Human Gene ADGRG7 (ENST00000273352.8_10) from GENCODE V47lift37
  Description: adhesion G protein-coupled receptor G7, transcript variant 1 (from RefSeq NM_032787.3)
Gencode Transcript: ENST00000273352.8_10
Gencode Gene: ENSG00000144820.8_12
Transcript (Including UTRs)
   Position: hg19 chr3:100,328,445-100,414,323 Size: 85,879 Total Exon Count: 16 Strand: +
Coding Region
   Position: hg19 chr3:100,328,701-100,413,845 Size: 85,145 Coding Exon Count: 16 

Page IndexSequence and LinksUniProtKB CommentsPrimersMalaCardsGene Alleles
RNA-Seq ExpressionRNA StructureProtein StructureOther SpeciesGO AnnotationsmRNA Descriptions
Other NamesModel InformationMethods
Data last updated at UCSC: 2024-08-22 23:36:26

-  Sequence and Links to Tools and Databases
 
Genomic Sequence (chr3:100,328,445-100,414,323)mRNA (may differ from genome)Protein (797 aa)
Gene SorterGenome BrowserOther Species FASTAVisiGeneTable SchemaAlphaFold
BioGPSEnsemblEntrez GeneExonPrimerGeneCardsMalacards
MGIOMIMPubMedUniProtKBWikipediaBioGrid CRISPR DB

-  Comments and Description Text from UniProtKB
  ID: GP128_HUMAN
DESCRIPTION: RecName: Full=Probable G-protein coupled receptor 128; Flags: Precursor;
FUNCTION: Orphan receptor.
SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein.
SIMILARITY: Belongs to the G-protein coupled receptor 2 family. LN-TM7 subfamily.
SIMILARITY: Contains 1 GPS domain.
SEQUENCE CAUTION: Sequence=AAO27358.1; Type=Erroneous initiation;

-  Primer design for this transcript
 

Primer3Plus can design qPCR Primers that straddle exon-exon-junctions, which amplify only cDNA, not genomic DNA.
Click here to load the transcript sequence and exon structure into Primer3Plus

Exonprimer can design one pair of Sanger sequencing primers around every exon, located in non-genic sequence.
Click here to open Exonprimer with this transcript

To design primers for a non-coding sequence, zoom to a region of interest and select from the drop-down menu: View > In External Tools > Primer3


-  MalaCards Disease Associations
  MalaCards Gene Search: ADGRG7
Diseases sorted by gene-association score: fibrogenesis imperfecta ossium (4)

+  Common Gene Haplotype Alleles
  Press "+" in the title bar above to open this section.

-  RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
  Highest median expression: 10.59 RPKM in Small Intestine - Terminal Ileum
Total median expression: 14.52 RPKM



View in GTEx track of Genome Browser    View at GTEx portal     View GTEx Body Map

-  mRNA Secondary Structure of 3' and 5' UTRs
 
RegionFold EnergyBasesEnergy/Base
Display As
5' UTR -62.40256-0.244 Picture PostScript Text
3' UTR -83.90478-0.176 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Protein Domain and Structure Information
  InterPro Domains: Graphical view of domain structure
IPR017981 - GPCR_2-like
IPR000832 - GPCR_2_secretin-like
IPR000203 - GPS_dom

Pfam Domains:
PF00002 - 7 transmembrane receptor (Secretin family)
PF01825 - GPCR proteolysis site, GPS, motif

SCOP Domains:
49899 - Concanavalin A-like lectins/glucanases
81321 - Family A G protein-coupled receptor-like
57196 - EGF/Laminin

ModBase Predicted Comparative 3D Structure on Q96K78
FrontTopSide
The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
MouseRatZebrafishD. melanogasterC. elegansS. cerevisiae
No orthologNo orthologNo orthologNo orthologNo orthologNo ortholog
Gene DetailsGene Details    
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-  Gene Ontology (GO) Annotations with Structured Vocabulary
  Molecular Function:
GO:0004871 signal transducer activity
GO:0004888 transmembrane signaling receptor activity
GO:0004930 G-protein coupled receptor activity
GO:0005515 protein binding

Biological Process:
GO:0007165 signal transduction
GO:0007166 cell surface receptor signaling pathway
GO:0007186 G-protein coupled receptor signaling pathway

Cellular Component:
GO:0016020 membrane
GO:0016021 integral component of membrane


-  Descriptions from all associated GenBank mRNAs
  AK027360 - Homo sapiens cDNA FLJ14454 fis, clone HEMBB1001872, weakly similar to CELL SURFACE GLYCOPROTEIN EMR1 PRECURSOR.
BC113451 - Homo sapiens G protein-coupled receptor 128, mRNA (cDNA clone MGC:142011 IMAGE:8322503), complete cds.
BC130388 - Homo sapiens G protein-coupled receptor 128, mRNA (cDNA clone MGC:163260 IMAGE:40146419), complete cds.
KJ895043 - Synthetic construct Homo sapiens clone ccsbBroadEn_04437 GPR128 gene, encodes complete protein.
KJ899839 - Synthetic construct Homo sapiens clone ccsbBroadEn_09233 GPR128 gene, encodes complete protein.
HQ258644 - Synthetic construct Homo sapiens clone IMAGE:100072674 G protein-coupled receptor 128 (GPR128) gene, encodes complete protein.
AY181246 - Homo sapiens G protein-coupled receptor 128 (GPR128) mRNA, partial cds.
AK295345 - Homo sapiens cDNA FLJ55998 complete cds, highly similar to Probable G-protein coupled receptor 128 precursor.
AK172769 - Homo sapiens cDNA FLJ23930 fis, clone COL06318.
AK131069 - Homo sapiens cDNA FLJ29035 fis, clone LNF07987.
AK172774 - Homo sapiens cDNA FLJ23935 fis, clone COLF0858.
AK122804 - Homo sapiens cDNA FLJ16382 fis, clone TLIVE2006621, weakly similar to H.sapiens mRNA for HE6 Tm7 receptor.
JD263846 - Sequence 244870 from Patent EP1572962.
JD146561 - Sequence 127585 from Patent EP1572962.
JD245221 - Sequence 226245 from Patent EP1572962.
JD289851 - Sequence 270875 from Patent EP1572962.
JD213719 - Sequence 194743 from Patent EP1572962.
JD495236 - Sequence 476260 from Patent EP1572962.
JD430645 - Sequence 411669 from Patent EP1572962.
JD530705 - Sequence 511729 from Patent EP1572962.
JD166382 - Sequence 147406 from Patent EP1572962.
JD381979 - Sequence 363003 from Patent EP1572962.
JD528991 - Sequence 510015 from Patent EP1572962.

-  Other Names for This Gene
  Alternate Gene Symbols: AGRG7_HUMAN, ENST00000273352.1, ENST00000273352.2, ENST00000273352.3, ENST00000273352.4, ENST00000273352.5, ENST00000273352.6, ENST00000273352.7, GPR128, NM_032787, Q14D94, Q86SQ2, Q96K78, uc317jbr.1, uc317jbr.2
UCSC ID: ENST00000273352.8_10
RefSeq Accession: NM_032787.3
Protein: Q96K78 (aka GP128_HUMAN or G128_HUMAN)

-  Gene Model Information
  Click here for a detailed description of the fields of the table above.

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.