Human Gene ATOSB (ENST00000322813.10_6) from GENCODE V47lift37
  Description: family with sequence similarity 214 member B, transcript variant 1 (from RefSeq NM_025182.4)
Gencode Transcript: ENST00000322813.10_6
Gencode Gene: ENSG00000005238.20_8
Transcript (Including UTRs)
   Position: hg19 chr9:35,104,114-35,115,859 Size: 11,746 Total Exon Count: 9 Strand: -
Coding Region
   Position: hg19 chr9:35,105,218-35,108,271 Size: 3,054 Coding Exon Count: 7 

Page IndexSequence and LinksUniProtKB CommentsPrimersGene AllelesRNA-Seq Expression
Microarray ExpressionRNA StructureProtein StructureOther SpeciesGO AnnotationsmRNA Descriptions
Other NamesModel InformationMethods
Data last updated at UCSC: 2024-08-22 23:36:26

-  Sequence and Links to Tools and Databases
 
Genomic Sequence (chr9:35,104,114-35,115,859)mRNA (may differ from genome)Protein (538 aa)
Gene SorterGenome BrowserOther Species FASTAVisiGeneTable SchemaAlphaFold
BioGPSEnsemblEntrez GeneExonPrimerGeneCardsMGI
PubMedUniProtKBBioGrid CRISPR DB

-  Comments and Description Text from UniProtKB
  ID: F214B_HUMAN
DESCRIPTION: RecName: Full=Protein FAM214B;
SIMILARITY: Belongs to the FAM214 family.
SEQUENCE CAUTION: Sequence=AAC07982.1; Type=Erroneous gene model prediction; Sequence=BAA96063.1; Type=Erroneous initiation; Note=Translation N-terminally shortened;

-  Primer design for this transcript
 

Primer3Plus can design qPCR Primers that straddle exon-exon-junctions, which amplify only cDNA, not genomic DNA.
Click here to load the transcript sequence and exon structure into Primer3Plus

Exonprimer can design one pair of Sanger sequencing primers around every exon, located in non-genic sequence.
Click here to open Exonprimer with this transcript

To design primers for a non-coding sequence, zoom to a region of interest and select from the drop-down menu: View > In External Tools > Primer3


+  Common Gene Haplotype Alleles
  Press "+" in the title bar above to open this section.

-  RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
  Highest median expression: 17.09 RPKM in Whole Blood
Total median expression: 287.67 RPKM



View in GTEx track of Genome Browser    View at GTEx portal     View GTEx Body Map

+  Microarray Expression Data
  Press "+" in the title bar above to open this section.

-  mRNA Secondary Structure of 3' and 5' UTRs
 
RegionFold EnergyBasesEnergy/Base
Display As
5' UTR -125.40277-0.453 Picture PostScript Text
3' UTR -374.501104-0.339 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Protein Domain and Structure Information
  InterPro Domains: Graphical view of domain structure
IPR025261 - DUF4210

Pfam Domains:
PF13889 - Chromosome segregation during meiosis
PF13915 - Domain of unknown function (DUF4210)

ModBase Predicted Comparative 3D Structure on Q7L5A3
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The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
MouseRatZebrafishD. melanogasterC. elegansS. cerevisiae
No orthologNo orthologNo orthologNo orthologNo orthologNo ortholog
Gene DetailsGene Details    
Gene SorterGene Sorter    
 RGD    
      
      

-  Gene Ontology (GO) Annotations with Structured Vocabulary
  Molecular Function:
GO:0005515 protein binding

Cellular Component:
GO:0005634 nucleus


-  Descriptions from all associated GenBank mRNAs
  LF206429 - JP 2014500723-A/13932: Polycomb-Associated Non-Coding RNAs.
AK022837 - Homo sapiens cDNA FLJ12775 fis, clone NT2RP2001677.
BC004406 - Homo sapiens KIAA1539, mRNA (cDNA clone MGC:10998 IMAGE:3638496), complete cds.
AB040972 - Homo sapiens KIAA1539 mRNA for KIAA1539 protein.
AL583909 - Homo sapiens mRNA; cDNA DKFZp761J197 (from clone DKFZp761J197).
AK021622 - Homo sapiens cDNA FLJ11560 fis, clone HEMBA1003133.
JD387593 - Sequence 368617 from Patent EP1572962.
JD320903 - Sequence 301927 from Patent EP1572962.
JD275899 - Sequence 256923 from Patent EP1572962.
JD275898 - Sequence 256922 from Patent EP1572962.
JD361269 - Sequence 342293 from Patent EP1572962.
JD309574 - Sequence 290598 from Patent EP1572962.
JD544524 - Sequence 525548 from Patent EP1572962.
JD188083 - Sequence 169107 from Patent EP1572962.
JD486801 - Sequence 467825 from Patent EP1572962.
LF354324 - JP 2014500723-A/161827: Polycomb-Associated Non-Coding RNAs.
JD226780 - Sequence 207804 from Patent EP1572962.
LF354325 - JP 2014500723-A/161828: Polycomb-Associated Non-Coding RNAs.
KJ894802 - Synthetic construct Homo sapiens clone ccsbBroadEn_04196 FAM214B gene, encodes complete protein.
AB463088 - Synthetic construct DNA, clone: pF1KA1539, Homo sapiens KIAA1539 gene, without stop codon, in Flexi system.
AM393037 - Synthetic construct Homo sapiens clone IMAGE:100001937 for hypothetical protein (KIAA1539 gene).
LF354326 - JP 2014500723-A/161829: Polycomb-Associated Non-Coding RNAs.
AK307682 - Homo sapiens cDNA, FLJ97630.
CU678712 - Synthetic construct Homo sapiens gateway clone IMAGE:100019815 5' read KIAA1539 mRNA.
JD335456 - Sequence 316480 from Patent EP1572962.
JD191020 - Sequence 172044 from Patent EP1572962.
JD056784 - Sequence 37808 from Patent EP1572962.
JD484385 - Sequence 465409 from Patent EP1572962.
LF354327 - JP 2014500723-A/161830: Polycomb-Associated Non-Coding RNAs.
JD452991 - Sequence 434015 from Patent EP1572962.
JD532603 - Sequence 513627 from Patent EP1572962.
JD090675 - Sequence 71699 from Patent EP1572962.
JD317648 - Sequence 298672 from Patent EP1572962.
MA442006 - JP 2018138019-A/13932: Polycomb-Associated Non-Coding RNAs.
MA589901 - JP 2018138019-A/161827: Polycomb-Associated Non-Coding RNAs.
MA589902 - JP 2018138019-A/161828: Polycomb-Associated Non-Coding RNAs.
MA589903 - JP 2018138019-A/161829: Polycomb-Associated Non-Coding RNAs.
MA589904 - JP 2018138019-A/161830: Polycomb-Associated Non-Coding RNAs.

-  Other Names for This Gene
  Alternate Gene Symbols: ATOSB , ATOSB_HUMAN, B1AML4, B1AML5, D3DRN5, ENST00000322813.1, ENST00000322813.2, ENST00000322813.3, ENST00000322813.4, ENST00000322813.5, ENST00000322813.6, ENST00000322813.7, ENST00000322813.8, ENST00000322813.9, FAM214B , KIAA1539 , NM_025182, O60377, Q7L5A3, Q9BQ60, Q9HAI9, Q9P1Y9, uc317rin.1, uc317rin.2
UCSC ID: ENST00000322813.10_6
RefSeq Accession: NM_025182.4
Protein: Q7L5A3 (aka F214B_HUMAN)

-  Gene Model Information
  Click here for a detailed description of the fields of the table above.

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.