heart - Left Ventricle
Total median expression: 3960.63 RPKM



View in GTEx track of Genome Browser    View at GTEx portal     View GTEx Body Map

+  Microarray Expression Data
  Press "+" in the title bar above to open this section.

-  mRNA Secondary Structure of 3' and 5' UTRs
 
RegionFold EnergyBasesEnergy/Base
Display As
5' UTR -7.3062-0.118 Picture PostScript Text
3' UTR -184.70633-0.292 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Protein Domain and Structure Information
  InterPro Domains: Graphical view of domain structure
IPR012674 - Calycin
IPR011038 - Calycin-like
IPR000463 - Fatty_acid-bd
IPR000566 - Lipocln_cytosolic_FA-bd_dom

Pfam Domains:
PF00061 - Lipocalin / cytosolic fatty-acid binding protein family
PF14651 - Lipocalin / cytosolic fatty-acid binding protein family

SCOP Domains:
50814 - Lipocalins

Protein Data Bank (PDB) 3-D Structure
MuPIT help
1G5W - NMR MuPIT 1HMR - X-ray MuPIT 1HMS - X-ray MuPIT 1HMT - X-ray MuPIT 2HMB - X-ray MuPIT 3RSW - X-ray MuPIT


ModBase Predicted Comparative 3D Structure on P05413
FrontTopSide
The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
MouseRatZebrafishD. melanogasterC. elegansS. cerevisiae
No orthologNo orthologNo orthologNo orthologGenome BrowserNo ortholog
Gene DetailsGene Details  Gene Details 
Gene SorterGene Sorter  Gene Sorter 
 RGDEnsembl WormBase 
    Protein Sequence 
    Alignment 

-  Gene Ontology (GO) Annotations with Structured Vocabulary
  Molecular Function:
GO:0005324 long-chain fatty acid transporter activity
GO:0005504 fatty acid binding
GO:0005515 protein binding
GO:0008092 cytoskeletal protein binding
GO:0008289 lipid binding
GO:0036041 long-chain fatty acid binding
GO:0050543 icosatetraenoic acid binding
GO:0070538 oleic acid binding

Biological Process:
GO:0006631 fatty acid metabolic process
GO:0008285 negative regulation of cell proliferation
GO:0015909 long-chain fatty acid transport
GO:0019433 triglyceride catabolic process
GO:0032868 response to insulin
GO:0042493 response to drug
GO:0042632 cholesterol homeostasis
GO:0044539 long-chain fatty acid import
GO:0046320 regulation of fatty acid oxidation
GO:0055091 phospholipid homeostasis
GO:0070542 response to fatty acid
GO:0071073 positive regulation of phospholipid biosynthetic process
GO:2001245 regulation of phosphatidylcholine biosynthetic process

Cellular Component:
GO:0005615 extracellular space
GO:0005737 cytoplasm
GO:0005829 cytosol
GO:0016528 sarcoplasm
GO:0070062 extracellular exosome


-  Descriptions from all associated GenBank mRNAs
  BC007021 - Homo sapiens fatty acid binding protein 3, muscle and heart (mammary-derived growth inhibitor), mRNA (cDNA clone MGC:12366 IMAGE:3934295), complete cds.
GQ900955 - Homo sapiens clone HEL-T-67 epididymis secretory sperm binding protein mRNA, complete cds.
LF206640 - JP 2014500723-A/14143: Polycomb-Associated Non-Coding RNAs.
LF213883 - JP 2014500723-A/21386: Polycomb-Associated Non-Coding RNAs.
Y10255 - H.sapiens mRNA for mammary-derived growth inhibitor (MDGI).
JD101506 - Sequence 82530 from Patent EP1572962.
JD299239 - Sequence 280263 from Patent EP1572962.
LF356812 - JP 2014500723-A/164315: Polycomb-Associated Non-Coding RNAs.
X56549 - Human mRNA for muscle fatty-acid-binding protein (FABP).
JD185745 - Sequence 166769 from Patent EP1572962.
JD059770 - Sequence 40794 from Patent EP1572962.
KJ891141 - Synthetic construct Homo sapiens clone ccsbBroadEn_00535 FABP3 gene, encodes complete protein.
AK314122 - Homo sapiens cDNA, FLJ94819, Homo sapiens fatty acid binding protein 3, muscle and heart(mammary-derived growth inhibitor) (FABP3), mRNA.
BT006727 - Homo sapiens fatty acid binding protein 3, muscle and heart (mammary-derived growth inhibitor) mRNA, complete cds.
DQ893154 - Synthetic construct clone IMAGE:100005784; FLH194402.01X; RZPDo839A1280D fatty acid binding protein 3, muscle and heart (mammary-derived growth inhibitor) (FABP3) gene, encodes complete protein.
DQ896449 - Synthetic construct Homo sapiens clone IMAGE:100010909; FLH194398.01L; RZPDo839A1270D fatty acid binding protein 3, muscle and heart (mammary-derived growth inhibitor) (FABP3) gene, encodes complete protein.
S67314 - heart fatty acid binding protein [human, heart, mRNA Partial, 357 nt].
CR456867 - Homo sapiens full open reading frame cDNA clone RZPDo834E0715D for gene FABP3, fatty acid binding protein 3, muscle and heart (mammary-derived growth inhibitor); complete cds, incl. stopcodon.
LF356809 - JP 2014500723-A/164312: Polycomb-Associated Non-Coding RNAs.
MA449460 - JP 2018138019-A/21386: Polycomb-Associated Non-Coding RNAs.
MA442217 - JP 2018138019-A/14143: Polycomb-Associated Non-Coding RNAs.
MA592389 - JP 2018138019-A/164315: Polycomb-Associated Non-Coding RNAs.
MA592386 - JP 2018138019-A/164312: Polycomb-Associated Non-Coding RNAs.

-  Biochemical and Signaling Pathways
  Reactome (by CSHL, EBI, and GO)

Protein P05413 (Reactome details) participates in the following event(s):

R-HSA-5334794 FABPs bind LCFAs
R-HSA-163560 Triglyceride catabolism
R-HSA-8979227 Triglyceride metabolism
R-HSA-556833 Metabolism of lipids
R-HSA-1430728 Metabolism

-  Other Names for This Gene
  Alternate Gene Symbols: B2RAB6, ENST00000373713.1, ENST00000373713.2, ENST00000373713.3, ENST00000373713.4, ENST00000373713.5, ENST00000373713.6, FABP11, FABPH_HUMAN, MDGI, NM_004102, P05413, Q5VV93, Q99957, uc318kzt.1, uc318kzt.2
UCSC ID: ENST00000373713.7_8
RefSeq Accession: NM_004102.5
Protein: P05413 (aka FABPH_HUMAN or FABH_HUMAN)

-  Gene Model Information
  Click here for a detailed description of the fields of the table above.

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.