ID:GAS2_HUMAN DESCRIPTION: RecName: Full=Growth arrest-specific protein 2; Short=GAS-2; FUNCTION: May play a role in apoptosis by acting as a cell death substrate for caspases. Is cleaved during apoptosis and the cleaved form induces dramatic rearrangements of the actin cytoskeleton and potent changes in the shape of the affected cells. May be involved in the membrane ruffling process (By similarity). SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton (By similarity). Membrane; Peripheral membrane protein (By similarity). Note=Component of the microfilament system. Colocalizes with actin fibers at the cell border and along the stress fibers in growth- arrested fibroblasts. Mainly membrane-associated. When hyperphosphorylated, accumulates at membrane ruffles (By similarity). TISSUE SPECIFICITY: Ubiquitously expressed with highest levels in liver, lung, and kidney. Not found in spleen. DEVELOPMENTAL STAGE: Specifically expressed at growth arrest. PTM: Cleaved, during apoptosis, on a specific aspartic residue by caspases. PTM: Phosphorylated on serine residues during the G0-G1 transition phase (By similarity). SIMILARITY: Belongs to the GAS2 family. SIMILARITY: Contains 1 CH (calponin-homology) domain. SIMILARITY: Contains 1 GAR domain.
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
ModBase Predicted Comparative 3D Structure on O43903
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
US Server
Sequence and Links to Tools and Databases 
Common Gene Haplotype Alleles 
