Human Gene FBXL20 (ENST00000264658.11_10) from GENCODE V47lift37
Description: F-box and leucine rich repeat protein 20, transcript variant 1 (from RefSeq NM_032875.3)
Gencode Transcript: ENST00000264658.11_10
Gencode Gene: ENSG00000108306.13_20
Transcript (Including UTRs)
Position: hg19 chr17:37,408,916-37,557,879 Size: 148,964 Total Exon Count: 15 Strand: -
Coding Region
Position: hg19 chr17:37,417,713-37,557,655 Size: 139,943 Coding Exon Count: 15
Data last updated at UCSC: 2024-08-22 23:36:26
Sequence and Links to Tools and Databases
Comments and Description Text from UniProtKB
ID: FXL20_HUMAN
DESCRIPTION: RecName: Full=F-box/LRR-repeat protein 20; AltName: Full=F-box and leucine-rich repeat protein 20; AltName: Full=F-box/LRR-repeat protein 2-like;
FUNCTION: Substrate-recognition component of the SCF (SKP1-CUL1-F- box protein)-type E3 ubiquitin ligase complex. Role in neural transmission (By similarity).SUBUNIT: Interacts with SKP1 and CUL1 (By similarity).SUBCELLULAR LOCATION: Cytoplasm (By similarity).SIMILARITY: Contains 1 F-box domain.SIMILARITY: Contains 13 LRR (leucine-rich) repeats.
Primer design for this transcript
Comparative Toxicogenomics Database (CTD)
Common Gene Haplotype Alleles
Press "+" in the title bar above to open this section.
RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
Microarray Expression Data
Press "+" in the title bar above to open this section.
mRNA Secondary Structure of 3' and 5' UTRs
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
Protein Domain and Structure Information
InterPro Domains: Graphical view of domain structure IPR001810 - F-box_dom_cyclin-like
IPR006553 - Leu-rich_rpt_Cys-con_subtyp
Pfam Domains: PF00646 - F-box domain
PF12937 - F-box-like
PF13516 - Leucine Rich repeat
SCOP Domains: 81383 - F-box domain
46689 - Homeodomain-like
52047 - RNI-like
52058 - L domain-like
52075 - Outer arm dynein light chain 1
ModBase Predicted Comparative 3D Structure on Q96IG2
The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.
Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
Gene Ontology (GO) Annotations with Structured Vocabulary
Descriptions from all associated GenBank mRNAs
AK291844 - Homo sapiens cDNA FLJ78190 complete cds.BC007557 - Homo sapiens F-box and leucine-rich repeat protein 20, mRNA (cDNA clone MGC:15482 IMAGE:2987858), complete cds.DQ223959 - Homo sapiens F-box and leucine-rich repeat protein 20 variant b mRNA, complete cds, alternatively spliced.AK123048 - Homo sapiens cDNA FLJ41053 fis, clone SPLEN2002467, highly similar to F-box/LRR-repeat protein 20.AK312612 - Homo sapiens cDNA, FLJ92993, highly similar to Homo sapiens F-box and leucine-rich repeat protein 20 (FBXL20), mRNA.HQ447320 - Synthetic construct Homo sapiens clone IMAGE:100070636; CCSB005241_01 F-box and leucine-rich repeat protein 20 (FBXL20) gene, encodes complete protein.KJ895060 - Synthetic construct Homo sapiens clone ccsbBroadEn_04454 FBXL20 gene, encodes complete protein.CU675703 - Synthetic construct Homo sapiens gateway clone IMAGE:100019391 5' read FBXL20 mRNA.AL117623 - Homo sapiens mRNA; cDNA DKFZp564O2364 (from clone DKFZp564O2364).BC042012 - Homo sapiens hypothetical protein LOC90110, mRNA (cDNA clone IMAGE:5311439).JD343933 - Sequence 324957 from Patent EP1572962.JD320029 - Sequence 301053 from Patent EP1572962.JD094421 - Sequence 75445 from Patent EP1572962.JD411587 - Sequence 392611 from Patent EP1572962.JD552180 - Sequence 533204 from Patent EP1572962.JD137353 - Sequence 