ID:GOGA4_HUMAN DESCRIPTION: RecName: Full=Golgin subfamily A member 4; AltName: Full=256 kDa golgin; AltName: Full=Golgin-245; AltName: Full=Protein 72.1; AltName: Full=Trans-Golgi p230; FUNCTION: May play a role in delivery of transport vesicles containing GPI-linked proteins from the trans-Golgi network through its interaction with MACF1. SUBUNIT: Homodimer. Interacts with GTP bound ARL1. Interacts with MACF1. INTERACTION: Q96NW4:ANKRD27; NbExp=2; IntAct=EBI-1037845, EBI-6125599; SUBCELLULAR LOCATION: Cytoplasm. Golgi apparatus membrane; Peripheral membrane protein. Golgi apparatus. DOMAIN: Extended rod-like protein with coiled-coil domains. MISCELLANEOUS: Antibodies against GOLGA4 are present in sera from patients with Sjoegren syndrome. Sera from patients with Sjoegren syndrome often contain antibodies that react with normal components of the Golgi complex. SIMILARITY: Contains 1 GRIP domain. SEQUENCE CAUTION: Sequence=CAA58041.1; Type=Frameshift; Positions=2153;
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
ModBase Predicted Comparative 3D Structure on Q13439
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
Biological Process: GO:0016192 vesicle-mediated transport GO:0043001 Golgi to plasma membrane protein transport GO:0045773 positive regulation of axon extension
BC045543 - Homo sapiens golgi autoantigen, golgin subfamily a, 4, mRNA (cDNA clone IMAGE:4825929), complete cds. BC050444 - Homo sapiens golgi autoantigen, golgin subfamily a, 4, mRNA (cDNA clone IMAGE:6500360), complete cds. AK290550 - Homo sapiens cDNA FLJ77065 partial cds, highly similar to Homo sapiens golgi autoantigen, golgin subfamily a, 4 (GOLGA4), mRNA. BC023648 - Homo sapiens golgi autoantigen, golgin subfamily a, 4, mRNA (cDNA clone IMAGE:3959585), partial cds. AK300192 - Homo sapiens cDNA FLJ54338 partial cds, highly similar to Golgin subfamily A member 4. AK307429 - Homo sapiens cDNA, FLJ97377. AB209693 - Homo sapiens mRNA for golgi autoantigen, golgin subfamily a, 4 variant protein. U41740 - Human trans-Golgi p230 mRNA, complete cds. X82834 - H.sapiens mRNA for golgin. BC172405 - Synthetic construct Homo sapiens clone IMAGE:100069099, MGC:199110 golgi autoantigen, golgin subfamily a, 4 (GOLGA4) mRNA, encodes complete protein. CU690684 - Synthetic construct Homo sapiens gateway clone IMAGE:100022740 5' read GOLGA4 mRNA. KJ901460 - Synthetic construct Homo sapiens clone ccsbBroadEn_10854 GOLGA4 gene, encodes complete protein. U31906 - Homo sapiens golgin-245 mRNA, complete cds. AF273047 - Homo sapiens CTCL tumor antigen se20-7 mRNA, partial cds. JD232532 - Sequence 213556 from Patent EP1572962. JD210320 - Sequence 191344 from Patent EP1572962. X76942 - H.sapiens mRNA for 72.1 protein. JD130585 - Sequence 111609 from Patent EP1572962. JD557208 - Sequence 538232 from Patent EP1572962. JD436686 - Sequence 417710 from Patent EP1572962. JD038013 - Sequence 19037 from Patent EP1572962. JD286385 - Sequence 267409 from Patent EP1572962. JD486260 - Sequence 467284 from Patent EP1572962. AY531221 - Homo sapiens antigen MU-RMS-40.18 mRNA, partial cds. KJ818093 - Homo sapiens centrosome-related protein F46 (CRPF46) mRNA, partial cds. BX640663 - Homo sapiens mRNA; cDNA DKFZp686K22142 (from clone DKFZp686K22142). JD454160 - Sequence 435184 from Patent EP1572962. JD465672 - Sequence 446696 from Patent EP1572962. JD546945 - Sequence 527969 from Patent EP1572962. JD037998 - Sequence 19022 from Patent EP1572962. JD267720 - Sequence 248744 from Patent EP1572962. JD502617 - Sequence 483641 from Patent EP1572962. JD093223 - Sequence 74247 from Patent EP1572962.
Biochemical and Signaling Pathways
Reactome (by CSHL, EBI, and GO)
Protein Q13439 (Reactome details) participates in the following event(s):
R-HSA-6814091 ARL1 recruits TGN Golgin homodimers R-HSA-6811431 RAB6:GTP binds the GARP and COG complexes, t-SNAREs and endosome-derived vesicles R-HSA-6811440 Retrograde transport at the Trans-Golgi-Network R-HSA-6811442 Intra-Golgi and retrograde Golgi-to-ER traffic R-HSA-199991 Membrane Trafficking R-HSA-5653656 Vesicle-mediated transport
US Server
Sequence and Links to Tools and Databases 
Common Gene Haplotype Alleles 
