Human Gene GFOD1 (ENST00000379287.4_7) from GENCODE V47lift37

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Description: glucose-fructose oxidoreductase domain containing 1, transcript variant 1 (from RefSeq NM_018988.4)
Gencode Transcript: ENST00000379287.4_7
Gencode Gene: ENSG00000145990.11_9
Transcript (Including UTRs)
Position: hg19 chr6:13,358,062-13,487,832 Size: 129,771 Total Exon Count: 2 Strand: -
Coding Region
Position: hg19 chr6:13,364,975-13,487,122 Size: 122,148 Coding Exon Count: 2

Page Index	Sequence and Links	UniProtKB Comments	Primers	MalaCards	CTD
Gene Alleles	RNA-Seq Expression	Microarray Expression	RNA Structure	Protein Structure	Other Species
GO Annotations	mRNA Descriptions	Other Names	Model Information	Methods

Data last updated at UCSC: 2024-08-22 23:36:26

Sequence and Links to Tools and Databases

Genomic Sequence (chr6:13,358,062-13,487,832)			mRNA (may differ from genome)		Protein (390 aa)
Gene Sorter	Genome Browser	Other Species FASTA	VisiGene	Gene interactions	Table Schema
AlphaFold	BioGPS	Ensembl	Entrez Gene	ExonPrimer	GeneCards
HGNC	Malacards	MGI	PubMed	UniProtKB	BioGrid CRISPR DB

Comments and Description Text from UniProtKB


	ID: GFOD1_HUMAN DESCRIPTION: RecName: Full=Glucose-fructose oxidoreductase domain-containing protein 1; EC=1.-.-.-; Flags: Precursor; SUBCELLULAR LOCATION: Secreted (Potential). SIMILARITY: Belongs to the Gfo/Idh/MocA family.

Primer design for this transcript

Primer3Plus can design qPCR Primers that straddle exon-exon-junctions, which amplify only cDNA, not genomic DNA.
Click here to load the transcript sequence and exon structure into Primer3Plus

Exonprimer can design one pair of Sanger sequencing primers around every exon, located in non-genic sequence.
Click here to open Exonprimer with this transcript

To design primers for a non-coding sequence, zoom to a region of interest and select from the drop-down menu: View > In External Tools > Primer3

MalaCards Disease Associations


	MalaCards Gene Search: GFOD1 Diseases sorted by gene-association score: attention deficit-hyperactivity disorder (2)

Comparative Toxicogenomics Database (CTD)


	The following chemicals interact with this gene C548651 2-(1'H-indolo-3'-carbonyl)thiazole-4-carboxylic acid methyl ester D000082 Acetaminophen D000535 Aluminum D000638 Amiodarone D001564 Benzo(a)pyrene D002737 Chloroprene D002794 Choline D016572 Cyclosporine D004041 Dietary Fats D005492 Folic Acid more ... click here to view the complete list

Common Gene Haplotype Alleles


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RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)


	Highest median expression: 17.07 RPKM in Brain - Cerebellum Total median expression: 241.48 RPKM View in GTEx track of Genome Browser View at GTEx portal View GTEx Body Map

Microarray Expression Data


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mRNA Secondary Structure of 3' and 5' UTRs

Region	Fold Energy	Bases	Energy/Base	Display As
5' UTR	-395.20	710	-0.557	Picture	PostScript	Text
3' UTR	-2253.00	6913	-0.326	Picture	PostScript	Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

Protein Domain and Structure Information

InterPro Domains: Graphical view of domain structure
IPR016040 - NAD(P)-bd_dom
IPR000683 - Oxidoreductase_N
IPR004104 - OxRdtase_C

Pfam Domains:
PF01408 - Oxidoreductase family, NAD-binding Rossmann fold
PF02894 - Oxidoreductase family, C-terminal alpha/beta domain

SCOP Domains:
51735 - NAD(P)-binding Rossmann-fold domains
55347 - Glyceraldehyde-3-phosphate dehydrogenase-like, C-terminal domain

ModBase Predicted Comparative 3D Structure on Q9NXC2


Front	Top	Side

The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

Orthologous Genes in Other Species

Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.

Mouse	Rat	Zebrafish	D. melanogaster	C. elegans	S. cerevisiae
No ortholog	No ortholog	No ortholog	No ortholog	No ortholog	No ortholog
Gene Details	Gene Details
Gene Sorter	Gene Sorter
	RGD	Ensembl

Gene Ontology (GO) Annotations with Structured Vocabulary


	Molecular Function: GO:0005515 protein binding GO:0016491 oxidoreductase activity Biological Process: GO:0008152 metabolic process GO:0055114 oxidation-reduction process Cellular Component: GO:0005576 extracellular region

