ID:GOGA5_HUMAN DESCRIPTION: RecName: Full=Golgin subfamily A member 5; AltName: Full=Cell proliferation-inducing gene 31 protein; AltName: Full=Golgin-84; AltName: Full=Protein Ret-II; AltName: Full=RET-fused gene 5 protein; FUNCTION: Involved in maintaining Golgi structure. Stimulates the formation of Golgi stacks and ribbons. Involved in intra-Golgi retrograde transport. SUBUNIT: Homodimer. Interacts with RAB1A that has been activated by GTP-binding, and possibly also with OCRL1. Interacts with isoform CASP of CUX1. SUBCELLULAR LOCATION: Golgi apparatus membrane; Single-pass type IV membrane protein. Note=Found throughout the Golgi, both on cisternae and, at higher abundance, on the tubulo-vesicular structures of the cis-Golgi network. TISSUE SPECIFICITY: Ubiquitous. Highly expressed in seminiferous tubules and Leydig cells in testis, and detected at much lower levels in the other tissues tested. Expression is very low or not detectable in spermatozoa. PTM: Highly phosphorylated during mitosis. Phosphorylation is barely detectable during interphase. DISEASE: Defects in GOLGA5 are a cause of thyroid papillary carcinoma (TPC) [MIM:188550]. TPC is a common tumor of the thyroid that typically arises as an irregular, solid or cystic mass from otherwise normal thyroid tissue. Papillary carcinomas are malignant neoplasm characterized by the formation of numerous, irregular, finger-like projections of fibrous stroma that is covered with a surface layer of neoplastic epithelial cells. Note=A chromosomal aberration involving GOLGA5 is found in thyroid papillary carcinomas. Translocation t(10;14)(q11;q32) with RET. The translocation generates the RET/GOLGA5 (PTC5) oncogene which was found in 2 cases of PACT in children exposed to radioactive fallout after Chernobyl. SEQUENCE CAUTION: Sequence=CAA33787.1; Type=Miscellaneous discrepancy; Note=Chimeric cDNA. A chimeric cDNA originating from chromosomes 14 and 10;
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
Pfam Domains: PF09787 - Golgin subfamily A member 5
SCOP Domains: 68906 - SAP domain 57997 - Tropomyosin
ModBase Predicted Comparative 3D Structure on Q8TBA6
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
BC023021 - Homo sapiens golgi autoantigen, golgin subfamily a, 5, mRNA (cDNA clone MGC:29870 IMAGE:4999710), complete cds. AK303789 - Homo sapiens cDNA FLJ54399 complete cds, highly similar to Golgin subfamily A member 5. AK293077 - Homo sapiens cDNA FLJ76981 complete cds, highly similar to Homo sapiens golgi autoantigen, golgin subfamily a, 5 (GOLGA5), mRNA. BC010134 - Homo sapiens cDNA clone IMAGE:3958596, containing frame-shift errors. AF085199 - Homo sapiens golgin-84 mRNA, complete cds. JD240752 - Sequence 221776 from Patent EP1572962. JD462491 - Sequence 443515 from Patent EP1572962. AY644768 - Homo sapiens cell proliferation-inducing gene 31 mRNA, complete cds. X15786 - Human ret-II gene. JD349264 - Sequence 330288 from Patent EP1572962. AJ132949 - Homo sapiens mRNA for rfg5 protein. BX248744 - human full-length cDNA 3-PRIME end of clone CL0BB014ZG01 of Neuroblastoma of Homo sapiens (human). JD116452 - Sequence 97476 from Patent EP1572962. JD048550 - Sequence 29574 from Patent EP1572962. JD235108 - Sequence 216132 from Patent EP1572962. JD563815 - Sequence 544839 from Patent EP1572962. JD084254 - Sequence 65278 from Patent EP1572962. JD358255 - Sequence 339279 from Patent EP1572962. JD223239 - Sequence 204263 from Patent EP1572962. JD552654 - Sequence 533678 from Patent EP1572962. JD506104 - Sequence 487128 from Patent EP1572962.
Biochemical and Signaling Pathways
Reactome (by CSHL, EBI, and GO)
Protein Q8TBA6 (Reactome details) participates in the following event(s):
R-HSA-8847544 The COG complex and CUX1 and GOLGA5 dimers contribute to intra-Golgi vesicle tethering R-HSA-6811438 Intra-Golgi traffic R-HSA-6811442 Intra-Golgi and retrograde Golgi-to-ER traffic R-HSA-199991 Membrane Trafficking R-HSA-5653656 Vesicle-mediated transport
US Server
Sequence and Links to Tools and Databases 
Common Gene Haplotype Alleles 
