Human Gene GPBP1L1 (ENST00000290795.7_7) from GENCODE V47lift37

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Description: Possible transcription factor. (from UniProt Q9HC44)
Gencode Transcript: ENST00000290795.7_7
Gencode Gene: ENSG00000159592.11_11
Transcript (Including UTRs)
Position: hg19 chr1:46,092,976-46,152,208 Size: 59,233 Total Exon Count: 12 Strand: -
Coding Region
Position: hg19 chr1:46,093,928-46,124,759 Size: 30,832 Coding Exon Count: 10

Page Index	Sequence and Links	UniProtKB Comments	Primers	CTD	Gene Alleles
RNA-Seq Expression	Microarray Expression	RNA Structure	Protein Structure	Other Species	GO Annotations
mRNA Descriptions	Other Names	Model Information	Methods

Data last updated at UCSC: 2024-08-22 23:36:26

Sequence and Links to Tools and Databases

Genomic Sequence (chr1:46,092,976-46,152,208)			mRNA (may differ from genome)		Protein (474 aa)
Gene Sorter	Genome Browser	Other Species FASTA	VisiGene	Gene interactions	Table Schema
AlphaFold	BioGPS	Ensembl	ExonPrimer	GeneCards	HGNC
MGI	PubMed	UniProtKB

Comments and Description Text from UniProtKB


	ID: GPBL1_HUMAN DESCRIPTION: RecName: Full=Vasculin-like protein 1; AltName: Full=GC-rich promoter-binding protein 1-like 1; FUNCTION: Possible transcription factor (Probable). SUBCELLULAR LOCATION: Nucleus (Probable). SIMILARITY: Belongs to the vasculin family.

Primer design for this transcript

Primer3Plus can design qPCR Primers that straddle exon-exon-junctions, which amplify only cDNA, not genomic DNA.
Click here to load the transcript sequence and exon structure into Primer3Plus

Exonprimer can design one pair of Sanger sequencing primers around every exon, located in non-genic sequence.
Click here to open Exonprimer with this transcript

To design primers for a non-coding sequence, zoom to a region of interest and select from the drop-down menu: View > In External Tools > Primer3

Comparative Toxicogenomics Database (CTD)


	The following chemicals interact with this gene D015123 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide D001564 Benzo(a)pyrene D002794 Choline D003993 Dibutyl Phthalate D005492 Folic Acid D006830 Hydralazine D008715 Methionine D008748 Methylcholanthrene D014635 Valproic Acid C018021 cobaltous chloride more ... click here to view the complete list

Common Gene Haplotype Alleles


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RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)


	Highest median expression: 26.46 RPKM in Testis Total median expression: 711.18 RPKM View in GTEx track of Genome Browser View at GTEx portal View GTEx Body Map

Microarray Expression Data


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mRNA Secondary Structure of 3' and 5' UTRs

Region	Fold Energy	Bases	Energy/Base	Display As
5' UTR	-322.30	1222	-0.264	Picture	PostScript	Text
3' UTR	-230.50	952	-0.242	Picture	PostScript	Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

Protein Domain and Structure Information

Pfam Domains:
PF15337 - Vascular protein family Vasculin-like 1

ModBase Predicted Comparative 3D Structure on Q9HC44


Front	Top	Side

The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

Orthologous Genes in Other Species

Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.

Mouse	Rat	Zebrafish	D. melanogaster	C. elegans	S. cerevisiae
No ortholog	No ortholog	No ortholog	No ortholog	No ortholog	No ortholog
Gene Details	Gene Details
Gene Sorter	Gene Sorter
	RGD	Ensembl

Gene Ontology (GO) Annotations with Structured Vocabulary


	Molecular Function: GO:0003677 DNA binding GO:0003700 transcription factor activity, sequence-specific DNA binding Biological Process: GO:0006351 transcription, DNA-templated GO:0006355 regulation of transcription, DNA-templated GO:0045893 positive regulation of transcription, DNA-templated Cellular Component: GO:0005634 nucleus