Descriptions from all associated GenBank mRNAs


	AK027010 - Homo sapiens cDNA: FLJ23357 fis, clone HEP14975. AK000337 - Homo sapiens cDNA FLJ20330 fis, clone HEP10296. BC119005 - Homo sapiens glucose-fructose oxidoreductase domain containing 1, mRNA (cDNA clone MGC:141915 IMAGE:40085551), complete cds. BC124557 - Homo sapiens glucose-fructose oxidoreductase domain containing 1, mRNA (cDNA clone MGC:141916 IMAGE:40085552), complete cds. AK055131 - Homo sapiens cDNA FLJ30569 fis, clone BRAWH2005974, weakly similar to Oxidoreductase. BC148295 - Homo sapiens glucose-fructose oxidoreductase domain containing 1, mRNA (cDNA clone MGC:171159 IMAGE:40122213), complete cds. KJ894021 - Synthetic construct Homo sapiens clone ccsbBroadEn_03415 GFOD1 gene, encodes complete protein. BC045745 - Homo sapiens cDNA clone IMAGE:5263441. BC029596 - Homo sapiens cDNA clone IMAGE:5277718. AK123914 - Homo sapiens cDNA FLJ41920 fis, clone PERIC2002452. AL831898 - Homo sapiens mRNA; cDNA DKFZp547P158 (from clone DKFZp547P158). JD414288 - Sequence 395312 from Patent EP1572962. JD462987 - Sequence 444011 from Patent EP1572962. AK127555 - Homo sapiens cDNA FLJ45648 fis, clone CTONG2009033. JD552605 - Sequence 533629 from Patent EP1572962. JD384565 - Sequence 365589 from Patent EP1572962. JD201617 - Sequence 182641 from Patent EP1572962. JD513977 - Sequence 495001 from Patent EP1572962. JD159549 - Sequence 140573 from Patent EP1572962. JD355545 - Sequence 336569 from Patent EP1572962. JD061097 - Sequence 42121 from Patent EP1572962. JD215467 - Sequence 196491 from Patent EP1572962. JD165011 - Sequence 146035 from Patent EP1572962. JD525128 - Sequence 506152 from Patent EP1572962. JD129265 - Sequence 110289 from Patent EP1572962. JD496385 - Sequence 477409 from Patent EP1572962. JD215499 - Sequence 196523 from Patent EP1572962. JD501907 - Sequence 482931 from Patent EP1572962. JD248254 - Sequence 229278 from Patent EP1572962. JD145941 - Sequence 126965 from Patent EP1572962. JD197949 - Sequence 178973 from Patent EP1572962. JD212551 - Sequence 193575 from Patent EP1572962. JD487964 - Sequence 468988 from Patent EP1572962. JD503864 - Sequence 484888 from Patent EP1572962. JD438264 - Sequence 419288 from Patent EP1572962. JD504837 - Sequence 485861 from Patent EP1572962. JD207533 - Sequence 188557 from Patent EP1572962. JD345563 - Sequence 326587 from Patent EP1572962. JD337516 - Sequence 318540 from Patent EP1572962. JD371241 - Sequence 352265 from Patent EP1572962. JD514406 - Sequence 495430 from Patent EP1572962. JD524672 - Sequence 505696 from Patent EP1572962. JD352447 - Sequence 333471 from Patent EP1572962. JD265905 - Sequence 246929 from Patent EP1572962. JD063901 - Sequence 44925 from Patent EP1572962. JD530588 - Sequence 511612 from Patent EP1572962. JD422726 - Sequence 403750 from Patent EP1572962. JD078251 - Sequence 59275 from Patent EP1572962. JD154094 - Sequence 135118 from Patent EP1572962. JD058117 - Sequence 39141 from Patent EP1572962. JD509526 - Sequence 490550 from Patent EP1572962. JD449340 - Sequence 430364 from Patent EP1572962. JD074133 - Sequence 55157 from Patent EP1572962. JD565738 - Sequence 546762 from Patent EP1572962. JD443588 - Sequence 424612 from Patent EP1572962. JD080907 - Sequence 61931 from Patent EP1572962. JD130024 - Sequence 111048 from Patent EP1572962. JD356849 - Sequence 337873 from Patent EP1572962. JD323165 - Sequence 304189 from Patent EP1572962. JD213706 - Sequence 194730 from Patent EP1572962. JD348034 - Sequence 329058 from Patent EP1572962. JD466584 - Sequence 447608 from Patent EP1572962. JD403306 - Sequence 384330 from Patent EP1572962. JD085707 - Sequence 66731 from Patent EP1572962. JD044501 - Sequence 25525 from Patent EP1572962. JD423987 - Sequence 405011 from Patent EP1572962. JD235317 - Sequence 216341 from Patent EP1572962. JD206782 - Sequence 187806 from Patent EP1572962. JD482162 - Sequence 463186 from Patent EP1572962. JD278928 - Sequence 259952 from Patent EP1572962. JD214802 - Sequence 195826 from Patent EP1572962. JD483728 - Sequence 464752 from Patent EP1572962. JD458134 - Sequence 439158 from Patent EP1572962. JD076676 - Sequence 57700 from Patent EP1572962. DQ590477 - Homo sapiens piRNA piR-57589, complete sequence. JD540024 - Sequence 521048 from Patent EP1572962. JD336878 - Sequence 317902 from Patent EP1572962. JD066741 - Sequence 47765 from Patent EP1572962. JD129896 - Sequence 110920 from Patent EP1572962. JD215647 - Sequence 196671 from Patent EP1572962. JD337331 - Sequence 318355 from Patent EP1572962. JD444111 - Sequence 425135 from Patent EP1572962.

Other Names for This Gene


	Alternate Gene Symbols: A8E4L6, C6orf114, ENST00000379287.1, ENST00000379287.2, ENST00000379287.3, GFOD1_HUMAN, NM_018988, Q5T058, Q96JD4, Q9H5K2, Q9NXC2, uc318owj.1, uc318owj.2 UCSC ID: ENST00000379287.4_7 RefSeq Accession: NM_018988.4 Protein: Q9NXC2 (aka GFOD1_HUMAN)

Gene Model Information


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Methods, Credits, and Use Restrictions


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