ID:FOXJ1_HUMAN DESCRIPTION: RecName: Full=Forkhead box protein J1; AltName: Full=Forkhead-related protein FKHL13; AltName: Full=Hepatocyte nuclear factor 3 forkhead homolog 4; Short=HFH-4; FUNCTION: May play an important role in cell fate determination during lung development and in spermatogenesis (By similarity). SUBCELLULAR LOCATION: Nucleus. TISSUE SPECIFICITY: Testis, oviduct, lung and brain cortex. DEVELOPMENTAL STAGE: Expressed in developing lung, kidney and central nervous system. DISEASE: Genetic variations in FOXJ1 may be associated with susceptibility to allergic rhinitis (ALRH) [MIM:607154]. Allergic rhinitis is a common disease of complex inheritance and is characterized by mucosal inflammation caused by allergen exposure. SIMILARITY: Contains 1 fork-head DNA-binding domain.
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
ModBase Predicted Comparative 3D Structure on Q92949
Front
Top
Side
The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.
Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
Gene Ontology (GO) Annotations with Structured Vocabulary
Molecular Function: GO:0000976 transcription regulatory region sequence-specific DNA binding GO:0000978 RNA polymerase II core promoter proximal region sequence-specific DNA binding GO:0000981 RNA polymerase II transcription factor activity, sequence-specific DNA binding GO:0001077 transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding GO:0003677 DNA binding GO:0003700 transcription factor activity, sequence-specific DNA binding GO:0005515 protein binding GO:0043565 sequence-specific DNA binding
Biological Process: GO:0000122 negative regulation of transcription from RNA polymerase II promoter GO:0002508 central tolerance induction GO:0002635 negative regulation of germinal center formation GO:0002897 positive regulation of central B cell tolerance induction GO:0002924 negative regulation of humoral immune response mediated by circulating immunoglobulin GO:0006351 transcription, DNA-templated GO:0006355 regulation of transcription, DNA-templated GO:0006366 transcription from RNA polymerase II promoter GO:0006959 humoral immune response GO:0007283 spermatogenesis GO:0007368 determination of left/right symmetry GO:0007389 pattern specification process GO:0007420 brain development GO:0007507 heart development GO:0030030 cell projection organization GO:0030036 actin cytoskeleton organization GO:0030856 regulation of epithelial cell differentiation GO:0032088 negative regulation of NF-kappaB transcription factor activity GO:0033085 negative regulation of T cell differentiation in thymus GO:0035089 establishment of apical/basal cell polarity GO:0035502 metanephric part of ureteric bud development GO:0042130 negative regulation of T cell proliferation GO:0044458 motile cilium assembly GO:0045409 negative regulation of interleukin-6 biosynthetic process GO:0045944 positive regulation of transcription from RNA polymerase II promoter GO:0050869 negative regulation of B cell activation GO:0050900 leukocyte migration GO:0060271 cilium assembly GO:0060428 lung epithelium development GO:0060429 epithelium development GO:0060972 left/right pattern formation GO:0072016 glomerular parietal epithelial cell development GO:0090630 activation of GTPase activity GO:1901248 positive regulation of lung ciliated cell differentiation
US Server
Sequence and Links to Tools and Databases 
Common Gene Haplotype Alleles 