118377 from Patent EP1572962.JD391904 - Sequence 372928 from Patent EP1572962.JD399031 - Sequence 380055 from Patent EP1572962.JD485753 - Sequence 466777 from Patent EP1572962.JD548942 - Sequence 529966 from Patent EP1572962.JD119787 - Sequence 100811 from Patent EP1572962.JD516515 - Sequence 497539 from Patent EP1572962.JD482252 - Sequence 463276 from Patent EP1572962.JD237850 - Sequence 218874 from Patent EP1572962.JD056544 - Sequence 37568 from Patent EP1572962.JD551003 - Sequence 532027 from Patent EP1572962.JD448792 - Sequence 429816 from Patent EP1572962.JD117210 - Sequence 98234 from Patent EP1572962.JD482767 - Sequence 463791 from Patent EP1572962.JD290001 - Sequence 271025 from Patent EP1572962.JD183650 - Sequence 164674 from Patent EP1572962.JD053387 - Sequence 34411 from Patent EP1572962.JD564258 - Sequence 545282 from Patent EP1572962.JD564259 - Sequence 545283 from Patent EP1572962.JD564257 - Sequence 545281 from Patent EP1572962.JD175690 - Sequence 156714 from Patent EP1572962.JD446410 - Sequence 427434 from Patent EP1572962.DQ595079 - Homo sapiens piRNA piR-61191, complete sequence.JD321985 - Sequence 303009 from Patent EP1572962.JD103739 - Sequence 84763 from Patent EP1572962.JD346588 - Sequence 327612 from Patent EP1572962.JD312107 - Sequence 293131 from Patent EP1572962.JD346589 - Sequence 327613 from Patent EP1572962.JD312108 - Sequence 293132 from Patent EP1572962.JD346587 - Sequence 327611 from Patent EP1572962.JD312106 - Sequence 293130 from Patent EP1572962.JD264536 - Sequence 245560 from Patent EP1572962.JD151596 - Sequence 132620 from Patent EP1572962.JD290556 - Sequence 271580 from Patent EP1572962.JD160943 - Sequence 141967 from Patent EP1572962.JD153088 - Sequence 134112 from Patent EP1572962.JD198374 - Sequence 179398 from Patent EP1572962.JD272024 - Sequence 253048 from Patent EP1572962.DQ592857 - Homo sapiens piRNA piR-59969, complete sequence.AK024690 - Homo sapiens cDNA: FLJ21037 fis, clone CAE10055.JD209265 - Sequence 190289 from Patent EP1572962.JD216306 - Sequence 197330 from Patent EP1572962.JD277972 - Sequence 258996 from Patent EP1572962.JD550665 - Sequence 531689 from Patent EP1572962.JD489865 - Sequence 470889 from Patent EP1572962.JD341673 - Sequence 322697 from Patent EP1572962.JD378401 - Sequence 359425 from Patent EP1572962.JD188636 - Sequence 169660 from Patent EP1572962.JD511210 - Sequence 492234 from Patent EP1572962.JD058567 - Sequence 39591 from Patent EP1572962.JD242100 - Sequence 223124 from Patent EP1572962.JD343668 - Sequence 324692 from Patent EP1572962.JD289656 - Sequence 270680 from Patent EP1572962.JD460527 - Sequence 441551 from Patent EP1572962.JD458239 - Sequence 439263 from Patent EP1572962.JD126122 - Sequence 107146 from Patent EP1572962.JD476131 - Sequence 457155 from Patent EP1572962.
Biochemical and Signaling Pathways
Other Names for This Gene
Alternate Gene Symbols: A8K729, ENST00000264658.1, ENST00000264658.10, ENST00000264658.2, ENST00000264658.3, ENST00000264658.4, ENST00000264658.5, ENST00000264658.6, ENST00000264658.7, ENST00000264658.8, ENST00000264658.9, FBL2, FXL20_HUMAN, NM_032875, Q38J52, Q96IG2, uc317hub.1, uc317hub.2UCSC ID: ENST00000264658.11_10RefSeq Accession: NM_032875.3
Protein: Q96IG2
(aka FXL20_HUMAN or FXLK_HUMAN)
Gene Model Information
Click here
for a detailed description of the fields of the table above.
Methods, Credits, and Use Restrictions
Click here
for details on how this gene model was made and data restrictions if any.