Human Gene GOLGA4 (ENST00000361924.7_8) from GENCODE V47lift37

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Description: golgin A4, transcript variant 2 (from RefSeq NM_002078.5)
Gencode Transcript: ENST00000361924.7_8
Gencode Gene: ENSG00000144674.19_17
Transcript (Including UTRs)
Position: hg19 chr3:37,284,762-37,408,370 Size: 123,609 Total Exon Count: 24 Strand: +
Coding Region
Position: hg19 chr3:37,285,042-37,402,763 Size: 117,722 Coding Exon Count: 23

Page Index	Sequence and Links	UniProtKB Comments	Primers	CTD	Gene Alleles
RNA-Seq Expression	Microarray Expression	RNA Structure	Protein Structure	Other Species	GO Annotations
mRNA Descriptions	Pathways	Other Names	Model Information	Methods

Data last updated at UCSC: 2024-08-22 23:36:26

Sequence and Links to Tools and Databases

Genomic Sequence (chr3:37,284,762-37,408,370)			mRNA (may differ from genome)		Protein (2230 aa)
Gene Sorter	Genome Browser	Other Species FASTA	VisiGene	Gene interactions	Table Schema
AlphaFold	BioGPS	Ensembl	Entrez Gene	ExonPrimer	GeneCards
HGNC	MGI	OMIM	PubMed	Reactome	UniProtKB
Wikipedia	BioGrid CRISPR DB

Comments and Description Text from UniProtKB


	ID: GOGA4_HUMAN DESCRIPTION: RecName: Full=Golgin subfamily A member 4; AltName: Full=256 kDa golgin; AltName: Full=Golgin-245; AltName: Full=Protein 72.1; AltName: Full=Trans-Golgi p230; FUNCTION: May play a role in delivery of transport vesicles containing GPI-linked proteins from the trans-Golgi network through its interaction with MACF1. SUBUNIT: Homodimer. Interacts with GTP bound ARL1. Interacts with MACF1. INTERACTION: Q96NW4:ANKRD27; NbExp=2; IntAct=EBI-1037845, EBI-6125599; SUBCELLULAR LOCATION: Cytoplasm. Golgi apparatus membrane; Peripheral membrane protein. Golgi apparatus. DOMAIN: Extended rod-like protein with coiled-coil domains. MISCELLANEOUS: Antibodies against GOLGA4 are present in sera from patients with Sjoegren syndrome. Sera from patients with Sjoegren syndrome often contain antibodies that react with normal components of the Golgi complex. SIMILARITY: Contains 1 GRIP domain. SEQUENCE CAUTION: Sequence=CAA58041.1; Type=Frameshift; Positions=2153;

Primer design for this transcript

Primer3Plus can design qPCR Primers that straddle exon-exon-junctions, which amplify only cDNA, not genomic DNA.
Click here to load the transcript sequence and exon structure into Primer3Plus

Exonprimer can design one pair of Sanger sequencing primers around every exon, located in non-genic sequence.
Click here to open Exonprimer with this transcript

To design primers for a non-coding sequence, zoom to a region of interest and select from the drop-down menu: View > In External Tools > Primer3

Comparative Toxicogenomics Database (CTD)


	The following chemicals interact with this gene D001151 Arsenic D002945 Cisplatin C032668 1-nitropyrene C049584 2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine C030370 2-methoxy-5-(2',3',4'-trimethoxyphenyl)tropone C009505 4,4'-diaminodiphenylmethane D015123 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide D000082 Acetaminophen D016604 Aflatoxin B1 D001564 Benzo(a)pyrene D002330 Carmustine D003010 Clorgyline D019327 Copper Sulfate D016572 Cyclosporine D004317 Doxorubicin D004997 Ethinyl Estradiol D006861 Hydrogen Peroxide D058185 Magnetite Nanoparticles D008464 Mecamylamine D009538 Nicotine D010634 Phenobarbital D012402 Rotenone D004113 Succimer D013749 Tetrachlorodibenzodioxin D014403 Tubocurarine C025154 alpha-cobratoxin C482199 lipopolysaccharide, E coli O55-B5 C086401 pentabromodiphenyl ether C009277 sodium arsenate C004648 testosterone enanthate C080163 trovafloxacin

Common Gene Haplotype Alleles


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RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)


	Highest median expression: 23.66 RPKM in Muscle - Skeletal Total median expression: 573.50 RPKM View in GTEx track of Genome Browser View at GTEx portal View GTEx Body Map

Microarray Expression Data


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mRNA Secondary Structure of 3' and 5' UTRs

Region	Fold Energy	Bases	Energy/Base	Display As
5' UTR	-129.30	280	-0.462	Picture	PostScript	Text
3' UTR	-181.10	833	-0.217	Picture	PostScript	Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

Protein Domain and Structure Information

InterPro Domains: Graphical view of domain structure
IPR000237 - GRIP

Pfam Domains:
PF01465 - GRIP domain

SCOP Domains:
101283 - GRIP domain

Protein Data Bank (PDB) 3-D Structure
MuPIT help

1R4A - X-ray MuPIT

1UPT - X-ray

ModBase Predicted Comparative 3D Structure on Q13439


Front	Top	Side

The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

Orthologous Genes in Other Species

Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.