Descriptions from all associated GenBank mRNAs


	LF383896 - JP 2014500723-A/191399: Polycomb-Associated Non-Coding RNAs. BC068578 - Homo sapiens GC-rich promoter binding protein 1-like 1, mRNA (cDNA clone IMAGE:4829660). MA619473 - JP 2018138019-A/191399: Polycomb-Associated Non-Coding RNAs. BC052257 - Homo sapiens GC-rich promoter binding protein 1-like 1, mRNA (cDNA clone MGC:59658 IMAGE:6297561), complete cds. AL834194 - Homo sapiens mRNA; cDNA DKFZp434H1428 (from clone DKFZp434H1428). AF177334 - Homo sapiens clone SP192 unknown mRNA. JD410600 - Sequence 391624 from Patent EP1572962. BC022218 - Homo sapiens GC-rich promoter binding protein 1-like 1, mRNA (cDNA clone MGC:17847 IMAGE:3900818), complete cds. AK024972 - Homo sapiens cDNA: FLJ21319 fis, clone COL02312. AK027212 - Homo sapiens cDNA: FLJ23559 fis, clone LNG09844. LF356223 - JP 2014500723-A/163726: Polycomb-Associated Non-Coding RNAs. JD535246 - Sequence 516270 from Patent EP1572962. JD225528 - Sequence 206552 from Patent EP1572962. BC015713 - Homo sapiens GC-rich promoter binding protein 1-like 1, mRNA (cDNA clone MGC:16819 IMAGE:3909296), complete cds. JD550726 - Sequence 531750 from Patent EP1572962. JD244288 - Sequence 225312 from Patent EP1572962. JD037389 - Sequence 18413 from Patent EP1572962. JD374727 - Sequence 355751 from Patent EP1572962. AK225197 - Homo sapiens mRNA for GC-rich promoter binding protein 1-like 1 variant, clone: COL02312. DQ892484 - Synthetic construct clone IMAGE:100005114; FLH186732.01X; RZPDo839H0871D GC-rich promoter binding protein 1-like 1 (GPBP1L1) gene, encodes complete protein. KJ899396 - Synthetic construct Homo sapiens clone ccsbBroadEn_08790 GPBP1L1 gene, encodes complete protein. DQ895695 - Synthetic construct Homo sapiens clone IMAGE:100010155; FLH186728.01L; RZPDo839H0861D GC-rich promoter binding protein 1-like 1 (GPBP1L1) gene, encodes complete protein. KJ906285 - Synthetic construct Homo sapiens clone ccsbBroadEn_15955 GPBP1L1 gene, encodes complete protein. AB527870 - Synthetic construct DNA, clone: pF1KB0423, Homo sapiens GPBP1L1 gene for GC-rich promoter binding protein 1-like 1, without stop codon, in Flexi system. LF332737 - JP 2014500723-A/140240: Polycomb-Associated Non-Coding RNAs. CU692498 - Synthetic construct Homo sapiens gateway clone IMAGE:100017342 5' read GPBP1L1 mRNA. CU677401 - Synthetic construct Homo sapiens gateway clone IMAGE:100017340 5' read GPBP1L1 mRNA. BC022863 - Homo sapiens GC-rich promoter binding protein 1-like 1, mRNA (cDNA clone IMAGE:4077047), with apparent retained intron. JD111159 - Sequence 92183 from Patent EP1572962. JD236924 - Sequence 217948 from Patent EP1572962. MA591800 - JP 2018138019-A/163726: Polycomb-Associated Non-Coding RNAs. MA568314 - JP 2018138019-A/140240: Polycomb-Associated Non-Coding RNAs.

Other Names for This Gene


	Alternate Gene Symbols: AL834194, D3DQ10, ENST00000290795.1, ENST00000290795.2, ENST00000290795.3, ENST00000290795.4, ENST00000290795.5, ENST00000290795.6, GPBL1_HUMAN, Q9H751, Q9HC44, SP192, uc317kwe.1, uc317kwe.2 UCSC ID: ENST00000290795.7_7 RefSeq Accession: NM_021639.5 Protein: Q9HC44 (aka GPBL1_HUMAN)

Gene Model Information


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Methods, Credits, and Use Restrictions


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