Mouse	Rat	Zebrafish	D. melanogaster	C. elegans	S. cerevisiae
No ortholog	No ortholog	No ortholog	No ortholog	No ortholog	No ortholog
Gene Details	Gene Details
Gene Sorter	Gene Sorter
	RGD	Ensembl

Gene Ontology (GO) Annotations with Structured Vocabulary


	Molecular Function: GO:0005515 protein binding GO:0051020 GTPase binding Biological Process: GO:0016192 vesicle-mediated transport GO:0043001 Golgi to plasma membrane protein transport GO:0045773 positive regulation of axon extension Cellular Component: GO:0000139 Golgi membrane GO:0005737 cytoplasm GO:0005794 Golgi apparatus GO:0005802 trans-Golgi network GO:0005829 cytosol GO:0016020 membrane GO:0043231 intracellular membrane-bounded organelle GO:0070062 extracellular exosome

Descriptions from all associated GenBank mRNAs


	BC045543 - Homo sapiens golgi autoantigen, golgin subfamily a, 4, mRNA (cDNA clone IMAGE:4825929), complete cds. BC050444 - Homo sapiens golgi autoantigen, golgin subfamily a, 4, mRNA (cDNA clone IMAGE:6500360), complete cds. AK290550 - Homo sapiens cDNA FLJ77065 partial cds, highly similar to Homo sapiens golgi autoantigen, golgin subfamily a, 4 (GOLGA4), mRNA. BC023648 - Homo sapiens golgi autoantigen, golgin subfamily a, 4, mRNA (cDNA clone IMAGE:3959585), partial cds. AK300192 - Homo sapiens cDNA FLJ54338 partial cds, highly similar to Golgin subfamily A member 4. AK307429 - Homo sapiens cDNA, FLJ97377. AB209693 - Homo sapiens mRNA for golgi autoantigen, golgin subfamily a, 4 variant protein. U41740 - Human trans-Golgi p230 mRNA, complete cds. X82834 - H.sapiens mRNA for golgin. BC172405 - Synthetic construct Homo sapiens clone IMAGE:100069099, MGC:199110 golgi autoantigen, golgin subfamily a, 4 (GOLGA4) mRNA, encodes complete protein. CU690684 - Synthetic construct Homo sapiens gateway clone IMAGE:100022740 5' read GOLGA4 mRNA. KJ901460 - Synthetic construct Homo sapiens clone ccsbBroadEn_10854 GOLGA4 gene, encodes complete protein. U31906 - Homo sapiens golgin-245 mRNA, complete cds. AF273047 - Homo sapiens CTCL tumor antigen se20-7 mRNA, partial cds. JD232532 - Sequence 213556 from Patent EP1572962. JD210320 - Sequence 191344 from Patent EP1572962. X76942 - H.sapiens mRNA for 72.1 protein. JD130585 - Sequence 111609 from Patent EP1572962. JD557208 - Sequence 538232 from Patent EP1572962. JD436686 - Sequence 417710 from Patent EP1572962. JD038013 - Sequence 19037 from Patent EP1572962. JD286385 - Sequence 267409 from Patent EP1572962. JD486260 - Sequence 467284 from Patent EP1572962. AY531221 - Homo sapiens antigen MU-RMS-40.18 mRNA, partial cds. KJ818093 - Homo sapiens centrosome-related protein F46 (CRPF46) mRNA, partial cds. BX640663 - Homo sapiens mRNA; cDNA DKFZp686K22142 (from clone DKFZp686K22142). JD454160 - Sequence 435184 from Patent EP1572962. JD465672 - Sequence 446696 from Patent EP1572962. JD546945 - Sequence 527969 from Patent EP1572962. JD037998 - Sequence 19022 from Patent EP1572962. JD267720 - Sequence 248744 from Patent EP1572962. JD502617 - Sequence 483641 from Patent EP1572962. JD093223 - Sequence 74247 from Patent EP1572962.

Biochemical and Signaling Pathways


	Reactome (by CSHL, EBI, and GO) Protein Q13439 (Reactome details) participates in the following event(s): R-HSA-6814091 ARL1 recruits TGN Golgin homodimers R-HSA-6811431 RAB6:GTP binds the GARP and COG complexes, t-SNAREs and endosome-derived vesicles R-HSA-6811440 Retrograde transport at the Trans-Golgi-Network R-HSA-6811442 Intra-Golgi and retrograde Golgi-to-ER traffic R-HSA-199991 Membrane Trafficking R-HSA-5653656 Vesicle-mediated transport

Other Names for This Gene


	Alternate Gene Symbols: ENST00000361924.1, ENST00000361924.2, ENST00000361924.3, ENST00000361924.4, ENST00000361924.5, ENST00000361924.6, F8W8Q7, GOGA4_HUMAN, NM_002078, Q13270, Q13439, Q13654, Q14436, Q59EW8, uc318ckt.1, uc318ckt.2 UCSC ID: ENST00000361924.7_8 RefSeq Accession: NM_002078.5 Protein: Q13439 (aka GOGA4_HUMAN or GOA4_HUMAN)

Gene Model Information


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Methods, Credits, and Use Restrictions


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